Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues

Giardino, R.; Fini, Milena; Bonazzi, V.; Cadossi, Ruggero; Nicolini, Andrea; Carpi, Angelo

doi:10.1016/j.biopha.2006.07.016

Cited by 56 publications

(61 citation statements)

References 38 publications

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“…Some patients underwent up to three treatments because of new lesions, but maintained superficial tumor control. After a median follow-up of 12 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) months, only one patient experienced relapse in the treatment field, localized in the same treated site. Mapping of the lesions showed that disease was present in the vulva in 100% of cases.…”

Section: Resultsmentioning

confidence: 99%

“…In some cases, patients may have stable disease in sites other than the skin, and clinicians may be reluctant to use systemic chemotherapy for the skin metastases alone. Recently, ECT has been proposed as a novel, complementary therapeutic weapon for the control of superficial disease [3][4][5]. ECT is an effective local tumor ablation modality in the treatment of solid cancers, which combines the administration of no permeable or poorly permeable cytotoxic drugs with the application of electric pulses to the tumors to facilitate the drug delivery into the cancer cells.…”

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confidence: 99%

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Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer

et al. 2016

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer

et al. 2016

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“…Muitos quimioterápicos são estruturalmente constituídos por moléculas hidrófilas, exibindo assim restrição no transporte através da membrana celular. Contudo, uma vez simultaneamente administrados à eletroporação, exibem extrema potencialização do efeito terapêutico, em diminutas dosagens (Čemažar et al 2001, Gothelf et al 2003, Aminkov & Manov 2004, Giardino et al 2006, Serša et al 2006, Larkin et al 2007, Meschini et al 2012, Gibot et al 2013. Dentre os mencionados fár-macos, enfoque foi dado à amplificação da citotoxicidade exercida pela bleomicina, antibiótico com propriedade antitumoral, a qual, uma vez combinada à aplicação regional de pulsos elétricos, demonstra otimização de seus efeitos terapêuticos antitumorais (Čemažar et al 2001, Gothelf et al 2003, Serša et al 2006, Gibot et al 2013.…”

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Utilização de eletroquimioterapia para carcinoma de células escamosas tegumentar em felino

et al. 2016

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A eletroquimioterapia compreende a utilização conjunta de fármacos antineoplásicos e aplicação regional de pulsos elétricos (eletroporação), maximizando a concentração intracelular destes fármacos, assim propiciando maior ação citotóxica. A bleomicina, fármaco antimicrobiano dotado de propriedade antineoplásica, apresenta restrita penetrabilidade na membrana celular, dada a sua hidrossolubilidade. Todavia, uma vez administrada via intralesional ou intravenosa associada à eletroporação, demonstra citotoxicidade potencializada. Foram utilizados 21 felinos acometidos por carcinoma de células escamosas tegumentar. Padronizou-se o protocolo eletroquimioterápico empregando-se sulfato de bleomicina, pela via intravenosa, na dose de 15U/m 2 de superfície corpórea. A eletroporação foi perfilada com eletrodo composto por agulhas, pulsos elétricos com tensão de 1000 V, em onda quadrada unipolar, com duração de 100 microsegundos, totalizando oito ciclos. Verificou-se remissão neoplásica integral em 21 felinos inclusos no estudo (100%). Inexistiram complicações e/ou efeitos adversos decorrentes do procedimento. O protocolo avaliado neste trabalho revelou-se exequível, eficaz e seguro na terapêutica antineoplásica de carcinoma de células escamosas tegumentar felino.

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“…Investigations of ECT in a multicenter study, called European Standard Operating Procedures for Electrochemotherapy, demonstrate that over 80% of cutaneous and subcutaneous metastatic nodules can be healed by ECT (105). Also, the physical nature of electroporation allows the technique to be applied to any tissue.…”

Section: Electrochemotherapymentioning

confidence: 99%

Physical mechanisms and methods employed in drug delivery to tumors

Bešić¹

2007

Acta Pharmaceutica

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Physical mechanisms and methods employed in drug delivery to tumorsIn addition to several well-known drug delivery strategies developed to facilitate effective chemotherapy with anticancer agents, some new approaches have been recently established, based on specific effects arising from the applications of ultrasound, magnetic and electric fields on drug delivery systems. This paper gives an overview of newly developed methods of drug delivery to tumors and of the related anticancer therapies based on the combined use of different physical methods and specific drug carriers. The conventional strategies and new approaches have been put into perspective to revisit the existing and to propose new directions to overcome the threatening problem of cancer diseases.

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Electrochemotherapy a novel approach to the treatment of metastatic nodules on the skin and subcutaneous tissues

Cited by 56 publications

References 38 publications

Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer

Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer

Utilização de eletroquimioterapia para carcinoma de células escamosas tegumentar em felino

Physical mechanisms and methods employed in drug delivery to tumors

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