Electrocochleography

Eggermont, Jos J.

doi:10.1007/978-3-642-66082-5_15

Cited by 65 publications

(28 citation statements)

References 58 publications

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“…ECochG responses result from the superimposition of three components, two originating from receptor elements, the cochlear microphonic (CM) and the summating potential (SP), and the third, the compound action potential (CAP), arising from the synchronous activation of auditory nerve fibers innervating the basal portion of the cochlea (Eggermont, 1976). CM responses are believed to originate mainly from the sum of the extracellular components of receptor potentials arising from OHCs located in the basal cochlear region (Dallos and Cheatham, 1976).…”

Section: Cochlear Potentialsmentioning

confidence: 99%

“…Receptor and neural activities are intermingled in ECochG waveforms, often preventing the identification of individual components. Since CM activity is strictly related to basilar membrane motion, the procedure of averaging the potentials evoked separately by condensation and rarefaction stimuli is generally used to extract both the SP and the CAP components (Eggermont, 1976). Fig.…”

Section: Cochlear Potentialsmentioning

confidence: 99%

“…The CM potential appears as an oscillatory activity identified as low as 90 dB SPL in both the normal control and the OTOF patient with comparable amplitudes. In the normal control, the ECochG waveform resulting from CM cancellation at high intensity begins with an abrupt negative deflection, the SP, followed by a negative peak, the neural CAP (Eggermont, 1976;Elberling, 1976). Decreasing the stimulus level results in a gradual latency increase and amplitude reduction of both SP and CAP peaks.…”

Section: Cochlear Potentialsmentioning

confidence: 99%

“…In previous papers (Santarelli and Arslan, 2002;Santarelli et al, 2008), to clarify whether the prolonged potentials recorded in various forms of auditory neuropathy originate from neural or receptor activation, we used a high-rate adaptation procedure that preferentially attenuates neural responses by taking advantage of the different effects of high stimulation rates on neural and receptor potentials (Eggermont, 1976). The stimulus sequence consisted of an initial click, followed 15 ms later by ten clicks with an inter-stimulus interval of 2.9 ms, and the sequence was repeated every 191 ms .…”

Section: Cochlear Potentialsmentioning

confidence: 99%

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Audibility, speech perception and processing of temporal cues in ribbon synaptic disorders due to OTOF mutations

et al. 2015

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Mutations in the OTOF gene encoding otoferlin result in a disrupted function of the ribbon synapses with an impaired multivesicular glutamate release. Most affected subjects present with congenital hearing loss and abnormal auditory brainstem potentials associated with preserved cochlear hair cell activities (otoacoustic emissions, cochlear microphonics [CMs]). Transtympanic electrocochleography (ECochG) has recently been proposed for defining the details of potentials arising in both the cochlea and auditory nerve in this disorder, and with a view to shedding light on the pathophysiological mechanisms underlying auditory dysfunction.\ud We review the audiological and electrophysiological findings in children with congenital profound deafness carrying two mutant alleles of the OTOF gene. We show that cochlear microphonic (CM) amplitude, summating potential (SP) amplitude and latency are normal, consistently with a preserved outer and inner hair cell function. In the majority of OTOF children, the SP component is followed by a markedly prolonged low-amplitude negative potential by comparison with the compound action potential (CAP) recorded in normally-hearing children. This potential is identified at intensities as low as 90 dB below the behavioral threshold. In some ears, a synchronized CAP is superimposed on the prolonged responses at high intensity. Stimulation at high rates reduces the amplitude and duration of the prolonged potentials, consistently with their neural generation. In some children, however, the ECochG response only consists of the SP, with no prolonged potential. Cochlear implants restore hearing sensitivity, speech perception and neural CAP by electrically stimulating the auditory nerve fibers.\ud These findings indicate that an impaired multivesicular glutamate release in OTOF-related disorders leads to abnormal auditory nerve fiber activation and a consequent impairment of spike generation. The magnitude of these effects seems to vary, ranging from no auditory nerve fiber activation to an abnormal generation of EPSPs that occasionally trigger a synchronized electrical activity, resulting in high-threshold CAPs

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Section: Cochlear Potentialsmentioning

confidence: 99%

Section: Cochlear Potentialsmentioning

confidence: 99%

Section: Cochlear Potentialsmentioning

confidence: 99%

Section: Cochlear Potentialsmentioning

confidence: 99%

See 2 more Smart Citations

Audibility, speech perception and processing of temporal cues in ribbon synaptic disorders due to OTOF mutations

et al. 2015

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“…In the past, cochlear microphonics have been difficult to distinguish from the electrical artifact that often accompanies the generation of a stimulus at the transducer (Eggermont, 1976). This difficulty occurs because of the temporal proximity of the cochlear microphonic response to the onset of the stimulus and because the cochlear microphonic response so closely resembles the stimulating waveform.…”

Section: Cochlear Microphonicsmentioning

confidence: 99%

Auditory Neuropathy/Dys-synchrony and Its Perceptual Consequences

Rance

2005

Trends in Amplification

225

186

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Auditory neuropathy/dys-synchrony is a form of hearing impairment in which cochlear outer hair cell function is spared but neural transmission in the auditory pathway is disordered. This condition, or group of conditions with a common physiologic profile, accounts for approximately 7% of permanent childhood hearing loss and a significant (but as yet undetermined) proportion of adult impairment. This paper presents an overview of the mechanisms underlying auditory neuropathy/dys-synchrony-type hearing loss and the clinical profile for affected patients. In particular it examines the perceptual consequences of auditory neuropathy/dyssynchrony, which are quite different from those associated with sensorineural hearing loss, and considers currently available, and future management options.

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The relationship between round window and ear canal Cochlear microphonic

Liu

Antisdel

et al. 2022

Laryngoscope Investig Oto

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Hypothesis: Cochlear microphonic recorded at ear canal (CM-EC) can be a substitute for the one recorded at round window (CM-RW).Background: Almost all clinics do not measure tone-burst evoked CM due to technical difficulty although it can provide more information than click evoked CM. Moreover, clinicians like the CM-EC more than that measured at CM-RW because CM-EC is non-invasive. There is difference between CM-RW and CM-EC, for example, CM-EC is less prominent than CM-RW, therefore, studying tone-burst evoked CM-EC and its relationship with CM-RW are highly significant and can promote the clinical application of CM-EC.Method: Nine guinea pigs were randomly allocated into three groups, group 1 was not exposed to noise, called normal control. group 2 and group 3 were exposed to the low-(0.5-2 kHz) and high-frequency band-noise (6-8 kHz) at 120 dB SPL for 1 h, respectively. It was difficulty to record low-frequency CM due to severe environmental interruption, in current study the recording technology of tone-burst evoked CM

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Electrocochleography

Cited by 65 publications

References 58 publications

Audibility, speech perception and processing of temporal cues in ribbon synaptic disorders due to OTOF mutations

Audibility, speech perception and processing of temporal cues in ribbon synaptic disorders due to OTOF mutations

Auditory Neuropathy/Dys-synchrony and Its Perceptual Consequences

The relationship between round window and ear canal Cochlear microphonic

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