Electrochemical synthesis and catalytic activity of organonickel sigma-complexes

Yakhvarov, Dmitry G.; Trofimova, E. A.; Ризванов, И. Х.; Fomina, Olga S.; Sinyashin, Оleg G.

doi:10.1134/s1023193511100247

Cited by 32 publications

(23 citation statements)

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“…Furthermore, studying a cascade of reactions requires similar methodologies whatever the scope, biological or chemical. The electrochemical determination of mechanisms encountered in organometallic catalysis has been widely reviewed for metals like palladium [48], cobalt [49] and nickel [50], an inspiring approach to address the redox metabolism of bioorganometallic drugs.…”

Section:  Organometallic Drugsmentioning

confidence: 99%

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Buriez

Labbé

2020

Current Opinion in Electrochemistry

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Electrochemical methods provide a wide range of strategies to explore the metabolism of drugs. These approaches traditionally encompass preparative aspects viz. the electrochemical generation of potent metabolites or the electrochemical exploration of the reactivity of redox enzymes (or their mimics) towards drugs. More recently the electroanalytical characterization of the successive redox and redoxcoupled reactions was found effective to unravel more complex mechanisms, especially those related to the reactivity of bioorganometallic drugs. This minireview highlights the contribution of these different electrochemical strategies to the determination of drug metabolism through representative recent examples.

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Section:  Organometallic Drugsmentioning

confidence: 99%

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Buriez

Labbé

2020

Current Opinion in Electrochemistry

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“…To study the reactivity of organonickel sigma complexes of type [NiX(Ar)(bpy)] towards the P 4 molecule, the electrochemical synthesis of stable organonickel sigma‐bonded complexes 1 – 3 has been elaborated (Scheme ) 28,29…”

Section: Electrochemical Synthesis Of Organophosphorus Compoundsmentioning

confidence: 99%

Electrode Reactions of Elemental (White) Phosphorus and Phosphane PH₃

2013

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Electrochemical methods have become important from the viewpoint of the development and creation of new ecologically safe and resource‐saving chemical processes. The use of electrons as a “universal” and “inexhaustible” reagent for chemical reactions is the main advantage of electrochemical tools. Although electrochemical processes have been already successfully applied in the preparation of different classes of practically important chemical compounds, a very limited number of industrially applicable electrochemical processes that involve elemental (white) phosphorus is currently known, except for some examples of the electrochemical production of phosphane PH3. These are mainly associated with the investigation of bulk reactions of the electrochemically activated P4 molecule and phosphorus intermediates derived therefrom; very limited attention has been paid to the electrode surface reactions as a key stage of the electrochemical process. In this Microreview we describe the electrode reactions of elemental (white) phosphorus and phosphane that accompany the electrochemical process of the preparation of some phosphorus compounds starting directly from P4. The important role of the nature of the electrode material, the reactivity of the formed phosphorus intermediates and the surface processes are discussed. Moreover, recently, we succeeded in discovering a new, previously unstable phosphorus compound, phosphane oxide H3PO, which can be easily produced using an electrochemical method by mild anodic oxidation of phosphane PH3 electrochemically formed from P4. In this respect, some attention has been paid to the electrochemically induced processes of PH3 oxidation that result in the selective formation of phosphane oxide, which is of high interest from the viewpoint of the investigation of its properties and reactivity.

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“…[22] White phosphorus (70 mg, 0.56 mmol) was suspended in H 2 O/EtOH 2:1 (30 mL) and warmed to 60 8C under nitrogen to ensure dissolution (ca. 30 min).…”

Section: Methodsmentioning

confidence: 99%

Experimental Evidence of Phosphine Oxide Generation in Solution and Trapping by Ruthenium Complexes

et al. 2011

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Electrochemical synthesis and catalytic activity of organonickel sigma-complexes

Cited by 32 publications

References 15 publications

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Electrode Reactions of Elemental (White) Phosphorus and Phosphane PH₃

Experimental Evidence of Phosphine Oxide Generation in Solution and Trapping by Ruthenium Complexes

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Electrochemical synthesis and catalytic activity of organonickel sigma-complexes

Cited by 32 publications

References 15 publications

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Electrode Reactions of Elemental (White) Phosphorus and Phosphane PH3

Experimental Evidence of Phosphine Oxide Generation in Solution and Trapping by Ruthenium Complexes

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Electrode Reactions of Elemental (White) Phosphorus and Phosphane PH₃