Electrochemical methods in conjunction with capillary and microchip electrophoresis

Mark, Jonas Josef Peter; Scholz, Rebekka; Matysik, Frank‐Michael

doi:10.1016/j.chroma.2012.07.009

Cited by 59 publications

(33 citation statements)

References 191 publications

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“…In general, fabrication of electrodes through classic photolithography techniques allows direct integration into microfluidic devices. Electrochemistry coupled to microchip electrophoresis has been previously reviewed [121-124]. …”

Section: Detection Strategiesmentioning

confidence: 99%

A review of microdialysis coupled to microchip electrophoresis for monitoring biological events

Saylor

Lunte

2015

Journal of Chromatography A

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Microdialysis is a powerful sampling technique that enables monitoring of dynamic processes in vitro and in vivo. The combination of microdialysis with chromatographic or electrophoretic methods yields along with selective detection methods yields a “separation-based sensor” capable of monitoring multiple analytes in near real time. Analysis of microdialysis samples requires techniques that are fast (<1 min), have low volume requirements (nL–pL), and, ideally, can be employed on-line. Microchip electrophoresis fulfills these requirements and also permits the possibility of integrating sample preparation and manipulation with detection strategies directly on-chip. Microdialysis coupled to microchip electrophoresis has been employed for monitoring biological events in vivo and in vitro. This review discusses technical considerations for coupling microdialysis sampling and microchip electrophoresis, including various interface designs, and current applications in the field.

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Section: Detection Strategiesmentioning

confidence: 99%

A review of microdialysis coupled to microchip electrophoresis for monitoring biological events

Saylor

Lunte

2015

Journal of Chromatography A

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“…Other detection schemes, such as contact or contacless capacitively coupled conductivity detection, electrochemical, (electro)chemiluminescence, infrared spectroscopy, and NMR, are less suitable and much less utilized to peptide detection in CE and CEC than UV absorption, fluorescence, and MS detectors. For that reason, only some recent reviews are cited here, which are dealing with general developments and applications of these detectors, such as electrochemical , conductivity , chemiluminescence , electrochemiluminescence , mid‐infrared , and NMR , where few applications of these detectors for CE separation of peptides as model analytes could be mentioned.…”

Section: Detectionmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2011–2013)

Kašička

2013

Electrophoresis

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The review presents a comprehensive survey of recent developments and applications of capillary and microchip electroseparation methods (zone electrophoresis, ITP, IEF, affinity electrophoresis, EKC, and electrochromatography) for analysis, isolation, purification, and physicochemical and biochemical characterization of peptides. Advances in the investigation of electromigration properties of peptides, in the methodology of their analysis, including sample preseparation, preconcentration and derivatization, adsorption suppression and EOF control, as well as in detection of peptides, are presented. New developments in particular CE and CEC modes are reported and several types of their applications to peptide analysis are described: conventional qualitative and quantitative analysis, determination in complex (bio)matrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid, sequence and chiral analysis, and peptide mapping of proteins. Some micropreparative peptide separations are shown and capabilities of CE and CEC techniques to provide relevant physicochemical characteristics of peptides are demonstrated.

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“…C 4 D has gained overwhelming popularity in recent years, being increasingly implemented both in capillary and microchip separation formats. As follows from a substantial fraction of available general literature , C 4 D drove out of common use other electrochemical detection techniques and significantly replaced conventional UV detection. A further iconic review on the developments and applications of CE with C 4 D, coauthored by Pavel Kubáň and Hauser , reveals that the method has been seeing a healthy growth, with an increasing number of reports based on using commercial detectors.…”

Section: Reviewsmentioning

confidence: 99%

“…Perhaps it is this tendency that allowed Mai and Hauser to conclude that the C 4 D has reached a degree of maturity so that new fundamental understandings or radical instrumental improvements are not very likely to occur. According to Matysik and coworkers , progress in C 4 D electronics and technology of detection cells is still perceptible. Both teams agree though that the development of low‐cost, portable devices for point‐of‐care analysis continues to attract considerable research interest.…”

Section: Reviewsmentioning

confidence: 99%

Inorganic analysis using CE: Advanced methodologies to face old challenges

Kubáň

Timerbaev

2013

Electrophoresis

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Inorganic species still remain of secondary importance when CE is used as an analytical separation tool. Despite considerable efforts of great many groups over last 20 years, plenty of competition, mostly from ion chromatography and elemental MS, restrains the routine use of CE in inorganic analysis. If there is yet hope clinging to make CE a viable alternative in the field, success would ultimately be attained through research activities on negating the disadvantages and amplifying the advantages of the method. Being the latest update of a series of reviews covering the time period from 1990 to 2010, this paper will comment on how and to what extent these challenges of inorganic CE analysis have been addressed in two recent years.

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Electrochemical methods in conjunction with capillary and microchip electrophoresis

Cited by 59 publications

References 191 publications

A review of microdialysis coupled to microchip electrophoresis for monitoring biological events

A review of microdialysis coupled to microchip electrophoresis for monitoring biological events

Recent developments in capillary and microchip electroseparations of peptides (2011–2013)

Inorganic analysis using CE: Advanced methodologies to face old challenges

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