Electrodeposited dopamine/strontium-doped hydroxyapatite composite coating on pure zinc for anti-corrosion, antimicrobial and osteogenesis

Wang, Bingbing; Li, Yichao; Wang, Saisai; Jia, Fenghuan; Bian, Anqi; Wang, Kun; Xie, Lei; Yan, Ke; Qiao, Hongchao; Lin, He; Lan, Jinping; Huang, Yong

doi:10.1016/j.msec.2021.112387

Cited by 65 publications

(26 citation statements)

References 54 publications

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“…This was probably because the loaded ZnO NPs released proper Zn 2+ continuously, which had been revealed to benefit cell proliferation. 18,34,35 In addition, ZnO NPs loaded on nZnO/MTC-Ti might collaborate with the MTC structure to boost cell growth. The enhanced cell adhesion activity of nZnO/MTC-Ti also assisted in the intercellular exchange of signals and molecules, which promoted cell proliferation.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Osteogenic differentiation of BMSCs plays a significant role in bone regeneration and implant osseointegration. , It has been revealed that appropriate zinc ion microenvironment can benefit osteogenic differentiation; , however, it is necessary to understand the synergetic effects of the MTC structure and ZnO NPs. On day 7 and day 14, the RT-PCR analysis revealed that mRNA expression of the main osteoblast markers (Runx2, ALP, OPN, and OCN) was highest on nZnO/MTC-Ti (Figure A).…”

Section: Resultsmentioning

confidence: 99%

“…Antibacterial activity is one of the fundamental elements in determining long-term stable osseointegration. 34 The ex vivo maxillary segments and implants extracted from SD rats were cultured under aerobic and anaerobic conditions. The results showed that nZnO/MTC-Ti and nZnO-Ti had the most transparent culture solution and smallest OD value, indicating their superior inhibitory activity against aerobic and anaerobic bacteria (Figure 8A,B).…”

Section: Zinc Microenvironment Homeostasis and Znmentioning

confidence: 99%

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Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Wen¹,

Shi

Li³

et al. 2023

ACS Appl. Mater. Interfaces

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Two major issues are currently hindering the clinical practice of titanium dental implants for the lack of biological activities: immediate/early loading risks and peri-implantitis. To solve these issues, it is urgent to develop multifunctional implants modified with effective osteogenic and antibacterial properties. Zinc oxide nanoparticles (ZnO NPs) possess superior antibacterial activity; however, they can rapidly release Zn2+, causing cytotoxicity. In this study, a potential dental implant modification was creatively developed as ZnO nanoparticle-loaded mesoporous TiO2 coatings (nZnO/MTC-Ti) via the evaporation-induced self-assembly method (EISA) and one-step spin coating. The mesoporous TiO2 coatings (MTCs) regulated the synthesis and loading of ZnO NPs inside the nanosized pores. The synergistic effects of MTC and ZnO NPs on nZnO/MTC-Ti not only controlled the long-term steady-state release of Zn2+ but also optimized the charge distribution on the surface. Therefore, the cytotoxicity of ZnO NPs was resolved without triggering excessive reactive oxygen species (ROS). The increased extracellular Zn2+ further promoted a favorable intracellular zinc ion microenvironment through the modulation of zinc transporters (ZIP1 and ZnT1). Owing to that, the adhesion, proliferation, and osteogenic activity of bone mesenchymal stem cells (BMSCs) were improved. Additionally, nZnO/MTC-Ti inhibited the proliferation of oral pathogens (Pg and Aa) by inducing bacterial ROS production. For in vivo experiments, different implants were implanted into the alveolar fossa of Sprague–Dawley rats immediately after tooth extraction. The nZnO/MTC-Ti implants were found to possess a higher capability for enhancing bone regeneration, antibiosis, and osseointegration in vivo. These findings suggested the outstanding performance of nZnO/MTC-Ti implants in accelerating osseointegration and inhibiting bacterial infection, indicating a huge potential for solving immediate/early loading risks and peri-implantitis of dental implants.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Zinc Microenvironment Homeostasis and Znmentioning

confidence: 99%

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Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Wen¹,

Shi

Li³

et al. 2023

ACS Appl. Mater. Interfaces

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“…It is also crucial for vascular development ( Zhao et al, 2018 ). When combined with HA, the osteogenic activity will be synergistically enhanced ( Wei et al, 2017 ; Wang S. et al, 2019 ; Wang B. et al, 2021 ; Sun Y. et al, 2021 ). Sun et al ( Sun Y. et al, 2021 ) firstly fabricated PDA coating as intermediate layer on Ti substrate and further constructed a Sr-substituted apatite coating, which was able to regulate PI3K/AKT and FAK/MAPK signaling pathways, and in turn promote osteogenesis and angiogenesis.…”

Section: Pda-mediated Components For Multilayered Coatings On Biomate...mentioning

confidence: 99%

Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Zhao

Lin

et al. 2022

Front. Bioeng. Biotechnol.

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Repairing bone defects remains a challenge in clinical practice and the application of artificial scaffolds can enhance local bone formation, but the function of unmodified scaffolds is limited. Considering different application scenarios, the scaffolds should be multifunctionalized to meet specific demands. Inspired by the superior adhesive property of mussels, polydopamine (PDA) has attracted extensive attention due to its universal capacity to assemble on all biomaterials and promote further adsorption of multiple external components to form PDA-based multilayered coatings with multifunctional property, which can induce synergistic enhancement of new bone formation, such as immunomodulation, angiogenesis, antibiosis and antitumor property. This review will summarize mussel-inspired PDA-based multilayered coatings for enhanced bone formation, including formation mechanism and biofunction of PDA coating, as well as different functional components. The synergistic enhancement of multiple functions for better bone formation will also be discussed. This review will inspire the design and fabrication of PDA-based multilayered coatings for different application scenarios and promote deeper understanding of their effect on bone formation, but more efforts should be made to achieve clinical translation. On this basis, we present a critical conclusion, and forecast the prospects of PDA-based multilayered coatings for bone regeneration.

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“…The most used strategy to combat bacterial infections is using antibiotics or transition metal ions (such as silver, copper, and zinc) [ 7 ]. However, it may cause drug resistance [ 8 ] and cytotoxicity [ 9 , 10 ], and implants may still undergo bacterial infection after the antibiotics is completely released. Therefore, this strategy cannot work for a long time [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities

Hao

Zhou

Xie

et al. 2022

Materials Today Bio

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Electrodeposited dopamine/strontium-doped hydroxyapatite composite coating on pure zinc for anti-corrosion, antimicrobial and osteogenesis

Cited by 65 publications

References 54 publications

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities

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Electrodeposited dopamine/strontium-doped hydroxyapatite composite coating on pure zinc for anti-corrosion, antimicrobial and osteogenesis

Cited by 65 publications

References 54 publications

Mesoporous TiO2 Coatings Regulate ZnO Nanoparticle Loading and Zn2+ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mesoporous TiO2 Coatings Regulate ZnO Nanoparticle Loading and Zn2+ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Porous thermosensitive coating with water-locking ability for enhanced osteogenic and antibacterial abilities

Contact Info

Product

Resources

About

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity

Mesoporous TiO₂ Coatings Regulate ZnO Nanoparticle Loading and Zn²⁺ Release on Titanium Dental Implants for Sustained Osteogenic and Antibacterial Activity