Electrochemotherapy for the Treatment of Recurrent Head and Neck                     Cancers: Preliminary Results

Mevio, Niccolò; Bertino, Giulia; Occhini, Antonio; Scelsi, Daniele; Tagliabue, Marta; Mura, F.; Benazzo, Marco

doi:10.1177/030089161209800305

Cited by 48 publications

(47 citation statements)

References 23 publications

(32 reference statements)

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“…Tumor sizes are very important in achieving a complete response. In particular, lesions with a major diameter lower than 3 cm showed a higher complete response rate, as previously described .…”

Section: Discussionsupporting

confidence: 82%

Efficacy of electrochemotherapy for eruptive legs keratoacanthomas

Ribero

Balagna

Baduel

et al. 2016

Dermatologic Therapy

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Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Even if skin cancers are usually well controlled with surgical and/or radiotherapic approaches, there are some cases in which these two techniques are not effective. With respect to surgery, radiotherapy and other standard treatments, ECT acts rapidly on multiple lesions with limited side effects and no functional impairment; moreover, repeated sessions can be performed to achieve or maintain the clinical response. We report a case of generalized eruptive keratoacanthomas in which electrochemotherapy was effective in inducing local regression of skin lesions. A 72-year-old woman with eruptive and painful keratoacanthomas for 3 months on both the lower limbs in which the conventional treatments could not be cosmetically acceptable. One session of electrochemotherapy with bleomycin sulfate was then performed on all isolated skin lesions. The treatment was well tolerated and led to a rapid clinical regression of the treated lesions. Use of ECT should be considered as an excellent alternative to current therapies in treatment of painful eruptive keratoacanthomas with a significant improvement of quality of life.

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Section: Discussionsupporting

confidence: 82%

Efficacy of electrochemotherapy for eruptive legs keratoacanthomas

Ribero

Balagna

Baduel

et al. 2016

Dermatologic Therapy

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Section: Discussionsupporting

confidence: 81%

Generalized eruptive keratoacanthomas of Grzybowski

Anzalone¹,

Cohen

2013

Int J Dermatology

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Generalized eruptive keratoacanthomas of Grzybowski is a rare form of keratoacanthoma and is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, ectropion, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Successful management of this condition has been observed in patients treated with systemic retinoids, such as acitretin.

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“…With ECT we were able to reach a good local tumour control, with no significant adverse events, nor functional or esthetic, which resulted in a good quality of the rest of her life. This case demonstrates that ECT can be considered as an effective palliative treatment option for patients with recurrent or advanced-stage tumour, not suitable for conventional treatments 10–14…”

Section: Discussionmentioning

confidence: 99%

Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region

Scelsi

Mevio²,

Bertino

et al. 2013

Radiology and Oncology

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BackgroundMerkel Cell Carcinoma (MCC) is a rare and aggressive tumour, arising from a cutaneous mechanoceptor cell located in the basal layer of epidermis, with poor prognosis. The treatment of choice for the initial stage of the disease is surgery and/or radiotherapy. The treatment of recurrent or advanced disease is still controversial.Case reportWe report a case of 84 years old woman with a recurrent MCC of the chin treated with electrochemotherapy (ECT). During the period of 20 months, four sessions of ECT were employed, which resulted in an objective response of the tumour and good quality of residual life.ConclusionsOur case shows the effectiveness of ECT in the treatment of locally advanced MCC of the head and neck region in a patient not suitable for standard therapeutic options.

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Electrochemotherapy for the Treatment of Recurrent Head and Neck Cancers: Preliminary Results

Abstract: Our study confirms the effectiveness of electrochemotherapy in the treatment or local control of recurrent or extended primary head and neck cancer in patients not suitable for standard therapeutic options.

Cited by 48 publications

References 23 publications

Efficacy of electrochemotherapy for eruptive legs keratoacanthomas

Efficacy of electrochemotherapy for eruptive legs keratoacanthomas

Generalized eruptive keratoacanthomas of Grzybowski

Electrochemotherapy as a new therapeutic strategy in advanced Merkel cell carcinoma of head and neck region

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