Electrochemical study of ivabradine hydrochloride ion selective electrodes using different ionophores

Abo-Talib, Nisreen F.; Tammam, Marwa Hosny; Attia, Ali K.

doi:10.1039/c5ra21033j

Cited by 7 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using SSM, better selectivity of the MIP-based electrode (sensor 5) over the NIP-based electrode (sensor 6) was noticed according to the selectivity coefficients attained. It is shown in Figure 10 that the selectivity of sensor 5 is improved over that of sensor 6 by more than an order of magnitude, and over previously reported sensor 2 ( Abo-Talib et al, 2015 ) by about two orders of magnitude. This indicates that the interaction not only is based on hydrogen bonding as in the case of NIP3 but also depends mainly on the specific recognition binding cavities of the MIP3 selective for IVR ( Hummers and Offeman, 1958 ; Masotti and Caporali, 2013 ; Bai and Zhou, 2014 ).…”

Section: Resultsmentioning

confidence: 57%

“…The binding strength between the ionophore as a host and the IVR analyte as a guest was estimated potentiometrically using the sandwich membrane method (SMM), for the first time in the case of MIP ionophore-based ion-selective electrode (ISEs). Besides, modification with MIP as ionophore improved the sensitivity and selectivity toward IVR in comparison to other previously reported IVR sensors due to the selective recognition properties of MIPs compared to other traditional modifiers ( Abo-Talib et al, 2015 ; Abdel-Haleem et al, 2020 ). The matched potential method (MPM) was performed to ensure the results of the SSM and to measure the selectivity of neutral interfering ions that cannot be measured using the SSM.…”

Section: Introductionmentioning

confidence: 73%

“… Selectivity coefficient values of sensor 5 and sensor 6 from this work against sensor 6 in reference ( Abo-Talib et al, 2015 ) against different interfering species calculated by (A) the SSM method and (B) the MMS method. …”

Section: Resultsmentioning

confidence: 99%

“…Based on the literature, IVR was determined potentiometrically using PVC membrane electrodes incorporating sulfonated calixarene and hydroxypropyl-ß-cyclodextrin ( Abo-Talib et al, 2015 ) which exhibited low to moderate selectivity. Yet, no MIP (ionophore) as ionophore has been reported for IVR determination.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Molecularly Imprinted Electrochemical Sensor-Based Fe2O3@MWCNTs for Ivabradine Drug Determination in Pharmaceutical Formulation, Serum, and Urine Samples

Abdel‐Haleem

Gamal

Rizk

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Ivabradine hydrochloride (IVR) is a medically important drug because of its ability to lower the heart rate. Techniques reported for IVR determination were expensive, laborious, besides being of poor selectivity. In this study, iron oxide @ carbon nanotube (Fe2O3@MWCNTs) nanocomposite and molecularly imprinted polymer (MIP) were synthesized and used in the fabrication of carbon paste electrodes (CPEs) for the potentiometric detection of IVR in biological and pharmaceutical samples. CPEs of the best sensor were formulated from graphite (41 wt%) as a carbon source, MIP (3 wt.%) as an ionophore, Fe2O3@MWCNTs (5 wt%) as a modifier, and nitrophenyl octyl ether (NPOE, 51 wt.%) as a conductive oil so-called plasticizer. The best sensor exhibits a Nernstian slope (response) of 56 mV decade–1 within the IVR concentration range from 1.0 × 10–3 M to 9.8 × 10–8 M with high selectivity against interfering species (ascorbic, maltose, glucose, lactose, dopamine, glycine) over those reported earlier. The use of Fe2O3@MWCNTs together with MIP in the electrode formulation was found to improve the limit of detection (LOD) from 630 to 98 nM along with high reversibility, a short response time of 30 s, and a good lifetime of more than 2 weeks. The sandwich membrane (SMM) method was used to quantify the H-bonding complexing strength of the MIP binding sites for IVR with Log βILn = 11.33. The constructed sensors were successfully applied for the IVR determination in blood serum, urine, and commercial formulations (Savapran®) with high sensitivity.

show abstract

Section: Resultsmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecularly Imprinted Electrochemical Sensor-Based Fe2O3@MWCNTs for Ivabradine Drug Determination in Pharmaceutical Formulation, Serum, and Urine Samples

Abdel‐Haleem

Gamal

Rizk

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Several methods have been reported to determine IH such as spectrophotometric method, 4 chromatographic methods, 4 - 11 spectrofluorimetric method, 12 and potentiometric method. 13 …”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Ivabradine Hydrochloride Using Multiwalled Carbon Nanotubes Modified Electrode in Presence of Sodium Dodecyl Sulfate

Attia¹,

Abo-Talib²,

Tammam³

2017

Adv Pharm Bull

View full text Add to dashboard Cite

Purpose: A new sensitive sensor was fabricated for the determination of ivabradine hydrochloride (IH) based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase the sensitivity. Methods: The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic and differential pulse voltammetry. Results: The voltammetric response was linear over the range of 3.984 x 10-6-3.475 x 10-5 mol L-1. The limits of detection and quantification were found to be 5.160 x 10-7 and 1.720 x 10-6 mol L-1, respectively. Conclusion: This method is suitable for determination of IH in tablets and plasma.

show abstract

Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

Pan

Guo

2020

Angewandte Chemie

View full text Add to dashboard Cite

Calixarene (CAs) stellen die dritte Generation supramolekularer Wirtsstrukturen dar und sind eine der am häufigsten untersuchten makrocyclischen Gerüststrukturen. Sie bieten aufgrund ihrer einfachen Modifikation (fast) unbegrenzte Möglichkeiten, um große Molekülbibliotheken als Materialbasis für vielfältige biomedizinische Anwendungen zu etablieren. Darüber hinaus beteiligen sich CAs und ihre Derivate an verschiedenen nichtkovalenten Interaktionen zur einfachen Erkennung von Gaststrukturen, einschließlich bioaktiver Moleküle, und sind auch wichtige Bausteine für die Herstellung supramolekularer Architekturen. Im Hinblick auf ihre molekularen Erkennungs‐ und Selbstorganisationseigenschaften werden CAs in großem Umfang in der Biosensorik, dem Bioimaging und im Wirkstoff‐/Gentransport eingesetzt. Weiterhin weisen einige CA‐Derivate biologische Aktivitäten auf und können daher als neue Therapeutika eingesetzt werden. Wir fassen hier die vielfältigen biomedizinischen Anwendungen von CAs zusammen, einschließlich der In‐vitro‐Diagnostik (Biosensorik), In‐vivo‐Diagnostik (Bioimaging) und Therapie.

show abstract

Electrochemical study of ivabradine hydrochloride ion selective electrodes using different ionophores

Abstract: Development of novel sensors for the determination of ivabradine hydrochloride using sulphonated calix-8-arene and cyclodextrin derivatives as neutral ionophores.

Cited by 7 publications

References 27 publications

Molecularly Imprinted Electrochemical Sensor-Based Fe2O3@MWCNTs for Ivabradine Drug Determination in Pharmaceutical Formulation, Serum, and Urine Samples

Molecularly Imprinted Electrochemical Sensor-Based Fe2O3@MWCNTs for Ivabradine Drug Determination in Pharmaceutical Formulation, Serum, and Urine Samples

Voltammetric Determination of Ivabradine Hydrochloride Using Multiwalled Carbon Nanotubes Modified Electrode in Presence of Sodium Dodecyl Sulfate

Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

Contact Info

Product

Resources

About