Electrochemical tracking hydrogen peroxide secretion in live cells based on autocatalytic oxidation reaction of silver nanoparticles

Optically activated and interrogated plasmonic hydrogels for applications in wound healing

“…We found that aqueous suspensions of PEGylated Au/Ag core/shell nanorods enjoy substantial stability in an aqueous environment. However, in the presence of H 2 O 2 , Ag shells tend to undergo oxidative dissolution over a time scale that depends on peroxide concentration [30][31][32][33][34][35][36]. In Supporting Information, we give an idea of the kinetics of this reaction, which starts rather slow, but then suddenly accelerates until complete etching of the Ag shell down to its interface with Au.…”

“…But the combination of optical and redox behavior of these materials may serve even more tasks of interest in wound healing. This is the case for the assessment of oxidative stress by the measurement of the rate of oxidative dissolution of Ag nanoparticles [29][30][31][32][33][34][35][36].…”

“…In spite of its importance, the determination of oxidative stress in vivo is difficult, and has been subject to indirect analyses of oxidation products, such as lipids, proteins or DNA [54,55]. In this context, Ag nanospheres have attracted attention as an ideal case of optical tags, because their rate of oxidative dissolution increases with the environmental concentration of ROS [29][30][31][32][33][34][35][36]. It is unfortunate that the plasmonic band of Ag nanospheres falls in the blue window, which is problematic for biomedical applications and limits the depth of optical penetration to few hundreds microns.…”

Silver Doped Mesoporous Silica Nanoparticles Based Electrochemical Enzyme-Less Sensor for Determination of H2O2 Released from Live Cells

“…Several analytical methods such as spectrophotometry [3], fluorimetry [4], titrimetry [5], chromatography [6], and electrochemistry [7,8] have been applied for highly sensitive H 2 O 2 determination. Amongst the above techniques, electrochemical methods are always optimal choices, due to their high sensitivity, operational simplicity, fast response, low cost, portability, and multi-analyte detection [9,10]. However, most electrode modifiers possessed high potentials, which limited the sensitive and selective performance of H 2 O 2 at ordinary solid electrodes [11].…”

H2O2-Responsive Nanoparticle Based on the Supramolecular Self-Assemble of Cyclodextrin

“…For cancer therapy, diverse intracellular and extracellular endogenous stimuli within tumor microenvironment, such as low pH value, hypoxia, enzymes and reactive oxygen species (ROS) have been widely investigated in stimuli responsive NPs and explored as the stimuli to selectively trigger drug control release or transfer prodrug systems into active form ( Chen et al, 2015 ; Ruan et al, 2015 , 2016 ; Liao et al, 2016 ; Wang et al, 2017b ). As an important hallmark, it should be noticed that various studies have demonstrated that hydrogen peroxide (H 2 O 2 ) could be used as a second messenger in intracellular signaling cascades and would be generated in multiple skin lesions, initiating aging cells and the tumoral tissue ( Miao et al, 2015 ). In this regard, H 2 O 2 -responsive NPs would be a promising therapeutic strategy for the treatment of specific disease.…”