Electrochemical, quantum-chemical and antioxidant properties of antipyrine and its derivatives

Bashkatova, N.V.; Короткова, Е. И.; Karbainov, Yu. A.; Yagovkin, A. Yu.; Бакибаев, А. А.

doi:10.1016/j.jpba.2004.11.046

Cited by 49 publications

(19 citation statements)

References 5 publications

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“…In electrochemical functions, APDs also exhibit some significant properties. Bashkatova et al [13] have reported the electrochemical and antioxidant properties of antipyrine and its derivatives; Abd El Rehim et al [14] have investigated on the antiputrefactive effect of 4-(2 0 -amino-5 0 -methylphenylazo)antipyrine using weight loss and potentiodynamic polarization; El-Sayed et al [15] have studied on the correlation of the molecular structure with the current-voltage and temperature dependence of the electrical conductivity of 4-(2-hydroxy-4-methyphenylazo)antipyrine. In optoelectronic materials, APDs have exhibited promising optical characteristics [16,17], and they are hopeful to be further investigated as new type nonlinear optical optoelectronic materials according to the NLO materials structural characteristics.…”

Section: Introductionmentioning

confidence: 99%

Experimental and density functional studies on 4-(3,4-dihydroxybenzylideneamino)antipyrine, and 4-(2,3,4-trihydroxybenzylideneamino)antipyrine

Sun

Hao

Wei

et al. 2009

Journal of Molecular Structure: THEOCHEM

318

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Section: Introductionmentioning

confidence: 99%

Experimental and density functional studies on 4-(3,4-dihydroxybenzylideneamino)antipyrine, and 4-(2,3,4-trihydroxybenzylideneamino)antipyrine

Sun

Hao

Wei

et al. 2009

Journal of Molecular Structure: THEOCHEM

318

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“…It is worth to mention that there are studies demonstrating that this adverse effect might be exaggerated . Several congeners and transition metal complexes of antipyrine were also biological evaluated , being reported with antivirus and antibacterial activity .…”

Section: Introductionmentioning

confidence: 99%

Novel 4‐Heteroaryl‐antipyrines: Synthesis, Molecular Docking, and Evaluation as Potential Anti‐breast Cancer Agents

Tao

Gomha

Badrey

et al. 2018

Journal of Heterocyclic Chem

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Reaction of 1‐[4‐(1,2‐dihydro‐1,5‐dimethyl‐2‐phenyl‐3‐oxo‐3H‐pyrazol‐4‐yl)‐2‐phenylsulfonyl‐1‐ethanone (1) with phenyl isothiocyanate afforded the 4‐(3‐mercapto‐3‐(phenylamino)‐2‐(phenylsulfonyl)acryloyl)‐1,5‐dimethyl‐2‐phenyl‐1H‐pyrazol‐3(2H)‐one (2). Treatment of compound 2 with hydrazonoyl chlorides 3a–h afforded the corresponding1,3,4‐thiadiazole derivatives 5a–h. Cyclocondensation reaction of compound 2 with the appropriate α‐halo‐compounds 6, 8, 10, 12a,b or 14 (ethyl 2‐chloroacetate, chloroacetonitrile, 1‐chloropropan‐2‐one, 2‐bromo‐1‐phenylethanone, 2‐bromo‐1‐p‐tolylethanone, and 2‐bromoacetyl‐3H‐benzo [f]chromen‐3‐one) afforded the 1,3‐thiazole derivatives 7, 9, 11, 13a,b, and 15, respectively. Coupling of the ketosulphone 1 with the appropriate diazotized 4H‐1,2,4‐triazol‐3‐amine 16 and 2‐aminobenzimidazole 19 afforded triazolo[5,1‐c][1, 2, 4]triazine 18 and benzo[4,5]imidazo[2,1‐c][1, 2, 4]triazine 21, respectively. The structures of the synthesized compounds were confirmed on the basis of their elemental analysis and spectral data and evaluated as potential anti‐breast cancer agents. Moreover, the computational studies using MOE 2014.09 software are confirming the results in biological activity.

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“…Antipyrine (1‐phenyl‐2,3‐dimethylpyrazol‐5‐one) 1 and its derivatives play an important role in heterocyclic synthesis as they are of great biological and medicinal value . They are important pyrazolone derivatives and have been widely used for a long time in medicine as antipyretic , analgesic , sedative , antimicrobial , antiviral , antioxidant , anticancer , and anti‐inflammatory drugs . They have been also widely used to study the influence of age, disease, drugs, and hereditary and environmental factors on drug metabolism .…”

Section: Introductionmentioning

confidence: 99%

Synthetic Routes to Selected Heterocycles Containing Antipyrine Moiety

El‐Taweel

Elmaaty

2015

Journal of Heterocyclic Chem

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This review deals with the synthetic potentiality and utility of antipyrine and its derivatives in the synthesis of 4-substituted antipyrine and other heterocycles containing antipyrine moiety such as thiazole, pyrazolopyridines, pyrazolopyrimidines, and pyrazolotriazines. The reactions that cover the methods of synthesizing the aforementioned heterocycles such as addition, condensation, and cyclization were also reviewed.

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Electrochemical, quantum-chemical and antioxidant properties of antipyrine and its derivatives

Cited by 49 publications

References 5 publications

Experimental and density functional studies on 4-(3,4-dihydroxybenzylideneamino)antipyrine, and 4-(2,3,4-trihydroxybenzylideneamino)antipyrine

Experimental and density functional studies on 4-(3,4-dihydroxybenzylideneamino)antipyrine, and 4-(2,3,4-trihydroxybenzylideneamino)antipyrine

Novel 4‐Heteroaryl‐antipyrines: Synthesis, Molecular Docking, and Evaluation as Potential Anti‐breast Cancer Agents

Synthetic Routes to Selected Heterocycles Containing Antipyrine Moiety

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