Electrochemical dissolution of biomedical grade Ti6Al4V: Influence of stress and environment

Chandra, Abhijit; Ryu, J.J.; Karra, Pavan; Shrotriya, Pranav; Weik, Thomas

doi:10.1016/j.cirp.2009.03.114

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…Thus, to avoid an early deterioration of the prothesis, it would be necessary to adapt the NMES program to the type of implanted materials. As previously reported, it should be noticed that repetitive mechanical stress could influence implant wear and loosening …”

Section: Discussionsupporting

confidence: 52%

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Biocompatibility of four common orthopedic biomaterials following neuroelectromyostimulation: Anin‐vivostudy

et al. 2017

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Despite the worldwide high prevalence of total joint arthroplasty (TJA), life expectancy of prosthesis remains limited by mechanical and chemical constraint which promote wear debris production, surrounding tissues damage and finally prosthesis loosening. Such results could be amplified by neuro-myoelectrostimulation (NMES; widely used to reduce neuromuscular deficits observed following TJA surgery). It was previously described in an in vivo experiment that interactions between NMES and Ti6Al4V implant are deleterious for both implant and surrounding muscles. The purpose of the present study was to compare the biocompatibility of four common orthopedic biomaterials, two metallic (Ti6Al4V, CrCo) and two nonmetallic (PEEK, Al O ) alloys, fixed on rat tibial crest in which the surrounding muscles were electrostimulated. Muscle cell death rate was not found significantly increased, with or without electrical stimulation for nonmetallic implants. Contrary to Ti6Al4V alloy, the CrCo implant did not induce destruction of the surrounding muscle. However, cell viability decreased for both metallic alloys when NMES was applied but within a greater significant extent for Ti6Al4V implant. Otherwise, when NMES was applied, implant-to-bone adhesion significantly decreased for Ti6Al4V while no significant difference was found for PEEK, Al O , and CrCo. Statistical analyses reveal also a lesser adhesion strength for Ti6Al4V compared with CrCo when NMES was applied. Selecting the most suitable material in term of biocompatibility remains a major concern and non-metallic materials seems to be more appropriated in regard to electrical currents used for post TJA care. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1156-1164, 2018.

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Section: Discussionsupporting

confidence: 52%

“…As previously reported, it should be noticed that repetitive mechanical stress could influence implant wear and loosening. 3,68,69…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of four common orthopedic biomaterials following neuroelectromyostimulation: Anin‐vivostudy

et al. 2017

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“…The surface damage during contact loading is due to the synergistic interactions of contact loading induced abrasions and chemical reactions associated with repassivation and material dissolution [55,64,65]. In dry and passivating environments, the surface damage is primarily due to the cyclic process of abrasion of metal surface and repassivation of the exposed surfaces.…”

Section: Resultsmentioning

confidence: 99%

Mechanical load assisted dissolution response of biomedical cobalt–chromium and titanium metallic alloys: Influence of in-plane stress and chemical environment

Ryu

Shrotriya

2015

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a b s t r a c tMechanical load-assisted dissolution is identified as one of the key mechanisms governing material removal in fretting and crevice corrosion of biomedical implants. In the current study, material removal on a stressed surface of cobalt-chromium-molybdenum (CoCr) and titanium (Ti-64) alloys subjected to single asperity contact is investigated in order to identify the influence of contact loads and in-plane stress state on surface damage mechanisms. The experiments were conducted in ambient as well as three different aqueous environments -phosphate buffered saline (PBS) at pH 7.4, PBS at pH 4.1 and high chloride solutions at pH 4.0. The tip of an atomic force microscope is used as a well-characterized "asperity" to apply controlled contact forces and mechanically stimulate the loaded specimen surface in different aqueous environments from passivating to corroding. The volume of the material removed is measured to determine the influence of contact loads, in-plane stresses and the environment on the material dissolution rate. Experimental results indicate that surface damage is initiated at all the contact loads studied and as expected in a wear situation, removal rate increases with increase in contact loads. For both alloys, removal rates display a complex dependence on residual stresses and the environment. In a passivating environment, the material removal rate is linearly dependent on the stress state such that surface damage is accelerated under compressive stresses and suppressed under tensile stresses. In a corrosive environment, the dissolution rate demonstrates a quadratic dependence on stress, with both compressive and tensile stresses accelerating material dissolution. The material removal rates are found to be consistently larger for CoCr in comparison to Ti64 surfaces under the same mechanical and electrochemical stimuli, despite the higher hardness of CoCr surfaces.

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“…Additionally, this process could induce the formation of metallic debris originating from the prosthesis and could generate an electrochemical dissolution stress . Interactions between metallic prostheses and biological tissues lead to the formation of corrosion‐induced debris enhancing the risk of aseptic loosening . As previously reported, titanium debris weakens the anchorage of an implant placed in the rat tibial crest .…”

Section: Introductionmentioning

confidence: 86%

Titanium implant impairment and surrounding muscle cell death following neuro‐myoelectrostimulation: An in vivo study

et al. 2014

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Electrical currents have deleterious effects on biomedical metallic implants. However, following arthroplasty, neuro-myoelectrostimulation (NMES) is often used in patient rehabilitation. Such a rehabilitation technique could compromise patient recovery through deleterious effects on metallic alloys and biological tissues. The purpose of our study was to assess the effects of NMES on a Ti6Al4V implant placed in a rat tibial crest and the surrounding muscle tissues. This in vivo study allowed to bring to the fore the prosthesis behavior under mechanical and electromagnetic loads induced by NEMS stimulation. After 3 weeks, implant-to-bone adhesion significantly decreased in stimulated animals compared with nonstimulated animals. Surface mapping indicated titanium implant degradation after NMES. Furthermore, NMES alone did not induce muscle damage contrary to that found in implanted animals. The muscle damage rate was significantly higher in implanted and stimulated animals compared with implanted-only animals. It seems obvious that rehabilitation programs using the NMES technique could induce early deterioration of biomaterial employed for surgical implants. Clinicians should reconsider the use of NMES as a rehabilitation technique for patients with titanium prostheses.

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Electrochemical dissolution of biomedical grade Ti6Al4V: Influence of stress and environment

Cited by 11 publications

References 10 publications

Biocompatibility of four common orthopedic biomaterials following neuroelectromyostimulation: Anin‐vivostudy

Biocompatibility of four common orthopedic biomaterials following neuroelectromyostimulation: Anin‐vivostudy

Mechanical load assisted dissolution response of biomedical cobalt–chromium and titanium metallic alloys: Influence of in-plane stress and chemical environment

Titanium implant impairment and surrounding muscle cell death following neuro‐myoelectrostimulation: An in vivo study

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