Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers

Hernández-Rodríguez, Juan F.; Rojas, Daniel; Escarpa, Alberto

doi:10.1021/acs.analchem.0c04378

Cited by 77 publications

(46 citation statements)

References 175 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, patients have the possibility to test themselves and take necessary actions, such as self-isolation. 40 A clinical study was carried out to evaluate the accuracy and applicability of the system. The assay was applied to both a buffer solution and the blood serum samples collected from COVID-19 patients, compared to the clinically approved methods.…”

Section: Introductionmentioning

confidence: 99%

Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor

et al. 2021

View full text Add to dashboard Cite

The global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has revealed the urgent need for accurate, rapid, and affordable diagnostic tests for epidemic understanding and management by monitoring the population worldwide. Though current diagnostic methods including real-time polymerase chain reaction (RT-PCR) provide sensitive detection of SARS-CoV-2, they require relatively long processing time, equipped laboratory facilities, and highly skilled personnel. Laser-scribed graphene (LSG)-based biosensing platforms have gained enormous attention as miniaturized electrochemical systems, holding an enormous potential as point-of-care (POC) diagnostic tools. We describe here a miniaturized LSG-based electrochemical sensing scheme for coronavirus disease 2019 (COVID-19) diagnosis combined with three-dimensional (3D) gold nanostructures. This electrode was modified with the SARS-CoV-2 spike protein antibody following the proper surface modifications proved by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) characterizations as well as electrochemical techniques. The system was integrated into a handheld POC detection system operated using a custom smartphone application, providing a user-friendly diagnostic platform due to its ease of operation, accessibility, and systematic data management. The analytical features of the electrochemical immunoassay were evaluated using the standard solution of S-protein in the range of 5.0–500 ng/mL with a detection limit of 2.9 ng/mL. A clinical study was carried out on 23 patient blood serum samples with successful COVID-19 diagnosis, compared to the commercial RT-PCR, antibody blood test, and enzyme-linked immunosorbent assay (ELISA) IgG and IgA test results. Our test provides faster results compared to commercial diagnostic tools and offers a promising alternative solution for next-generation POC applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor

et al. 2021

View full text Add to dashboard Cite

show abstract

“…With advance in wearable technology, many wearable devices providing important body information like blood glucose concentration, blood oxygen level, blood pressure, and heart rhythms have been sold in the market. Electrochemical sensors are mostly found in the wearable devices, mainly because of their advantages of miniaturization, low cost, fast response, high sensitivity, and specificity (Hernández-Rodríguez et al, 2021). In addition, electrodes can be made on various substrates such as plastic, textile thread, glass, ceramic, or skin.…”

Section: Heath Monitoringmentioning

confidence: 99%

Grand Challenges in Analytical Science

Chang

2021

Front. Anal. Sci.

View full text Add to dashboard Cite

“…Electrochemical sensors have been effectively validated against laboratory standard methods proving their usefulness as pointof-care tests. [120,121] In contrast, when translated to WEDs, few works have validated the continuous analysis with standard methods. There are several reasons: (i) a method to analyze the noninvasive fluid needs to be standardized (e.g., sweat or ISF); (ii) a sampling method has to be designed and coupled with the standard method (e.g., regional sweat collection); and (iii) real-time analysis of the biofluid is challenging as the determination by the standard method cannot be performed in situ, thus several errors along the manipulation of the sample might rise inconsistent results.…”

Section: The Second Challenge: Validationmentioning

confidence: 99%

Wearable Self‐Powered Electrochemical Devices for Continuous Health Management

Parrilla

Wael

2021

Adv Funct Materials

View full text Add to dashboard Cite

The wearable revolution is already present in society through numerous gadgets. However, the contest remains in fully deployable wearable (bio) chemical sensing. Its use is constrained by the energy consumption which is provided by miniaturized batteries, limiting the autonomy of the device. Hence, the combination of materials and engineering efforts to develop sustainable energy management is paramount in the next generation of wearable self-powered electrochemical devices (WeSPEDs). In this direction, this review highlights for the first time the incorporation of innovative energy harvesting technologies with top-notch wearable self-powered sensors and low-powered electrochemical sensors toward battery-free and self-sustainable devices for health and wellbeing management. First, current elements such as wearable designs, electrochemical sensors, energy harvesters and storage, and user interfaces that conform WeSPEDs are depicted. Importantly, the bottlenecks in the development of WeSPEDs from an analytical perspective, product side, and power needs are carefully addressed. Subsequently, energy harvesting opportunities to power wearable electrochemical sensors are discussed. Finally, key findings that will enable the next generation of wearable devices are proposed. Overall, this review aims to bring new strategies for an energy-balanced deployment of WeSPEDs for successful monitoring of (bio) chemical parameters of the body toward personalized, predictive, and importantly, preventive healthcare.

show abstract

Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers

Cited by 77 publications

References 175 publications

Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor

Rapid Point-of-Care COVID-19 Diagnosis with a Gold-Nanoarchitecture-Assisted Laser-Scribed Graphene Biosensor

Grand Challenges in Analytical Science

Wearable Self‐Powered Electrochemical Devices for Continuous Health Management

Contact Info

Product

Resources

About