Electrochemically modulated transport through a conducting polymer membrane

Pile, Donald; Hillier, Andrew C.

doi:10.1016/s0376-7388(02)00204-1

Cited by 36 publications

(32 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[3,21,22] In all cases, there is a fairly good resemblance between the experimental findings and model predictions. This shows the accuracy of the model predictions for the cases with molecular release through CP films.…”

Section: Validation With Related Experimental Findingsmentioning

confidence: 55%

“…As mentioned, experimental proof of such membrane operation has already been shown by other researchers. [3,21,22] The mathematical framework for analyzing the process consists of the Nernst-Planck (NP) equations with an ionic reaction term and the Poisson equation for describing the electric field, thus completing the PNP framework. The conventional form of the one-dimensional Poisson equation is Equation (1):…”

Section: System and Modeling Frameworkmentioning

confidence: 99%

See 1 more Smart Citation

Ionic Ingress and Charge‐Neutralization Phenomena of Conducting‐Polymer Films

Majumdar¹,

Rây

Kargupta

et al. 2010

ChemPhysChem

View full text Add to dashboard Cite

Ionic ingress and diffusion through a conducting-polymer (CP) film containing embedded charges under potential and concentration gradients is studied. Electroneutrality, a common assumption in modeling of similar systems, is not justified in this case or similar diffusion-limited processes, as the timescale of ionic diffusion in the solid matrix is quite large. Counter ions therefore cannot move instantaneously for effective neutralization of excess charges. Poisson-Nernst-Planck (PNP) equations have to be solved for such cases without any simplifying assumption. Analytical solution shows the existence of a charge boundary layer, which limits and strongly influences the ionic flux. A general numerical method for solution is also developed for the dynamic modeling, analysis, and design of these types of systems. The numerical results are validated by comparison with analytical solutions as well as with some experimental results available in the literature. With this modeling framework, the basic features of controlled release of molecules across a CP film under an applied electrical potential can be explained quantitatively.

show abstract

Section: Validation With Related Experimental Findingsmentioning

confidence: 55%

Section: System and Modeling Frameworkmentioning

confidence: 99%

Ionic Ingress and Charge‐Neutralization Phenomena of Conducting‐Polymer Films

Majumdar¹,

Rây

Kargupta

et al. 2010

ChemPhysChem

View full text Add to dashboard Cite

show abstract

“…With these redox‐active nanotubes, excess cationic charge is placed on the membrane by using the potential applied to the membrane to drive the following redox reaction:8–11 It was found that when the nanotube‐bound Fc is oxidized to Fc + , the flux of a cationic permeate species is suppressed relative to Fc in its reduced state. While similar results have been achieved using membranes composed of redox‐active conductive polymers,12–14 this paradigm for gating ion transport has not been demonstrated for redox‐active nanotube membranes. The results of such redox‐modulated transport experiments are described here.…”

Section: Flux and Electromodulated Selectivity Coefficients ($\Alpha$mentioning

confidence: 79%

Electroactive Nanotube Membranes and Redox‐Gating

Büyükserin

Kohli

Wirtz

et al. 2007

Small

View full text Add to dashboard Cite

show abstract

“…Some literatures report that CP film/membrane loses conductivity or efficiency of delivering molecules with large number of voltage cycles. This is sometimes attributed to hydrolysis reaction associated with partial irreversibility of interconversion between the two desired oxidation states [21]. The mechanism by which high retention causes membrane deterioration is not well established, but it is safer to operate with as little retention as possible.…”

Section: Introductionmentioning

confidence: 99%

Studies on the performance of the conducting polymer‐based molecular release system

Majumdar¹,

Kargupta²,

Ganguly³

et al. 2011

Polymer Engineering & Sci

View full text Add to dashboard Cite

‘Conducting polymeric (CP) membrane based controlled molecular release under applied electrical potential’ is an important futuristic application in ‘drug delivery’. A validated Poisson‐Nernst‐Planck based framework has been used in this study for the purpose of performance mapping for such a system. Leaking of the molecules during loading time and retention of molecules at the end of each voltage cycle have been identified here as the major bottlenecks in the use of this system in a sustainable basis. Peak flux of ionic molecules delivered is a key objective to be maximized along with minimum retention and leakage. Results reveal that parameters like time of voltage span, effective diffusivity, polymer film thickness need to be tightly maintained. At the same time, a wide variety of CP‐drug combinations can be acceptable. This opens the possibilities of utilizing this system for large range of therapeutic applications for controlled drug delivery. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers

show abstract

Electrochemically modulated transport through a conducting polymer membrane

Cited by 36 publications

References 56 publications

Ionic Ingress and Charge‐Neutralization Phenomena of Conducting‐Polymer Films

Ionic Ingress and Charge‐Neutralization Phenomena of Conducting‐Polymer Films

Electroactive Nanotube Membranes and Redox‐Gating

Studies on the performance of the conducting polymer‐based molecular release system

Contact Info

Product

Resources

About