Electrochemical Oxidation of Aminophylline at Film Platinum Electrodes, and its Determination in Cosmetic and Pharmaceutical Products

Wang, Lai-Hao; Wang, Chia-Chen

doi:10.1007/s00604-005-0455-z

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…The modified K 2 PtCl 6 /CPE electrode was produced by a previous method. 23 The carbon paste (graphite powder: paraffin oil: …”

Section: Construction Of a Flow-through Voltammetric Detectormentioning

confidence: 99%

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Use of a Disposable Modified Carbon Paste Electrode for Liquid Chromatography‐amperometric Detection of Theophylline and Three Metabolites in Human Serum

Wang¹,

Tien²,

Tai³

2006

J Chinese Chemical Soc

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Chemically modified electrodes, constructed by incorporating potassium hexachloroplatinate K 2 PtCl 6 into the graphite power/paraffin oil matrix used to fabricate conventional carbon paste electrodes, were shown to catalyze the electrooxidation of purine compounds including theophylline, 3-methylxanthine, 1,3-dimethyluric acid and 1-methyluric acid; the modifier electrodes display electrocatalytic activity for the oxidation of purines at 170 mV (vs Ag/AgCl) when used as sensing electrodes in amperometric detection following liquid chromatography. The K 2 PtCl 6 electrodes permitted detection of the purines at similar values of applied potential. The limit of detection (LOD) of theophylline, 1-MUA, 3-MXT and 1,3-DMUA were 1.1 ng mL -1 , 3.2 ng mL -1 , 1.0 ng mL -1 and 11 ng mL -1 , respectively. The calibration graphs were linear for theophylline and metabolites over the range of concentration used (50-3200 ng mL -1 ). Theophylline and its metabolites can easily be separated and analyzed in one run using electrochemical sensor chromatography with a methanol -phosphate buffer containing 20 mM di-potassium hydrogen phosphate (pH 5.50). Serum samples were collected after the oral administration of black tea from human volunteers. Quantitative data for the determination of a micromolar amount of theophylline and its metabolites in serum samples are in agreement with data obtained by HPLC-UV.

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“…The modified K 2 PtCl 6 /CPE electrode was produced by a previous method. 23 The carbon paste (graphite powder: paraffin oil: …”

Section: Construction Of a Flow-through Voltammetric Detectormentioning

confidence: 99%

“…The modified K 2 PtCl 6 /CPE electrode was produced by a previous method. 23 The carbon paste (graphite powder: paraffin oil: K 2 PtC1 6 (4:1:0.1 w/w) was inserted into one end of the Teflon tube (1/32 in. i.d., 1/16 in.…”

Section: Construction Of a Flow-through Voltammetric Detectormentioning

confidence: 99%

Use of a Disposable Modified Carbon Paste Electrode for Liquid Chromatography‐amperometric Detection of Theophylline and Three Metabolites in Human Serum

Wang¹,

Tien²,

Tai³

2006

J Chinese Chemical Soc

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“…Aminophylline (AMP, C 16 H 24 N 10 O 4 , Figure 1) is a bronchodilator compound composed of the theophylline with ethylenediamine added (ratio of 2:1) to increase bioavailability, and is given to treat respiratory diseases including asthma, panting bronchitis, and cardiogenic asthma (Gelvez et al, 2004;Shiohira, Fujii, Koizumi, Kondoh, & Watanabe, 2009). AMP is also used as an ingredient of skin cream products but can allergic reactions due to the ethylenediamine component (Wang & Wang, 2006). AMP quickly releases theophylline in buffer solutions (pH 7.4) and blood samples, and when the dose is greater than 20 µg/mL, it can occasionally produce serious toxicity issues, including nausea, emesis, and central nervous system excitation (Kesavan & John, 2014;Peng, Wang, Xiao, Wang, & Ding, 2016).…”

Section: Introductionmentioning

confidence: 99%

Detection of aminophylline in serum using an immunochromatographic strip test

Suryoprabowo

Kuang

et al. 2019

Food and Agricultural Immunology

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Aminophylline (AMP), a bronchodilator drug, is a modified form of theophylline (the pharmacological active ingredient). AMP is often given to treat respiratory diseases, including bronchial asthma, blocked emphysema, panting bronchitis, and cardiogenic asthma. In this study, we developed a rapid and sensitive method to determine AMP concentration in mouse serum. A sensitive monoclonal antibody against AMP was produced by immunizing BALB/c mice with a well-characterized AMP2-keyhole limpet hemocyanin and coating antigen (hapten-AMP1-OVA). The coating antigen and goat anti-mouse IgG antibody were sprayed onto a nitrocellulose membrane representing the test and control lines, respectively. Under optimized conditions, the cut-off limits of the test strip were 50 ng/mL in 0.01 M phosphate buffered saline (pH 7.4) and 250 ng/mL in serum. The results were obtained within 10 min and revealed that this immunochromatographic strip test is a sensitive, rapid, and simple tool for the detection of AMP in serum.

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“…In general, they are high performance liquid chromatography, 8 spectroscopy, 9 chemiluminescence, 10 LC/MS 11 and electrochemical detection. [12][13][14] However, not all of these methods are suitable for the rapid detection of clinical blood aminophylline concentration. For example, the HPLC or LC/MS method needs complicated pretreatment and is time-consuming, which is not appropriate for rapid clinical determination.…”

Section: Introductionmentioning

confidence: 99%

“…20,21 The result indicates that the disposable SPE could achieve therapeutic drug monitoring by electrochemical methods. Based on reported articles, 6,7,12,13 aminophylline or theophylline could be detected by electrochemical methods. Therefore, we supposed that the SPE could detect the blood aminophylline concentration for clinical therapeutic drug monitoring.…”

Section: Introductionmentioning

confidence: 99%

Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO₂/Au composite modified screen-printed electrode

et al. 2016

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Electrochemical Oxidation of Aminophylline at Film Platinum Electrodes, and its Determination in Cosmetic and Pharmaceutical Products

Cited by 11 publications

References 30 publications

Use of a Disposable Modified Carbon Paste Electrode for Liquid Chromatography‐amperometric Detection of Theophylline and Three Metabolites in Human Serum

Use of a Disposable Modified Carbon Paste Electrode for Liquid Chromatography‐amperometric Detection of Theophylline and Three Metabolites in Human Serum

Detection of aminophylline in serum using an immunochromatographic strip test

Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO₂/Au composite modified screen-printed electrode

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Electrochemical Oxidation of Aminophylline at Film Platinum Electrodes, and its Determination in Cosmetic and Pharmaceutical Products

Cited by 11 publications

References 30 publications

Use of a Disposable Modified Carbon Paste Electrode for Liquid Chromatography‐amperometric Detection of Theophylline and Three Metabolites in Human Serum

Use of a Disposable Modified Carbon Paste Electrode for Liquid Chromatography‐amperometric Detection of Theophylline and Three Metabolites in Human Serum

Detection of aminophylline in serum using an immunochromatographic strip test

Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO2/Au composite modified screen-printed electrode

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Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO₂/Au composite modified screen-printed electrode