Electroconvulsive therapy changes the regional resting state function measured by regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in elderly major depressive disorder patients: An exploratory study

Kong, Xiaoming; Xu, Shu-xian; Sun, Yan; Wang, Ke-Yong; Wang, Chen; Zhang, J.; Xia, Jin-xiang; Zhang, Li; Tan, Bo-jian; Xie, Xin

doi:10.1016/j.pscychresns.2017.04.001

Cited by 39 publications

(27 citation statements)

References 74 publications

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“…At the neural level, we observed that variance in depressive symptoms could be explained by the fALFF in the left SFG, which fits well with the findings of numerous RS‐fMRI studies that have revealed associations between depressive symptoms and local spontaneous activity and connectivity in the SFG (Iwabuchi et al, ; Kaiser, Andrews‐Hanna, Wager, & Pizzagalli, ; Sundermann, Beverborg, & Pfleiderer, ). Evidence from a recent RS‐fMRI research further demonstrated that electroconvulsive therapy changed the local spontaneous activity and connectivity in the SFG, which, in turn, reduced depressive symptoms in elderly major depressive disorder patients (Kong et al, ). Moreover, the structure of the SFG has been repeatedly reported to be associated with depressive symptoms among different populations (Peng, Chen, Yin, Jia, & Gong, ; Zhao et al, ).…”

Section: Discussionmentioning

confidence: 99%

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Wang

Zhao

Zhang

et al. 2019

Human Brain Mapping

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Identifying factors for the prediction of depression is a long‐standing research topic in psychiatry and psychology. Perceived stress, which reflects the tendency to appraise one's life situations as stressful and overwhelming, has emerged as a stable predictor for depressive symptoms. However, the neurobiological bases of perceived stress and how perceived stress influences depressive symptoms in the healthy brain remain largely unknown. Here, we investigated these issues in 217 healthy adolescents by estimating the fractional amplitude of low‐frequency fluctuations (fALFFs) via resting‐state functional magnetic resonance imaging. A whole‐brain correlation analysis showed that higher levels of perceived stress were associated with greater fALFF in the left superior frontal gyrus (SFG), which is a core brain region for cognitive control and emotion regulation‐related processes. Mediation analysis further indicated that perceived stress mediated the link between the fALFF in the left SFG and depressive symptoms. Importantly, our results remained significant even when excluding the influences of head motion, anxiety, SFG gray matter structure, and school environment. Altogether, our findings suggested that the fALFF in the left SFG is a neurofunctional marker of perceived stress in adolescents and revealed a potential indirect effect of perceived stress on the association between the SFG spontaneous activity and depressive symptoms.

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Section: Discussionmentioning

confidence: 99%

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Wang

Zhao

Zhang

et al. 2019

Human Brain Mapping

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“…Notably, studies have shown that suicidal ideation is relevant to the changing resting-state brain activities in major depressive disorder (19). Electroconvulsive therapy, as a quick and effective treatment for severe depression, can relieve symptoms of depression, as well as alter resting-state brain activities (20). Therefore, application of ALFF in depression can play a role in diagnosing depression, judging the period of depression, and even providing a new perspective for selection of therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Altered Patterns of the Fractional Amplitude of Low-Frequency Fluctuation in Drug-Naive First-Episode Unipolar and Bipolar Depression

