Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

Ramanavičius, Simonas; Morkvėnaitė-Vilkončienė, Inga; Samukaitė-Bubnienė, Urtė; Ratautaitė, Vilma; Plikusienė, Ieva; Viter, Roman; Ramanavičius, Arūnas

doi:10.3390/s22031282

Cited by 43 publications

(28 citation statements)

References 252 publications

(345 reference statements)

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“…Sensors 2022, 21, x FOR PEER REVIEW 3 of 14 selectivity with excellent potential for bacterial analysis in food samples. A more in-depth review of MIP-based electrochemical sensors can be referred to in previous works [44][45][46][47].…”

Section: Methodsmentioning

confidence: 99%

Biosensors for Klebsiella pneumoniae with Molecularly Imprinted Polymer (MIP) Technique

Pintavirooj

Vongmanee

Sukjee

et al. 2022

Sensors

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Nosocomial infection is one of the most important problems that occurs in hospitals, as it directly affects susceptible patients or patients with immune deficiency. Klebsiella pneumoniae (K. pneumoniae) is the most common cause of nosocomial infections in hospitals. K. pneumoniae can cause various diseases such as pneumonia, urinary tract infections, septicemias, and soft tissue infections, and it has also become highly resistant to antibiotics. The principal routes for the transmission of K. pneumoniae are via the gastrointestinal tract and the hands of hospital personnel via healthcare workers, patients, hospital equipment, and interventional procedures. These bacteria can spread rapidly in the hospital environment and tend to cause nosocomial outbreaks. In this research, we developed a MIP-based electrochemical biosensor to detect K. pneumoniae. Quantitative detection was performed using an electrochemical technique to measure the changes in electrical signals in different concentrations of K. pneumoniae ranging from 10 to 105 CFU/mL. Our MIP-based K. pneumoniae sensor was found to achieve a high linear response, with an R2 value of 0.9919. A sensitivity test was also performed on bacteria with a similar structure to that of K. pneumoniae. The sensitivity results show that the MIP-based K. pneumoniae biosensor with a gold electrode was the most sensitive, with a 7.51 (% relative current/log concentration) when compared with the MIP sensor applied with Pseudomonas aeruginosa and Enterococcus faecalis, where the sensitivity was 2.634 and 2.226, respectively. Our sensor was also able to achieve a limit of detection (LOD) of 0.012 CFU/mL and limit of quantitation (LOQ) of 1.61 CFU/mL.

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Section: Methodsmentioning

confidence: 99%

Biosensors for Klebsiella pneumoniae with Molecularly Imprinted Polymer (MIP) Technique

Pintavirooj

Vongmanee

Sukjee

et al. 2022

Sensors

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“…Electropolymerization can be achieved mainly either potentiodynamically (by CV) or potentiostatically [72] (by applying to the electrode a given potential for a well-established time). The thickness and the porosity of the MIP film at the transducer surface can be controlled by the proper selection of the applied voltage, the scan rate, the number of scans [8,24,95] and potential range (in the CV procedure), the deposition time as well as the monomer and template concentration [124], as it was carried out for the preparation of MMZ-imprinted polypyrrole [99]. This rapid and sensitive method is used when expensive or very small amounts of template molecules are available.…”

Section: Polymerization Proceduresmentioning

confidence: 99%

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

et al. 2022

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Antibiotics are antibacterial agents applied in human and veterinary medicine. They are also employed to stimulate the growth of food-producing animals. Despite their benefits, the uncontrolled use of antibiotics results in serious problems, and therefore their concentration levels in different foods as well as in environmental samples were regulated. As a consequence, there is an increasing demand for the development of sensitive and selective analytical tools for antibiotic reliable and rapid detection. These requirements are accomplished by the combination of simple, cost-effective and affordable electroanalytical methods with molecularly imprinted polymers (MIPs) with high recognition specificity, based on their “lock and key” working principle, used to modify the electrode surface, which is the “heart” of any electrochemical device. This review presents a comprehensive overview of MIP-modified carbon-based electrodes developed in recent years for antibiotic detection. The MIP preparation and electrode modification procedures, along with the performance characteristics of sensors and analytical methods, as well as the applications for the antibiotics’ quantification from different matrices (pharmaceutical, biological, food and environmental samples), are discussed. The information provided by this review can inspire researchers to go deeper into the field of MIP-modified sensors and to develop efficient means for reliable antibiotic determination.

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“…For this purpose, milder imprinting techniques such as soft lithography and electropolymerization have been exploited. Both techniques have been utilized both for proteins and viruses [ 20 , 37 , 55 , 56 , 82 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ].…”

Section: Molecularly Imprinted Polymersmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

Yarman

Kurbanoğlu

2022

Biomimetics

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Since the first reported case of COVID-19 in 2019 in China and the official declaration from the World Health Organization in March 2021 as a pandemic, fast and accurate diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has played a major role worldwide. For this reason, various methods have been developed, comprising reverse transcriptase-polymerase chain reaction (RT-PCR), immunoassays, clustered regularly interspaced short palindromic repeats (CRISPR), reverse transcription loop-mediated isothermal amplification (RT-LAMP), and bio(mimetic)sensors. Among the developed methods, RT-PCR is so far the gold standard. Herein, we give an overview of the MIP-based sensors utilized since the beginning of the pandemic.

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Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors

Cited by 43 publications

References 252 publications

Biosensors for Klebsiella pneumoniae with Molecularly Imprinted Polymer (MIP) Technique

Biosensors for Klebsiella pneumoniae with Molecularly Imprinted Polymer (MIP) Technique

Recent Trends in the Development of Carbon-Based Electrodes Modified with Molecularly Imprinted Polymers for Antibiotic Electroanalysis

Molecularly Imprinted Polymer-Based Sensors for SARS-CoV-2: Where Are We Now?

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