Electrochemical Sensors Based on Carbon Nanotubes

Zhao, Qiang; Gan, Zhenhai; Zhuang, Qiya

doi:10.1002/elan.200290000

Cited by 579 publications

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“…Many biological reactions, and the nervous system chemical processes can be considered as a type of organic electrochemical process. 1,2 Therefore, a study on the electrochemical behavior of Ep is a great help in understanding the effects of the nervous system and artificial substitutes, and is of great significance to pharmacological research and the life sciences. Determination of concentrations of Ep is important for the study of neurotransmission, for diagnosis of neurological disorders, such as Parkinson's, and for developing medicines to treat the diseases.…”

Section: Introductionmentioning

confidence: 99%

A sensitive simultaneous determination of epinephrine and tyrosine using an iron(III) doped zeolite-modified carbon paste electrode

Babaei¹,

Mirzakhani²,

Khalilzadeh³

2009

J. Braz. Chem. Soc.

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Um eletrodo de pasta de carbono modificado com zeólitas e dopado com ferro(III) foi usado como um sensor eletroquímico de alta sensibilidade e seletividade para a determinação simultânea de pequenas quantidades de compostos biologicamente importantes como epinefrina (Ep) e tirosina (Tyr). Os resultados da voltametria de pulso diferencial (DPV) usando este eletrodo modificado mostra duas ondas anódicas bem traçadas para a oxidação da Ep e da Tyr, as quais tornam possíveis a determinação simultanêa destes compostos. A faixa linear de 0,9 a 216 mmol L -1 para a Ep em uma concentração fixa de 30 mmol L -1 Tyr em solução tampão fosfato, pH 3,0 foi obtida das medidas de DPV usando este eletrodo, com um coeficiente de correlação de 0,9998 e limite de quantificação igual a 0,44 mmol L -1 . A linearidade obtida para a Tyr na presença de 30 mmol L -1 de Ep, foi de 1,2 a 90 mmol L -1 com um coeficiente de correlação de 0,9989 e limite de quantificação de 0,32 mmol L -1 . O eletrodo modificado apresentou uma boa reprodutibilidade (RSD< 2.5%), baixo limite de quantificação (sub-micromolar) e alta sensibilidade para a detecção de ambos Ep e Tyr com uma elevada estabilidade em sua resposta voltamétrica. O desempenho analítico deste sensor tem sido avaliado para a detecção de epinefrina e tirosina em soro humano e em amostras farmacêuticas com resultados satisfatórios.A Zeolite modified carbon paste electrode doped with iron(III) was used as a highly sensitive and selective electrochemical sensor for simultaneous determination of minor amounts of epinephrine (Ep) and tyrosine (Tyr) as the biologically important compounds. The results of differential pulse voltammetry (DPV) using this modified electrode show two well-resolved anodic waves for the oxidation of Ep and Tyr ,which makes it possible for simultaneous determination of both compounds. A linear range from 0.9 to 216 mmol L -1 for Ep at a constant concentration of 30 mmol L -1 Tyr in buffered solution (phosphate buffer, pH 3.0) was obtained from DPV measurement using this electrode with a correlation coefficient of 0.9998 and a detection limit of 0.44 mmol L -1 . The linear range, which is obtained for Tyr in the presence of 30 mmol L -1 Ep, was in the range from 1.2 to 90 µmol L -1 with a correlation coefficient of 0.9989 and a detection limit of 0.32 mmol L -1 . The modified electrode had good reproducibility (RSD < 2.5%), low detection limit (sub-micromolar) and high sensitivity for the detection of both Ep and Tyr with a very high stability in its voltammetric response. The analytical performance of this sensor has been evaluated for detection of Ep and Tyr in human serum and in a pharmaceutical sample with satisfactory results.Keywords: Epinephrine, tyrosine, Fe(III) doped zeolite, modified carbon paste electrode IntroductionEpinephrine (Ep), Scheme 1 (a), often called adrenaline, is one of the most important neurotransmitters in mammalian central nervous systems, existing in the nervous tissue and body fluid, and controlling the nervous system in the performance of ...

