Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network

Camilleri, Julia A.; Hoffstaedter, Felix; Zavorotny, Maxim; Zöllner, Rebecca; Thomann, Philipp A.; Redlich, Ronny; Dannlowski, Udo; Grözinger, Michael; Demirakça, Traute; Sartorius, Alexander; Eickhoff, Simon B.; Nickl‐Jockschat, Thomas

doi:10.1016/j.nicl.2019.102114

Cited by 19 publications

(10 citation statements)

References 87 publications

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“…Intriguingly, electroconvulsive therapy (ECT) has been identified as a potential intervention to increase hippocampal volume, global functioning, and quality of life in patients [86][87][88]. We believe these results emphasize the validity of hippocampal GMV as a transdiagnostic correlate of psychopathology that could be a target for intervention and prevention.…”

Section: Diagnoses-common Gmv Alterationsmentioning

confidence: 84%

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

et al. 2022

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Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk factors, genetics, and other biological measures. Based on previous findings, it remains unclear what transdiagnostic regional gray matter volume (GMV) alterations exist across these disorders, and with which factors they are associated. GMV (3-T magnetic resonance imaging) was compared between healthy controls (HC; n = 110), DSM-IV-TR diagnosed MDD (n = 110), BD (n = 110), and SSD patients (n = 110), matched for age and sex. We applied a conjunction analysis to identify shared GMV alterations across the disorders. To identify potential origins of identified GMV clusters, we associated them with early and current risk and protective factors, psychopathology, and neuropsychology, applying multiple regression models. Common to all diagnoses (vs. HC), we identified GMV reductions in the left hippocampus. This cluster was associated with the neuropsychology factor working memory/executive functioning, stressful life events, and with global assessment of functioning. Differential effects between groups were present in the left and right frontal operculae and left insula, with volume variances across groups highly overlapping. Our study is the first with a large, matched, transdiagnostic sample to yield shared GMV alterations in the left hippocampus across major mental disorders. The hippocampus is a major network hub, orchestrating a range of mental functions. Our findings underscore the need for a novel stratification of mental disorders, other than categorical diagnoses.

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Section: Diagnoses-common Gmv Alterationsmentioning

confidence: 84%

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

et al. 2022

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“…due to cells) and thereby a degeneration of microstructural integrity; several investigations showed a decrease in mean diffusivity after a course of ECT favoring neuroplasticity as underlying mechanism over vasogenic edema that would be accompanied by an increased mean diffusivity due to accumulating extracellular fluids [18,50,74]. Still, an intracellular fluid/ion shift (cell swelling) induced by the seizure cannot be ruled out and would explain the reversibility of the volumetric effects [75]. Finally, response to ECT has been associated with polymorphisms of the BDNF gene [76,77], while the vascular endothelial growth factor (VEGF) gene was linked to hippocampal growth [78].…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of brain structural changes after electroconvulsive therapy in depression

et al. 2021

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Background: Increases in the volume of the amygdala and hippocampus after electroconvulsive therapy (ECT) are among the most robust effects known to the brain-imaging field. Recent advances in the segmentation of substructures of these regions allow for novel insights on the relationship between brain structure and clinical outcomes of ECT. Objective: We aimed to provide a comprehensive synthesis of evidence available on changes in brain structure after ECT, including recently published data on hippocampal subfields. Methods: A meta-analysis of published studies was carried out using random-effects models of standardized mean change of regional brain volumes measured with longitudinal magnetic resonance imaging of depressive patients before and after a series of ECT. Results: Data from 21 studies (543 depressed patients) were analysed, including 6 studies (118 patients) on hippocampal subfields. Meta-analyses could be carried out for seven brain regions for which data from at least three published studies was available. We observed increases in left and right hippocampi, amygdalae, cornua ammonis (CA) 1, CA 2/3, dentate gyri (DG) and subicula with standardized mean change scores ranging between 0.34 and 1.15. The model did not reveal significant volume increases in the caudate. Meta-regression indicated a negative relationship between the reported increases in the DG and relative symptom improvement (À0.27 (SE: 0.09) per 10%). Conclusions: ECT is accompanied by significant volume increases in the bilateral hippocampus and amygdala that are not associated with treatment outcome. Among hippocampal subfields, the most robust volume increases after ECT were measured in the dentate gyrus. The indicated negative correlation of this effect with antidepressant efficacy warrants replication in data of individual patients.

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“…Electroconvulsive therapy (ECT), a highly effective treatment for refractory depression, is thought to be excellent for neuroplasticity (Cai et al, 2022 ). Several studies have found that electroconvulsive therapy causes a significant increase in GMV in the right amygdala (Gryglewski et al, 2019 , 2021 ; Camilleri et al, 2020 ). Our previous study confirmed that ECT can selectively increase the volume of the hippocampal-amygdala transition region bilaterally in patients with depression (Xu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Structural and functional improvement of amygdala sub-regions in postpartum depression after acupuncture

Huang

Zhuo

Wang

et al. 2023

Front. Hum. Neurosci.

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ObjectiveThis study aimed to analyze the changes in structure and function in amygdala sub-regions in patients with postpartum depression (PPD) before and after acupuncture.MethodsA total of 52 patients with PPD (All-PPD group) were included in this trial, 22 of which completed 8 weeks of acupuncture treatment (Acu-PPD group). An age-matched control group of 24 healthy postpartum women (HPW) from the hospital and community were also included. Results from the 17-Hamilton Depression Scale (17-HAMD) and the Edinburgh Postnatal Depression Scale (EPDS) were evaluated, and resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed at baseline and after the acupuncture treatment. Sub-regions of the amygdala were used as seed regions to measure gray matter volume (GMV) and analyzed for resting-state functional connectivity (RSFC) values separately. Finally, correlation analyses were performed on all patients with PPD to evaluate association values between the clinical scale scores, GMV, and RSFC values, while controlling for age and education. Pearson's correlation analyses were conducted to investigate the relevance between GMV and RSFC values of brain regions that differed before and after acupuncture treatment and clinical scale scores in Acu-PPD patients.ResultsThe HAMD scores for Acu-PPD were reduced after acupuncture treatment (P < 0.05), suggesting the positive effects of acupuncture on depression symptoms. Structurally, the All-PPD group showed significantly decreased GMV in the left lateral part of the amygdala (lAMG.L) and the right lateral part of the amygdala (lAMG.R) compared to the HPW group (P < 0.05). In addition, the GMV of lAMG.R was marginally increased in the Acu-PPD group after acupuncture (P < 0.05). Functionally, the Acu-PPD group showed a significantly enhanced RSFC between the left medial part of the amygdala (mAMG.L) and the left vermis_6, an increased RSFC between the right medial part of the amygdala (mAMG.R) and left vermis_6, and an increased RSFC between the lAMG.R and left cerebelum_crus1 (P < 0.05). Moreover, correlation studies revealed that the GMV in the lAMG.R was significantly related to the EPDS scores in the All-PPD group (P < 0.05).ConclusionOur findings demonstrated that the structure of amygdala sub-regions is impaired in patients with PPD. Acupuncture may improve depressive symptoms in patients with PPD, and the mechanism may be attributed to changes in the amygdala sub-region structure and the functional connections of brain areas linked to the processing of negative emotions. The fMRI-based technique can provide comprehensive neuroimaging evidence to visualize the central mechanism of action of acupuncture in PPD.

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Electroconvulsive therapy modulates grey matter increase in a hub of an affect processing network

Cited by 19 publications

References 87 publications

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

Meta-analysis of brain structural changes after electroconvulsive therapy in depression

Structural and functional improvement of amygdala sub-regions in postpartum depression after acupuncture

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