Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic‐Type Acids as Cross‐Linker for the Determination of Quinine

Abstract

A novel cross‐linker (functional abietic‐type acids) for preparing highly sensitive, molecularly imprinted sensors was proposed for quinine determination. A MIP film was created on a glassy carbon electrode for determination of quinine using free radical polymerization method. The modification procedure was characterized via electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The interaction between functional monomer and target molecule was observed by UV spectrometric methods. Under the optimal experimental conditions, the peak currents were proportional to the concentrations of quinine in the range from 8.0×10−7 to 2.6×10−4 M with a detection limit of 2.0×10−8 M. Meanwhile the prepared sensor showed sensitive and selective binding sites for quinine. Determination of quinine in tonic water showed good recovery.

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

“…LuPc2 modified electrode exhibited appreciable electrocatalytic activity in contrast to PrPc2 electrode, which does not give any response to Qn. 58 The prepared sensor showed sensitive and selective binding sites for Qn and was employed for Qn determination. The principal component analysis of the obtained signals confirmed the capability of the electrodes for discrimination towards the bitter solutions.…”

“…A molecularly imprinted polymer (MIP) lm with methacrylic acid (MAA) as functional monomer and ethylene glycol maleic rosinate acrylate (EGMRA) as cross-linker was created on GCE surface via free radical polymerization method. 58 The prepared sensor showed sensitive and selective binding sites for Qn and was employed for Qn determination. Though cinchonine, cinchonidine, caffeine and theophylline did not affect the amperometric response towards the drug, a signicant interference was observed in presence of tenfold of quinidine.…”

“…A MIP film was created on GCE surface using free radical polymerization method for determination of Qn 58. Similar to DNA, peptides can be synthesized and selected by automated routes in a combinatorial way, and hence, hold promise to function as effective recognition elements in electrochemical sensors for analysis of antimalarial drugs.…”

Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract

“…Quinine‐MIPs have been reported for the development of sensors for the detection of quinine 48,49 and chromatographic stationary phases for the chiral separation of quinine and quinidine 18 . However, researches seldom focused on their applications in separating cinchona alkaloids from natural products.…”

An electrochemical sensor based on molecularly imprinted membranes on a P-ATP–AuNP modified electrode for the determination of acrylamide

“…18,19 Although the number of binding sites increases with an increase in the imprinted membrane thickness, thick imprinted membranes can lead to the slow diffusion of analytes to recognition sites and inefficient communication between the imprinted sites and transducers. 20,21 The polymerization of conductive polymers or doping with metal nanoparticles is the most effective way to improve the conductivity of molecularly imprinted sensors. 22,23 The co-polymerization of gold nanoparticles (AuNPs) and conductive polymers from the composite membrane results in high conductivity, large specic surface area, and good biocompatibility.…”