Electrochemical Sensors Based on Polymers Printed Molecularly and The Determination of Drugs in Pharmaceutical and Biological Samples

Abstract

Quality control of medicines is of extreme importance since its use is carried out on a large scale throughout the world, and any errors in its production directly affect the effectiveness of the same, as well as the people who use them. Therefore, the search for more sensitive, selective, lower cost and easy handling methods is essential for this control to be done efficiently. Among the techniques that present such characteristics, electroanalytical techniques stand out, especially with the use of modified sensors, both for determination and for quantification of drugs. One of the modifiers that see gaining space in this area are molecularly printed polymers (MIPs), which appear as a promising tool for the development of systems with biomimetic recognition, similar to specific systems (antigen-antibody). The advantages of MIPs relative to biological materials include easy and low cost preparation and simple storage, which often occurs at room temperature for long periods of time. Despite the diversity of work involving MIPs in the preparation of samples in general, their application as modifying agents in sensors for any analyte is still restricted. Thus, the present review aims to evaluate the application of modified MIP sensors for the determination of drugs in biological and pharmaceutical samples and the progress of this analytical methodology in the present time.