Electrochemistry of Drug Interactions and Incompatibilities

Diffusional Electrochemical Catalytic (EC’) Mechanism Featuring Chemical Reversibility of Regenerative Reaction-Theoretical Analysis in Cyclic Voltammetry

“…[1,2,[7][8][9][10][11][12][13] Additionally, great efforts have been made in last couple of decades to comprehend the redox chemistry of many drugs, while relevant electrochemical methods were developed to get insight into the chemistry of drug-drug interactions. [3,4,7,14] To achieve these goals, many electrochemists have turned to cyclic voltammetry in order to evaluate relevant kinetics and thermodynamics parameters related to enzyme redox chemistry and the drug-drug interactions. [4,7,9,14] Cyclic voltammetry is recognized as the most valuable voltammetric technique, suitable for studying electrochemical and chemical features of many substances.…”

“…[3,4,7,14] To achieve these goals, many electrochemists have turned to cyclic voltammetry in order to evaluate relevant kinetics and thermodynamics parameters related to enzyme redox chemistry and the drug-drug interactions. [4,7,9,14] Cyclic voltammetry is recognized as the most valuable voltammetric technique, suitable for studying electrochemical and chemical features of many substances. [1][2][3][4][5][6][7][8][9]11,[14][15][16][17][18] The cyclic voltammetry allows us to get insight into chemical changes that occur during an electrochemical transformation of given "electroactive" substances at working electrode.…”

“…[4,7,9,14] Cyclic voltammetry is recognized as the most valuable voltammetric technique, suitable for studying electrochemical and chemical features of many substances. [1][2][3][4][5][6][7][8][9]11,[14][15][16][17][18] The cyclic voltammetry allows us to get insight into chemical changes that occur during an electrochemical transformation of given "electroactive" substances at working electrode. [7] Due to many efforts focused on the designing of sustainable voltammetric experimental methods for studying redox chemistry of enzymes and drugs, in the past three decades we witness great resurgence in the development of theories of cyclic voltammetry for studying various electrode mechanisms.…”

“…[7] Due to many efforts focused on the designing of sustainable voltammetric experimental methods for studying redox chemistry of enzymes and drugs, in the past three decades we witness great resurgence in the development of theories of cyclic voltammetry for studying various electrode mechanisms. [1,3,4,7,[9][10][11][12][13][14][15][16][17][18][19] The theoretical models in cyclic voltammetry can be explored to develop relevant methods for the determination of important kinetic and thermodynamic parameters related to the chemistry of many physiologically important substances. [4,7] In the family of electrode mechanisms that are complicated with chemical reactions, the socalled electrochemical-catalytic EC' mechanism is recognized as the most suitable model that provides insight into kinetic parameters relevant to interactions of many drugs, and the enzyme-substrate interactions as well.…”

Theoretical Analysis of a Surface Catalytic Mechanism Associated with Reversible Chemical Reaction Under Conditions of Cyclic Staircase Voltammetry

“…The catalytic EC' mechanism is physiologically relevant, since it is a valuable model to evaluate relevant chemical parameters related to many important enzyme-substrate systems [6][7][8]. Moreover, the surface EC' mechanism is also suitable to studying the kinetics of many drug-drug [1,2,9,28,29] and drug-DNA interactions [28][29][30][31][32][33][34][35][36]. In this electrode mechanism, a chemical and irreversible reaction between electrochemically created product Red(ads) with a defined substrate Y (that is present in excess) regenerates the initial reactant Ox(ads).…”