et al. 2020

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Background: An early and correct diagnosis is crucial for treatment of unipolar depression (UD) and bipolar disorder (BD). The fractional amplitude of low-frequency fluctuations (fALFFs) has been widely used in the study of neuropsychiatric diseases, as it can detect spontaneous brain activities. This study was conducted to survey changes of fALFF within various frequency bands of the UD and BD patients, as well as to explore the effects on changes in fALFF on cognitive function. Methods: In total, 58 drug-naive first-episode patients, including 32 UD and 26 BD, were enrolled in the study. The fALFF values were calculated under slow-5 band (0.01–0.027 Hz) and slow-4 band (0.027–0.073 Hz) among UD patients, BD patients, and healthy control (HC). Additionally, we conducted correlation analyses to examine the association between altered fALFF values and cognitive function. Results: Under the slow-5 band, compared to the HC group, the UD group showed increased fALFF values in the right cerebellum posterior lobe, whereas the BD group showed increased fALFF values in the left middle temporal gyrus (MTG). Under the slow-4 band, in comparison to HC, the UD group showed increased fALFF values in the left superior temporal gyrus, whereas the right inferior parietal lobule (IPL) and BD group showed increased fALFF values in the bilateral postcentral gyrus. Notably, compared to BD, the UD group showed increased fALFF values in the right IPL under the slow-4 band. Furthermore, altered fALFF values in the left MTG and the right IPL were significantly positively correlated with Verbal Fluency Test scores. Conclusions: This current study indicated that there were changes in brain activities in the early UD and BD groups, and changes were related to executive function. The fALFF values can serve as potential biomarker to diagnose and differentiate UD and BD patients.

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“…High ReHo values indicate that high synchronous oscillations of neurons in ALFF are directly related to the intensity of spontaneous neural activity in energy metabolism at resting state [ 23 ]. Kong et al compared the differences in ReHo and low-frequency amplitude (ALFF) in brain regions before and after treatment with electroconvulsive therapy (ECT) in elderly patients with major depressive disorder (MDD); results show that ECT may affect brain function in elderly patients with MDD at resting state [ 24 ]. Yao et al compared the ReHo of bipolar depression (BD), unipolar depression (UD), and healthy controls (HC) in the whole brain.…”

Section: Introductionmentioning

confidence: 99%

Neural Basis of Depression Related to a Dominant Right Hemisphere: A Resting-State fMRI Study

2018

Behavioural Neurology

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Background In the past, studies on the lateralization of the left and right hemispheres of the brain suggested that depression is dominated by the right hemisphere of the brain, but the neural basis of this theory remains unclear. Method Functional magnetic resonance imaging of the brain was performed in 22 depressive patients and 15 healthy controls. The differences in the mean values of the regional homogeneity (ReHo) of two groups were compared, and the low-frequency amplitudes of these differential brain regions were compared. Results The results show that compared with healthy subjects, depressive patients had increased ReHo values in the right superior temporal gyrus, right middle temporal gyrus, left inferior temporal gyrus, left middle temporal gyrus, right middle frontal gyrus, triangular part of the right inferior frontal gyrus, orbital part of the right inferior frontal gyrus, right superior occipital gyrus, right middle occipital gyrus, bilateral anterior cingulate, and paracingulate gyri; reduced ReHo values were seen in the right fusiform gyrus, left middle occipital gyrus, left lingual gyrus, and left inferior parietal except in the supramarginal and angular gyri. Conclusions The results show that regional homogeneity mainly occurs in the right brain, and the overall performance of the brain is such that right hemisphere synchronization is enhanced while left hemisphere synchronization is weakened. ReHo abnormalities in the resting state can predict abnormalities in individual neurological activities that reflect changes in the structure and function of the brain; abnormalities shown with this indicator are the neuronal basis for the phenomenon that the right hemisphere of the brain has a dominant effect on depression.

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Electroconvulsive therapy changes the regional resting state function measured by regional homogeneity (ReHo) and amplitude of low frequency fluctuations (ALFF) in elderly major depressive disorder patients: An exploratory study

Cited by 39 publications

References 74 publications

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Stress and the brain: Perceived stress mediates the impact of the superior frontal gyrus spontaneous activity on depressive symptoms in late adolescence

Altered Patterns of the Fractional Amplitude of Low-Frequency Fluctuation in Drug-Naive First-Episode Unipolar and Bipolar Depression

Neural Basis of Depression Related to a Dominant Right Hemisphere: A Resting-State fMRI Study

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