Altered Patterns of the Fractional Amplitude of Low-Frequency Fluctuation in Drug-Naive First-Episode Unipolar and Bipolar Depression

Chai, Xue; Zhang, Rongrong; Xue, Chen; Li, Zonghong; Huang, Qingling; Xiao, Chaoyong; Xie, Shusen

doi:10.3389/fpsyt.2020.587803

Cited by 17 publications

(9 citation statements)

References 45 publications

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“…Temporal cortex is located around the hippocampal-entorhinal complex and involves in the processing of emotions and cognitions. Structural and functional abnormalities of MTG in BD have been supported by other studies ( 55 , 56 ). A recent study also found that BD showed a relationship between weight gain and MTG volume loss ( 57 ).…”

Section: Discussionsupporting

confidence: 72%

Shared and distinct functional connectivity of hippocampal subregions in schizophrenia, bipolar disorder, and major depressive disorder

et al. 2022

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Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) share etiological and pathophysiological characteristics. Although neuroimaging studies have reported hippocampal alterations in SZ, BD, and MDD, little is known about how different hippocampal subregions are affected in these conditions because such subregions, namely, the cornu ammonis (CA), dentate gyrus (DG), and subiculum (SUB), have different structural foundations and perform different functions. Here, we hypothesize that different hippocampal subregions may reflect some intrinsic features among the major psychiatric disorders, such as SZ, BD, and MDD. By investigating resting functional connectivity (FC) of each hippocampal subregion among 117 SZ, 103 BD, 96 MDD, and 159 healthy controls, we found similarly and distinctly changed FC of hippocampal subregions in the three disorders. The abnormal functions of middle frontal gyrus might be the core feature of the psychopathological mechanisms of SZ, BD, and MDD. Anterior cingulate cortex and inferior orbital frontal gyrus might be the shared abnormalities of SZ and BD, and inferior orbital frontal gyrus is also positively correlated with depression and anxiety symptoms in SZ and BD. Caudate might be the unique feature of SZ and showed a positive correlation with the cognitive function in SZ. Middle temporal gyrus and supplemental motor area are the differentiating features of BD. Our study provides evidence for the different functions of different hippocampal subregions in psychiatric pathology.

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Section: Discussionsupporting

confidence: 72%

Shared and distinct functional connectivity of hippocampal subregions in schizophrenia, bipolar disorder, and major depressive disorder

et al. 2022

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“…In line with what was said about biomarkers of glutamatebased therapeutics, brain neuroimaging values of the fractional amplitude of the low-frequency fluctuation, widely used in the study of neuropsychiatric disorders, may also be potential biomarkers to diagnose and differentiate patients with MDD or bipolar depression [47]. The best value as a neuroimaging diagnostic marker of the first episode of MDD has been the combination of: a) an increased fractional amplitude of the low-frequency fluctuation in the right precuneus -which forms part of the superior parietal lobeand b) the increase of this amplitude in the left superior frontal gyrus [48,49].…”

Section: Glutamate Receptors and Biomarkersmentioning

confidence: 80%

Psychiatric Psychobiological Treatment Versus Exclusive Psychological Treatment in Depressive Disorders

Bertolín-Guillén¹

2023

AJPN

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Introduction: Scientific information on the antidepressant effectiveness of the varied usual therapeutic interventions is considerable but of poor quality. Objective: To analyse the scientifically well qualified international contributions on the effectiveness of habitual psychobiological psychiatric interventions in depressive disorders. Method: N= 6 structured bibliographic systems have been reviewed in a non-systematic, narrative and synthetic way and N= 75 significant contributions have been selected. Results and discussion: Patients with severe depression are more likely to receive any type of medical attention, but less likely to receive adequate attention. The use of both drugs and psychotherapy is the habitual mixed combined intervention during any ordinary psychiatric treatment. We will call it psychobiological or psychopharmacological intervention. The exclusive psychological intervention without using any medically prescribed drugs, is likely to be less cost/effective. The matter is not only to prioritise but also to adequately combine psychiatric interventions and added psychological interventions when convenient. The intervention on the neurophysiological pathways related with glutamate, the GABAergic, opioidergic, and inflammatory systems as well as on connectome and microbiome are being promoted for future drug antidepressant therapy with encouraging results. Conclusion: The mixed psychiatric option using drugs and psychotherapy, either regulated or not, by the intervening psychiatrist himself or herself is probably the main therapeutic choice for the correctly diagnosed depressive disorders. The psychotherapeutics intervention excluding the psychobiological psychiatric intervention in correctly diagnosed depressions will be insufficient in general. The professional psychological intervention may obviously complement the mixed psychiatric intervention, but can not replace it.

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“…The average kurtosis of gray matter in the IPL could help distinguish bipolar disorder from UD with high accuracy [ 61 , 62 ]. More recently fMRI study found that UD showed increased fALFF values in the IPL compared to bipolar disorder [ 63 ]. Our study provides new evidence to support this conclusion.…”

Section: Discussionmentioning

confidence: 99%

Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study

Chen

Feng

et al. 2021

BMC Psychiatry

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Background Depressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipolar disorder. Method According to diagnostic criteria of bipolar II disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and assessments, 13 bipolar II depression (BP II), 8 unipolar depression (UD) patients and 15 healthy controls (HC) were recruited in the study. We used 2-back tasks and magnetic source imaging (MSI) to test working memory functions and get the brain reactions of the participants. Results Compared with HC, only spatial working memory tasks accuracy was significantly worse in both UD and BP II (p = 0.001). Pearson correlation showed that the stronger the FCs’ strength of MFG-IPL and IPL-preSMA, the higher accuracy of SWM task within left FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, p = 0.031). However, the FC strength of IFG-IPL was negatively correlated with the accuracy of SWM task within left FPN in patients with BP II (r = − 0.591, p = 0.033). Conclusions Our study showed that the spatial working memory of patients with whether UD or BP II was impaired. The patterns of FCs within these two groups of patients were different when performing working memory tasks.

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Altered Patterns of the Fractional Amplitude of Low-Frequency Fluctuation in Drug-Naive First-Episode Unipolar and Bipolar Depression

Cited by 17 publications

References 45 publications

Shared and distinct functional connectivity of hippocampal subregions in schizophrenia, bipolar disorder, and major depressive disorder

Shared and distinct functional connectivity of hippocampal subregions in schizophrenia, bipolar disorder, and major depressive disorder

Psychiatric Psychobiological Treatment Versus Exclusive Psychological Treatment in Depressive Disorders

Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study

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