Electrochemiluminescent functional nucleic acids‐based sensors for food analysis

Xu, Huifeng; Zhu, Xi; Wang, Jian; Lin, Zhenyu

doi:10.1002/bio.3596

Cited by 14 publications

(5 citation statements)

References 111 publications

(139 reference statements)

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“…Food analysis shows great significance to prevent foodborne diseases, which are mainly generated from food-based contaminates, including biological and chemical hazards. , Functional metabolomics, proteomics, transcriptomics, and genomics have been applied as targets to understand the behavior of microorganisms in food safety. − The nucleic acid-based pathogen tests are also widely used to monitor and identify foodborne pathogens and food microbial ecology. Functional nucleic acids, such as aptamers and DNAzymes, coupled with novel nanoprobes and transducers, offer a variety of tests for foodborne contaminant monitoring. − These tests achieved sensitive, specific, and rapid tests of pathogens, allergens, mycotoxins, illegal additives, allergens, heavy metal ions, and pesticides with a great potential in POC tests.…”

Section: Other Applications Of Natsmentioning

confidence: 99%

Nucleic Acid Tests for Clinical Translation

et al. 2021

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Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are natural biopolymers composed of nucleotides that store, transmit, and express genetic information. Overexpressed or underexpressed as well as mutated nucleic acids have been implicated in many diseases. Therefore, nucleic acid tests (NATs) are extremely important. Inspired by intracellular DNA replication and RNA transcription, in vitro NATs have been extensively developed to improve the detection specificity, sensitivity, and simplicity. The principles of NATs can be in general classified into three categories: nucleic acid hybridization, thermal-cycle or isothermal amplification, and signal amplification. Driven by pressing needs in clinical diagnosis and prevention of infectious diseases, NATs have evolved to be a rapidly advancing field. During the past ten years, an explosive increase of research interest in both basic research and clinical translation has been witnessed. In this review, we aim to provide comprehensive coverage of the progress to analyze nucleic acids, use nucleic acids as recognition probes, construct detection devices based on nucleic acids, and utilize nucleic acids in clinical diagnosis and other important fields. We also discuss the new frontiers in the field and the challenges to be addressed.

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Section: Other Applications Of Natsmentioning

confidence: 99%

Nucleic Acid Tests for Clinical Translation

et al. 2021

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“…The above-mentioned nucleic acid-based pathogen analysis techniques are also widely used to detect and identify foodborne pathogens and to study food microbial ecology [458,459]. Functional nucleic acids, coupled with novel transducers and nanoprobes, offer a variety of biosensors for foodborne contaminant detection [460][461][462]. These biosensors have achieved rapid and sensitive detection of pathogens ( Figure 19(a)) [463], mycotoxins (Figure 19(b)) [464,465], allergens [468], pesticides [467], heavy metal ions [468] and illegal additives [469], with a great application potential in POCT.…”

Section: Food Analysismentioning

confidence: 99%

Nucleic Acids Analysis

Zhao

Zuo

et al. 2020

Sci. China Chem.

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In recent years, multi-modal entity linking (MEL) has garnered increasing attention in the research community due to its significance in numerous multi-modal applications. Video, as a popular means of information transmission, has become prevalent in people's daily lives. However, most existing MEL methods primarily focus on linking textual and visual mentions or offline videos's mentions to entities in multi-modal knowledge bases, with limited efforts devoted to linking mentions within online video content. In this paper, we propose a task called Online Video Entity Linking (OVEL), aiming to establish connections between mentions in online videos and a knowledge base with high accuracy and timeliness. To facilitate the research works of OVEL, we specifically concentrate on live delivery scenarios and construct a live delivery entity linking dataset called LIVE. Besides, we propose an evaluation metric that considers timelessness, robustness, and accuracy. Furthermore, to effectively handle OVEL task, we leverage a memory block managed by a Large Language Model and retrieve entity candidates from the knowledge base to augment LLM performance on memory management. The experimental results prove the effectiveness and efficiency of our method.

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“…However, these methods are time‐consuming, require professional personnel to operate, and are complicated and costly to maintain. Additionally, the acquisition of ELIZA antibodies involves ethical issues as well as instability of monoclonal antibodies (Xu et al, 2019). The shortcomings of these traditional methods greatly limit the ability to analyze pollutants in the field.…”

Section: Introductionmentioning

confidence: 99%

Research progress in the detection of common foodborne hazardous substances based on functional nucleic acids biosensors

Chen,

Liu,

Liu

et al. 2023

Biotech & Bioengineering

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With the further improvement of food safety requirements, the development of fast, highly sensitive, and portable methods for the determination of foodborne hazardous substances has become a new trend in the food industry. In recent years, biosensors and platforms based on functional nucleic acids, along with a range of signal amplification devices and methods, have been established to enable rapid and sensitive determination of specific substances in samples, opening up a new avenue of analysis and detection. In this paper, functional nucleic acid types including aptamers, deoxyribozymes, and G‐quadruplexes which are commonly used in the detection of food source pollutants are introduced. Signal amplification elements include quantum dots, noble metal nanoparticles, magnetic nanoparticles, DNA walkers, and DNA logic gates. Signal amplification technologies including nucleic acid isothermal amplification, hybridization chain reaction, catalytic hairpin assembly, biological barcodes, and microfluidic system are combined with functional nucleic acids sensors and applied to the detection of many foodborne hazardous substances, such as foodborne pathogens, mycotoxins, residual antibiotics, residual pesticides, industrial pollutants, heavy metals, and allergens. Finally, the potential opportunities and broad prospects of functional nucleic acids biosensors in the field of food analysis are discussed.

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Electrochemiluminescent functional nucleic acids‐based sensors for food analysis

Cited by 14 publications

References 111 publications

Nucleic Acid Tests for Clinical Translation

Nucleic Acid Tests for Clinical Translation

Nucleic Acids Analysis

Research progress in the detection of common foodborne hazardous substances based on functional nucleic acids biosensors

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