Mussel-Inspired Polydopamine-Based Multilayered Coatings for Enhanced Bone Formation

Abstract

Repairing bone defects remains a challenge in clinical practice and the application of artificial scaffolds can enhance local bone formation, but the function of unmodified scaffolds is limited. Considering different application scenarios, the scaffolds should be multifunctionalized to meet specific demands. Inspired by the superior adhesive property of mussels, polydopamine (PDA) has attracted extensive attention due to its universal capacity to assemble on all biomaterials and promote further adsorption of multiple external components to form PDA-based multilayered coatings with multifunctional property, which can induce synergistic enhancement of new bone formation, such as immunomodulation, angiogenesis, antibiosis and antitumor property. This review will summarize mussel-inspired PDA-based multilayered coatings for enhanced bone formation, including formation mechanism and biofunction of PDA coating, as well as different functional components. The synergistic enhancement of multiple functions for better bone formation will also be discussed. This review will inspire the design and fabrication of PDA-based multilayered coatings for different application scenarios and promote deeper understanding of their effect on bone formation, but more efforts should be made to achieve clinical translation. On this basis, we present a critical conclusion, and forecast the prospects of PDA-based multilayered coatings for bone regeneration.

Nano-Hydroxyapatite Composite Scaffolds Loaded with Bioactive Factors and Drugs for Bone Tissue Engineering

“…Recently, mussel-inspired polydopamine (PDA) coating has attracted wide attention for its unique adhesion [ 187 ]. PDA can be tightly bound to different surfaces by covalent and noncovalent interactions, so it can be used as an intermediate to immobilize biomolecules onto various natural or synthetic scaffold surfaces [ 188 , 189 ]. Zhou et al successfully bonded BMP-2-derived peptide (P24 peptide) to n-HAp/RHLC/PLA scaffold by PDA-assisted coating.…”

Biomimetic approaches and materials in restorative and regenerative dentistry: review article

“…Polydopamine (PDA) is a semi conductive polymer that is formed by the oxidation and polymerization of dopamine in aqueous solutions [58]. It is called biological glue due to its strong ability to bond to several substrates under wet conditions [59].…”

A Ti3C2 MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

“…Polydopamine (PDA) has been used extensively in the biomedical field given its outstanding biocompatibility, high hydrophilicity, and diverse modification potential. 33,34 In addition, PDA also exhibits high PCE and ROS scavenging capacities. 35,36 Therefore, it is a feasible approach to load MXenes onto 3D porous scaffolds with the help of PDA to simultaneously realize anti-infection, ROS scavenging, and osteogenesis at the defect sites.…”