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Section: Introductionmentioning

confidence: 99%

A sensitive simultaneous determination of epinephrine and tyrosine using an iron(III) doped zeolite-modified carbon paste electrode

Babaei¹,

Mirzakhani²,

Khalilzadeh³

2009

J. Braz. Chem. Soc.

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“…MWCNTs are long, multi-walled, thin cylinders of carbon that can be described as several two-dimensional graphite sheets rolled into a tube [27]. Recent studies have shown the ability of MWCNTs to promote electron transfer reactions of both important biomolecules [28,29] and redox centers embedded deep within proteins [30,31]. This electrocatalytic property, as well as the chemical stability and high mechanical strength of MWCNTs, has rendered them an appealing material for use in biosensors [32].…”

Section: Introductionmentioning

confidence: 99%

A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber

Snider

Ciobanu

Rue

et al. 2008

Analytica Chimica Acta

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We have developed a multiwalled carbon nanotube/dihydropyran (MWCNT/DHP) composite sensor for the electrochemical detection of insulin in a microfluidic device. This sensor has been employed for physiological measurements of secreted insulin from pancreatic islets in a Cytosensor® previously modified to be a multianalyte microphysiometer (MAMP). When compared with other established electrochemical insulin sensors, the MWCNT/DHP composite film sensor presented improved resistance to fluidic shear forces, while achieving enhanced electrode kinetics. In addition, the preparation of the composite film is straightforward and facile with a self-polymerizing monomer, DHP, used to add mechanical stability to the film. The sensor film was able to detect insulin concentrations as low as 1 µM in the MAMP during calibration experiments. The MWCNT/DHP composite sensor has been successfully used for the direct detection of insulin secreted by islets in the microphysiometer.

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“…Because of their outstanding electrical properties such as high current densities, high electrical conductivity, and high sensitivity, they are certain to be spotlighted in future nanotechnology. Among their other attributes, single wall NTs (SWNTs) possess good sensitivity at room temperature, which offers great prospects in many future sensing applications [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

SWNT Sensors for Monitoring the Oxidation of Edible Oils

Lee¹,

Lee²,

Lau³

et al. 2013

Journal of Sensor Science and Technology

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Several methods are available to measure the oxidation of edible oils, such as their acid, peroxide, and anisidine values. However, these methods require large quantities of reagents and are time-consuming tasks. Therefore, a more convenient and time-saving way to measure the oxidation of edible oils is required. In this study, an edible oil-condition sensor was fabricated using single-walled nanotubes (SWNTs) made using the spray deposition method. SWNTs were dispersed in a dimethylformamide solution. The suspension was then sprayed using a spray gun onto a prefabricated Au/Ti electrode. To test the sensor, oxidized edible oils, each with a different acid value, were prepared. The SWNT sensors were immersed into these oxidized oils, and the resistance changes in the sensors were measured. We found that the conductivity of the sensors decreased as the oxidation level of the oil increased. In the case of the virgin oil, the resistance change ratio in the SWNT sensor S(%) = {[(Rf _ Ri)]/Ri}(%) was more than 40% after immersion for 1 min. However, in the case of the oxidized oil, the resistance change ratio decreased to less than that of the response of the virgin oil. This result suggests that the change in the oil components induced by the oxidation process in edible oils is related to the conductivity change in the SWNT sensor.Keywords : Single-walled carbon nanotubes, Edible oil oxidation, Acid value, Chemical sensor 1 Display and Nanosystem Laboratory, Korea University, Seoul, 136-713, Korea 2 SNSREVOLUTION Co., Ltd., Anam-dong, Seongbuk-gu, Seoul, Korea + Corresponding author: bkju@korea.ac.kr (Received : Apr. 22, 2013, Revise : Jun. 15, 2013, Accepted : Jul. 1, 2013 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/bync/3.0)which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Electrochemical Sensors Based on Carbon Nanotubes

Cited by 579 publications

References 36 publications

A sensitive simultaneous determination of epinephrine and tyrosine using an iron(III) doped zeolite-modified carbon paste electrode

A sensitive simultaneous determination of epinephrine and tyrosine using an iron(III) doped zeolite-modified carbon paste electrode

A multiwalled carbon nanotube/dihydropyran composite film electrode for insulin detection in a microphysiometer chamber

SWNT Sensors for Monitoring the Oxidation of Edible Oils

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