2016
DOI: 10.1111/dth.12374
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Efficacy of electrochemotherapy for eruptive legs keratoacanthomas

Abstract: Generalized eruptive keratoacanthoma, is considered a serious condition because the eruptions are diffuse, persistent, and recurrent. Constant pruritus, visceral neoplasms, and unsatisfactory response to treatment are ominous prognostic factors. Even if skin cancers are usually well controlled with surgical and/or radiotherapic approaches, there are some cases in which these two techniques are not effective. With respect to surgery, radiotherapy and other standard treatments, ECT acts rapidly on multiple lesio… Show more

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Cited by 12 publications
(11 citation statements)
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References 16 publications
(16 reference statements)
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“…ECT has been shown in clinical trials to have a high response rate in the treatment of patients with primary or metastatic skin cancers [ 8 ]. Interestingly, ECT has been already successfully used to treat eruptive KAs [ 12 ]. In the case presented here, the patient showed an excellent response to the ECT treatment and at the moment of writing this report is well.…”
Section: Discussionmentioning
confidence: 99%
“…ECT has been shown in clinical trials to have a high response rate in the treatment of patients with primary or metastatic skin cancers [ 8 ]. Interestingly, ECT has been already successfully used to treat eruptive KAs [ 12 ]. In the case presented here, the patient showed an excellent response to the ECT treatment and at the moment of writing this report is well.…”
Section: Discussionmentioning
confidence: 99%
“…Management can be challenging and evidence‐based treatment guidelines are lacking. Multiple off‐label options aimed at managing ulceration and destruction have been reported, including topical 5‐fluorouracil (5‐FU) and imiquimod, as well as intralesional 5‐FU, methotrexate and bleomycin, for which safety in OTR has not been determined . Topical 5‐FU under zinc oxide‐impregnated compression bandages (chemowraps) can be an effective treatment option .…”
Section: Management Of Eruptive Keratoacanthomas/cutaneous Squamous Cmentioning
confidence: 99%
“…Topical therapies include intralesional injection (5-fluorouracil, bleomycin, corticosteroids, methotrexate), topical use (retinoic acid, podophyllotoxin), operation, cryotherapy, radiation therapy and electrochemical treatment. 15 In the present case, oral acitretin was dramatically effective, while the mechanism was still unclear. Retinoic acid seems to inhibit keratinization, regulate terminal differentiation of epidermal cells and increase both IL-2 production and mitogen-induced lymphocyte proliferation.…”
Section: Discussionmentioning
confidence: 54%
“…Systemic therapies include: retinoic acid, cytostatic agents (methotrexate, cyclophosphamide, cyclosporine, α/γ‐interferon), epidermal growth factor receptor inhibitor (erlotinib), glucocorticoids and antihistamines. Topical therapies include intralesional injection (5‐fluorouracil, bleomycin, corticosteroids, methotrexate), topical use (retinoic acid, podophyllotoxin), operation, cryotherapy, radiation therapy and electrochemical treatment . In the present case, oral acitretin was dramatically effective, while the mechanism was still unclear.…”
Section: Discussionmentioning
confidence: 62%