Electrochemical Immunosensors for Antibiotic Detection

Pollap, Aleksandra; Kochana, Jolanta

doi:10.3390/bios9020061

Cited by 96 publications

(48 citation statements)

References 97 publications

(154 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A bioreceptor is used to recognize the target antigen or antibody that converts the producing biological signal into the desired signal by a transducer. It is an effective technique for the detection of pathogens because antibodies are naturally bound with antigens to form an antigen-antibody complex which is the main principle of immunosensor for detecting antibody or antigen ( Pollap and Kochana, 2019 ). Four types of immunosensor can be categorized according to the transducer, e.g., electrochemical, thermometric, optical and magnetic ( Patris et al, 2016 ).…”

Section: Electrochemical Biosensors For Virus Detectionmentioning

confidence: 99%

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Khan¹,

Hasan

Hossain

et al. 2020

Biosensors and Bioelectronics

164

108

View full text Add to dashboard Cite

Last few decades, viruses are a real menace to human safety. Therefore, the rapid identification of viruses should be one of the best ways to prevent an outbreak and important implications for medical healthcare. The recent outbreak of coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus which belongs to the single-stranded, positive-strand RNA viruses. The pandemic dimension spread of COVID-19 poses a severe threat to the health and lives of seven billion people worldwide. There is a growing urgency worldwide to establish a point-of-care device for the rapid detection of COVID-19 to prevent subsequent secondary spread. Therefore, the need for sensitive, selective, and rapid diagnostic devices plays a vital role in selecting appropriate treatments and to prevent the epidemics. During the last decade, electrochemical biosensors have emerged as reliable analytical devices and represent a new promising tool for the detection of different pathogenic viruses. This review summarizes the state of the art of different virus detection with currently available electrochemical detection methods. Moreover, this review discusses different fabrication techniques, detection principles, and applications of various virus biosensors. Future research also looks at the use of electrochemical biosensors regarding a potential detection kit for the rapid identification of the COVID-19.

show abstract

Section: Electrochemical Biosensors For Virus Detectionmentioning

confidence: 99%

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Khan¹,

Hasan

Hossain

et al. 2020

Biosensors and Bioelectronics

164

108

View full text Add to dashboard Cite

show abstract

“…Furthermore, the detection of antibiotic drugs from different groups based on the electrochemical Immunosensor was demonstrated in the review article by Pollap and Kochana in detail [47].…”

Section: Immunoassaysmentioning

confidence: 99%

Determination and Identification of Antibiotic Drugs and Bacterial Strains in Biological Samples

2020

View full text Add to dashboard Cite

Antibiotics were initially natural substances. However, nowadays, they also include synthetic drugs, which show their activity against bacteria, killing or inhibiting their growth and division. Thanks to these properties, many antibiotics have quickly found practical application in the fight against infectious diseases such as tuberculosis, syphilis, gastrointestinal infections, pneumonia, bronchitis, meningitis and septicemia. Antibiotic resistance is currently a detrimental problem; therefore, in addition to the improvement of antibiotic therapy, attention should also be paid to active metabolites in the body, which may play an important role in exacerbating the existing problem. Taking into account the clinical, cognitive and diagnostic purposes of drug monitoring, it is important to select an appropriate analytical method that meets all the requirements. The detection and identification of the microorganism responsible for the infection is also an essential factor in the implementation of appropriate antibiotic therapy. In recent years, clinical microbiology laboratories have experienced revolutionary changes in the way microorganisms are identified. The MALDI-TOF MS technique may be interesting, especially in some areas where a quick analysis is required, as is the case with clinical microbiology. This method is not targeted, which means that no prior knowledge of the infectious agent is required, since identification is based on a database match.

show abstract

“…As a compact analytical device, an immunosensor presents a surface where antigen-antibody complex can be detected and also converted into electrical and biomechanical signals using transducers. The final detected signals can then the processed, recorded, and displayed [74]. The advantages of these immunosensors in comparison to traditional PAH detection methods like gas chromatography-mass spectrometry (GC-MS) are several, including miniaturization of instrumental devices.…”

Section: Immunosensorsmentioning

confidence: 99%

“…The basis in of this type of transduction is the response of a surface upon variations in the stress and loading applied to it. Velocity and position can be used in detecting measurement performance [74,84]. In addition, piezoelectric materials (where mechanical stress generates an accumulation of electric charge) such as quartz crystals have been used to immobilize antibodies and antigens [76,81].…”

Section: Mechanicalmentioning

confidence: 99%

Future Trends for In Situ Monitoring of Polycyclic Aromatic Hydrocarbons in Water Sources: The Role of Immunosensing Techniques

2019

View full text Add to dashboard Cite

Polycyclic aromatic hydrocarbons (PAHs) are hazardous environmental pollutants found in water, soil, and air. Exposure to this family of chemicals presents a danger to human health, and as a result, it is imperative to design methods that are able to detect PAHs in the environment, thus improving the quality of drinking water and agricultural soils. This review presents emerging immunoassay techniques used for in situ detection of PAH in water samples and how they compare to common-place techniques. It will discuss their advantages and disadvantages and why it is required to find new solutions to analyze water samples. These techniques are effective in reducing detection times and complexity of measurements. Immunoassay methods presented here are able to provide in situ analysis of PAH concentrations in a water sample, which can be a great complement to existing laboratory techniques due to their real-time screening and portability for immunoassay techniques. The discussion shows in detail the most relevant state-of-the-art surface functionalization techniques used in the field of immunosensors, with the aim to improve PAH detection capabilities. Specifically, three surface functionalization techniques are key approaches to improve the detection of PAHs, namely, substrate surface reaction, layer-by-layer technique, and redox-active probes. These techniques have shown promising improvements in the detection of PAHs in water samples, since they show a wider linear range and high level of sensitivity compared to traditional PAH detection techniques. This review explores the various methods used in the detection of PAH in water environments. It provides extra knowledge to scientists on the possible solutions that can be used to save time and resources. The combination of the solutions presented here shows great promise in the development of portable solutions that will be able to analyze a sample in a matter of minutes on the field.

show abstract

Electrochemical Immunosensors for Antibiotic Detection

Cited by 96 publications

References 97 publications

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Ultrasensitive detection of pathogenic viruses with electrochemical biosensor: State of the art

Determination and Identification of Antibiotic Drugs and Bacterial Strains in Biological Samples

Future Trends for In Situ Monitoring of Polycyclic Aromatic Hydrocarbons in Water Sources: The Role of Immunosensing Techniques

Contact Info

Product

Resources

About