Electrochemical study of hydroxychloroquine and its determination in plaquenil by differential pulse voltammetry

Arguelho, Maria Lara P.M.; Andrade, José Fernando de; Stradiotto, Nelson Ramos

doi:10.1016/s0731-7085(02)00669-6

Cited by 57 publications

(21 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that the electrochemical behavior of this compound is dependent on pH and the electrodic process occurs through an ErCi mechanism possibly related to the cleavage of CÀ Cl bond, Figure 2. [107] In 2014, Asma Khoobi et al have described a nanosensor for the determination of HCQ in the presence of uric acid. [108] It is a glassy carbon electrode modified a novel Schiff base: N- […”

Section: Glassy Carbon-based Modified Electrodesmentioning

confidence: 99%

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

et al. 2020

View full text Add to dashboard Cite

Hydroxychloroquine (HCQ) is a drug indicated in rheumatology for the treatment of rheumatoid arthritis and systemic lupus erythematosus for its anti‐inflammatory and immunomodulatory properties. Many countries such as Morocco have recommended the use of HCQ for the treatment of COVID‐19 infection. This medication is responsible for severe acute poisoning. Therefore, Hospital laboratories have a fundamental role in affirming the diagnosis and assessing the severity of intoxication by measuring HCQ, carried out in the urine and preferably in whole blood. The analytical techniques used are essentially chromatographic. Unfortunately, these reference methods for forensic analyzes are difficult to adapt to emergency due to their delay in reporting results.

show abstract

Section: Glassy Carbon-based Modified Electrodesmentioning

confidence: 99%

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is very important to know the drug product release with respective the time in invitro conditions. The literature survey revealed different types of analytical techniques are used for determination of HCQ to report the information, such as HPLC with PDA detector [ 5 – 6 ], HPLC with UV detector [ 7 – 11 ], chromatography-tandem mass spectrometry [ 12 – 13 ], LC/IT/MS [ 14 ], capillary-LC [ 15 ], Electrochemical study [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel RP-HPLC-DAD Method Development for Anti-Malarial and COVID-19 Hydroxy Chloroquine Sulfate Tablets and Profiling of In-Vitro Dissolution in Multimedia.

Dongala

Ettaboina

Katari

2020

Preprint

View full text Add to dashboard Cite

Hydroxychloroquine sulfate is one of a large series of 4-aminoquinolines with antimalarial activity. Moreover, it is used for the treatment of rheumatoid arthritis. Sometimes Hydroxychloroquine sulfate is very effective for the treatment of autoimmune diseases. Based on the recent clinical experiments it is exploiting for the treatment of COVID-19, corona virus across the globe. A Reverse phase RP-HPLC method have been developed and validated as per the current ICH guidelines for estimation of Hydroxychloroquine sulfate tablets. As part of method validation specificity, linearity, precision and recovery parameters were verified. The concentration and area relationships were linear (R2 > 0.999), over the concentration range of 25 to 300 µg mL-1 for HCQ. The relative standard deviations for precision and intermediate precision were less than 1.5%. The proposed RP-HPLC generic method was applied successfully for evaluation of invitro dissolution profile with different pH conditions like 0.1N HCl, pH 4.5 Acetate buffer and pH 6.8 Phosphate buffers of US marketed reference product.

show abstract

“…The literature survey revealed different types of analytical techniques are used for determination of HCQ, such as HPLC with PDA detector [ 8 , 9 ], HPLC with UV detector [ 10 – 14 ], chromatography-tandem mass spectrometry [ 15 , 16 ], LC/IT/MS [ 17 ] and some other techniques [ 18 , 19 ]. The majority of the literature was reported in pharmacokinetics of HCQ in biological fluids.…”

Section: Introductionmentioning

confidence: 99%

Stability Indicating LC Method Development for Hydroxychloroquine Sulfate Impurities as Available for Treatment of COVID-19 and Evaluation of Risk Assessment Prior to Method Validation by Quality by Design Approach

Dongala

Katari

Palakurthi³

et al. 2020

Chromatographia

View full text Add to dashboard Cite

A quality by design-based stability indicating HPLC method has been developed for hydroxychloroquine sulfate impurities. The optimized HPLC method can detect and quantify the hydroxychloroquine sulfate and related organic impurities in pharmaceutical solid oral dosage forms. Nowadays, for the quantification of impurities in drug products demands more comprehensive way of analytical method development. The quality by design approach allows the assessment of different analytical parameters and their effects with minimum number of experiments. A highly sensitive and stability indicating RP-HPLC method was developed and evaluated the risk assessment prior to method validation. The chromatographic separation was achieved with X-terra phenyl column (250 × 4.6 mm, 5 µm) using phosphate buffer (0.3 M and pH 2.5). The gradient method flow rate was 1.5 mL min −1 and UV detection was made at 220 nm. The calibration curve of hydroxychloroquine sulfate and related impurities were linear from LOQ to 150% and correlation coefficient was found more than 0.999. The precision and intermediate precision % RSD values were found less than 2.0. In all forced degradation conditions, the purity angle of HCQ was found less than purity threshold. The optimized method found to be specific, accurate, rugged, and robust for determination of hydroxychloroquine sulfate impurities in the solid oral dosage forms. Finally, the method was applied successfully in quality control lab for stability analysis.

show abstract

Electrochemical study of hydroxychloroquine and its determination in plaquenil by differential pulse voltammetry

Cited by 57 publications

References 11 publications

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

Current Trends in Analytical Methods for the Determination of Hydroxychloroquine and Its Application as Treatment for COVID‐19

A Novel RP-HPLC-DAD Method Development for Anti-Malarial and COVID-19 Hydroxy Chloroquine Sulfate Tablets and Profiling of In-Vitro Dissolution in Multimedia.

Stability Indicating LC Method Development for Hydroxychloroquine Sulfate Impurities as Available for Treatment of COVID-19 and Evaluation of Risk Assessment Prior to Method Validation by Quality by Design Approach

Contact Info

Product

Resources

About