Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer

Pellegrino, A.; Damiani, Gianluca Raffaello; Mangioni, Costantino; Strippoli, Davide; Loverro, Giuseppe; Cappello, Antonio; Scd, Daniela Turoli; Corso, Silvia; Tartagni, Massimo; Pezzotta, Maria Grazia

doi:10.3109/0284186x.2015.1117134

Cited by 20 publications

(27 citation statements)

References 26 publications

(41 reference statements)

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“…Four studies encompassing 104 women with vulvar cancer were included in the review22–25 (Figure 1). The studies were published between 2013 and 2019.…”

Section: Resultsmentioning

confidence: 99%

“…The studies were published between 2013 and 2019. Three studies were prospective,23–25 while one study was partly prospective and retrospective 22. The methodological index for non-randomized studies was nine for all studies; hence, the included studies were of moderate quality (online supplementary table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Pooling of results from four studies22–25 encompassing 98 women rendered a summary proportion of 78.8% (95% CI 70.4% to 86.2%; Figure 2A) for overall response with no significant inter-study heterogeneity ( I 2 =0%, P=0.40; Figure 3). Pooling of results from four studies22–25 rendered a summary proportion of 48.7% (95% CI 30.7% to 61.50%; Figure 2B) for complete response with moderate inter-study heterogeneity ( I 2 =31.3%, P=0.22; Figure 3). Pooling of results from four studies22–25 rendered a summary proportion of 30.2% (95% CI 21.7% to 39.4%; Figure 2C) for partial response with no significant inter-study heterogeneity ( I 2 =0%, P=0.66; Figure 3).…”

Section: Resultsmentioning

confidence: 99%

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Use of electrochemotherapy in women with vulvar cancer to improve quality-of-life in the palliative setting: a meta-analysis

Tranoulis

Georgiou

Founta

et al. 2019

Int J Gynecol Cancer

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IntroductionElectrochemotherapy involves the use of transient tumor permeabilization via electric pulses in combination with low-dose chemotherapeutic agents. It has recently emerged as an alternative treatment modality in vulvar cancer. The aim of this meta-analysis was to ascertain the effectiveness of electrochemotherapy in the context of palliative care.MethodsThe following databases were searched: MEDLINE, Scopus, and Cochrane Database, to identify all registered articles pertaining to palliative vulvar cancer treatment with electrochemotherapy from inception until August 2019, in line with PRISMA guidelines. A single-proportion meta-analysis was performed for the outcomes of overall response, complete response, partial response, stable disease, and progressive disease raterespectively, using the random-effect model. Sensitivity analysis was performed to address heterogeneity.ResultsFour studies were included totaling 104 women. The studies were of moderate quality. Pooled results from four studies rendered a summary proportion of 78.8% (95% CI 70.4% to 86.1%) for the outcome of overall response. The median age ranged between 68 and 85 years. The sample size per study ranged between eight and 61 women. The tumors’ histological types included: squamous-cell carcinoma (96.2%), Paget’s disease (2.9%), and malignant melanoma (0.9%). A total of 65 patients (62.5%) presented with a single nodule, whilst 39 patients (37.5%) presented with multiple nodules. Eighty-nine women (85.6%) were previously submitted to other treatment modalities. The overall response rate ranged from 73.2% to 80.9%. The pooled proportion for the outcomes of complete and partial response rate was 48.7% (95% CI 30.74% to 61.5%) and 30.2% (95% CI 21.7% to 39.4%), respectively. The follow-up ranged from 1 to 51 months. No severe adverse effects were reported. The safety profile of electrochemotherapy was favorable.ConclusionsElectrochemotherapy is an effective and minimally invasive treatment modality in the palliative care management of patients with vulvar cancer. The effective control of vulvar tumors by electrochemotherapy may contribute to improvement of quality-of-life. In light of the moderate quality of evidence, a multi-center cooperation is warranted to confirm its palliative benefit.

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“…Four studies encompassing 104 women with vulvar cancer were included in the review22–25 (Figure 1). The studies were published between 2013 and 2019.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Use of electrochemotherapy in women with vulvar cancer to improve quality-of-life in the palliative setting: a meta-analysis

Tranoulis

Georgiou

Founta

et al. 2019

Int J Gynecol Cancer

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“…In this setting we recorded 52‐62% complete response (CR) rate and 12‐28% partial response (PR) rate without serious adverse events and with high levels of pain and other symptoms control . Pellegrino et al confirmed these promising results in the same clinical setting. All together, these three studies enrolled 35 patients with a 80% local disease response.…”

Section: Introductionmentioning

confidence: 64%

Electrochemotherapy pre‐treatment in primary squamous vulvar cancer. Our preliminary experience

Perrone

Galuppi

Borghese

et al. 2018

Journal of Surgical Oncology

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“…Thirteen patients (52%) achieved a CR, and 6-month LPFS and symptom-free survival (assessed by the Functional Assessment of Vulvar Cancer Therapy questionnaire) were 53% and 40%, respectively. Another Italian study investigated ECT on 10 highly elderly patients with recurrent disease all of whom had received multiple prior therapies [239] . A CR was achieved in 20%, a PR, in 40, and further ECT cycles led to an objective regression in 8 of 10 patients.…”

Section: Vulvar Carcinomamentioning

confidence: 99%

Electrochemotherapy of superficial tumors – Current status:

Campana

Miklavčič

Bertino

et al. 2019

Seminars in Oncology

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Outcomes of Bleomycin-based electrochemotherapy in patients with repeated loco-regional recurrences of vulvar cancer

Cited by 20 publications

References 26 publications

Use of electrochemotherapy in women with vulvar cancer to improve quality-of-life in the palliative setting: a meta-analysis

Use of electrochemotherapy in women with vulvar cancer to improve quality-of-life in the palliative setting: a meta-analysis

Electrochemotherapy pre‐treatment in primary squamous vulvar cancer. Our preliminary experience

Electrochemotherapy of superficial tumors – Current status:

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