Electrochemically Enabled Intramolecular and Intermolecular Annulations of Alkynes

Sun, Kai; Liu, Jia; Liu, Yingjie; Liu, Bing; Chen, Ning

doi:10.1002/adsc.202000876

Cited by 47 publications

(9 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 世纪, Faraday [1] 实现了乙酸电解制烃, Kolbe [2] 实现了电化学脱羧二聚, Schoenbein [3] 实现了三氯甲基磺酸的还原脱卤, 从而开创了电化学有机合成领域 [4][5] . 电化学反应通常发生在电极上, 电子充当氧化还原剂, 分子通过得到或者失去电子, 在阳极发生氧化反应或者在阴极发生还原反应(Figure 1).…”

Section: 电化学unclassified

Research Progress of Photoelectric Co-catalysis

Liu¹,

Wang²,

Meng³

et al. 2022

Chinese Journal of Organic Chemistry

Self Cite

View full text Add to dashboard Cite

Photochemical and electrochemical reactions, which are mild and green, have been widely used in organic synthesis in recent years. To push the limits of both synthetic technologies, organic chemists have focused on using these two strategies to promote organic transformation in a single reaction system. A series of photoelectrochemical strategies have been developed, and the main one at present is electrochemically mediated photoredox catalysis. In addition, photoexcitation-assisted electroredox strategies have also gradually shown their potential in organic synthesis. These strategies realize the complementary advantages and disadvantages of photochemistry and electrochemistry, and can solve the problems that can not be solved by a single synthetic technology, such as removing oxidizing reducing agents that complicate the reaction, generating intermediates with high activity under mild conditions, and so on. In this paper, the research progress of photoelectrochemical strategies is summarized according to the existing photoelectric catalysis reactions, and the possible mechanism of some reactions is discussed.

show abstract

Section: 电化学unclassified

Research Progress of Photoelectric Co-catalysis

Liu¹,

Wang²,

Meng³

et al. 2022

Chinese Journal of Organic Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Photochemistry and electrochemistry, new technologies developed in recent years, can be used as powerful synthetic tools for the economical, environmentally friendly construction of heterocyclic compounds. [80,81] In 2016, Wu and his colleagues reported a mild, economical, and efficient method for the synthesis of 1,3,5-trisubstituted pyrazoles 308 via a tandem reaction of hydrazones with α-bromo ketones 307. The reaction is mediated by visible light (Scheme 48).…”

Section: Visible Light and Electrochemically Enabled Cyclization Of Hydrazones With Unsaturated Systemsmentioning

confidence: 99%

Update on the Synthesis of N‐Heterocycles via Cyclization of Hydrazones (2017–2021)

Meng

et al. 2021

Adv Synth Catal

Self Cite

View full text Add to dashboard Cite

Hydrazones, as universal structural units, are useful synthons for the formation of carbonnitrogen and nitrogenÀ heteroatom bonds. Thus, they provide new methods of constructing nitrogen-containing heterocycles. In recent years, especially between 2017 and 2021, many efforts have been made to exploit hydrazone-based reactions in efforts to develop more powerful and effective pathways towards the synthesis of various multifunctional heterocyclic compounds. However, despite the tremendous amount of work that has been published over the past five years, no review has been published that summarizes the significant progress in the preparation of nitrogen heterocycles via intramolecular cyclization of hydrazones with adjacent unsaturated bonds or intermolecular cyclization of hydrazones with unsaturated systems. Therefore, this review summarizes the hydrazone-based cyclization strategies used to synthesize nitrogen-containing heterocycles over the past five years. It discusses the corresponding reaction scopes, limitations, mechanisms, and problems. Cyclization of Hydrazones with Unsaturated Systems 3.3. Cyclization of Hydrazones with Unsaturated Systems Under Metal-Free Conditions 4. Conclusion

show abstract

“…We herein report that the C–O/N–H annulation of aromatic amides with alkynes results in the production of isoquinolinones (Scheme 1). 4,5 Remarkably, the reaction was also applicable to C–S/N–H and C–CN/N–H annulation, which proceed via C–S and C–CN bond activation.…”

Section: Introductionmentioning

confidence: 96%