Electrochemical determination of N-acetyl cysteine in the presence of acetaminophen at multi-walled carbon nanotubes and nafion modified sensor

Savan, Ebru Kuyumcu

doi:10.1016/j.snb.2018.11.092

Cited by 34 publications

(2 citation statements)

References 21 publications

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“…In this way, the studied potential decreases and the reaction rate of many electroactive substances increases. Thus, carbon nanotube modified electrodes show better electrochemical performance than other conventional carbon electrodes (Kuyumcu Savan, 2019a, 2019bPalisoc et al, 2019). The electrochemical properties of both carbon nanotube and conductive polymers provide the modified electrode to have new and unique properties.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

Savan

Erdoğdu

2021

International Journal of Pure and Applied Sciences

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In this study, it was aimed to use pyrrole monomer and single-walled carbon nanotube (SWCNT) in the production of modified electrodes, and to examine the electrochemical properties of these electrodes. Bulk electrolysis technique was used for growing polypyrrole. The applicability of the polypyrrole and SWCNT-based electrodes was tested by electrochemically detecting active substances such as levodopa (LD) and benserazide (BS) used in the treatment of Parkinson's disease. During the design and analysis phase of the modified electrode, many electroanalytical optimization and validation parameters were examined. The developed modified electrode gave linear responses with DPV technique in concentration ranges of 10 -50 µM for LD and 10 -50 µM for BS. In addition, limits of detection in these wide linear ranges were obtained as very low. Limits of detection were calculated as 2.4 µM and 1.2 µM for LD and BS, respectively. In addition, the applicability of the designed electrode and method was tested in urine and drug samples. The selectivity of this electrode was carried out in placebo solutions containing the interfering species. It is advantageous that the drug active ingredients are easily, selectively and quickly determined at this modified electrode in the presence of components that affect the analysis. Eventually, very satisfactory results in terms of analytical performance and applicability have been achieved with the designed electrode.

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Section: Introductionmentioning

confidence: 99%

Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

Savan

Erdoğdu

2021

International Journal of Pure and Applied Sciences

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“…The PFSA membranes modified with CNTs are hybrid materials with a mixed electron-ionic conductivity and high sorption ability [ 56 , 57 ]. The use of such materials in voltammetric sensors provides a simultaneous increase in the sensitivity and selectivity, as well as a reduction in the exposure to fouling [ 58 , 59 ]. The modification of the CNTs’ surface by hydrophilic groups allows us to decrease their aggregation in the PFSA polymer dispersion and affects their distribution between the hydrophilic and hydrophobic membrane phases.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

et al. 2023

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The degradation of drugs is a substantial problem since it affects the safety and effectiveness of pharmaceutical products, as well as their influence on the environment. A novel system of three potentiometric cross-sensitive sensors (using the Donnan potential (DP) as an analytical signal) and a reference electrode was developed for the analysis of UV-degraded sulfacetamide drugs. The membranes for DP-sensors were prepared by a casting procedure from a dispersion of perfluorosulfonic acid (PFSA) polymer, containing carbon nanotubes (CNTs), whose surface was preliminarily modified with carboxyl, sulfonic acid, or (3-aminopropyl)trimethoxysilanol groups. A correlation between the sorption and transport properties of the hybrid membranes and cross-sensitivity of the DP-sensor to sulfacetamide, its degradation product, and inorganic ions was revealed. The analysis of the UV-degraded sulfacetamide drugs using the multisensory system based on hybrid membranes with optimized properties did not require a pre-separation of the components. The limits of detection of sulfacetamide, sulfanilamide, and sodium were 1.8 × 10−7, 5.8 × 10−7, and 1.8 × 10−7 M. The relative errors of the determination of the components of the UV-degraded sulfacetamide drugs were 2–3% (at 6–8% relative standard deviation). PFSA/CNT hybrid materials provided the stable work of the sensors for at least one year.

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Exploitation of carbon surface functionality toward additive‐free formation of gold nanocuboids suitable for sensitive assay of N‐acetylcysteine in pharmaceutical formulations

Murphy,

Guin,

Lapiy

et al. 2024

Electrochemical Science Adv

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Chemical additive and physical template‐free electrochemical methods to prepare carbon‐supported nanostructures of catalyst metals represent an emerging technology. Formation of the metal nano/microstructures depends not only on the electrochemical method/parameters but also on the nature of the underlying carbon material. Here, we present a comparative evolution of unevenly distributed coral‐like aggregates of nanocuboid‐shaped gold nanostructures (AuNCBs) on the oxidised form of boron, nitrogen‐doped carbon nanoonions (oxi‐B,N‐CNO) compared to evenly distributed bud‐like aggregates of cubic shaped gold nanostructures on bare glassy carbon electrode under a similar electrochemical approach. The synthesis method provided the best availability of the surface active sites, whereas the shape of the structures showed a direct influence of both outer‐sphere and inner‐sphere electron transfer reactions. The higher sensitivity of AuNCBs@oxi‐B,N‐CNO compared to individual components and bare carbon/gold electrodes toward the inner‐sphere oxidative reaction of N‐acetyl‐L‐cysteine (NAC) was exploited in order to develop an electrochemical assay method with sensitivity and linear dynamic range of (4.70 ± 0.25) × 10−4 C∙cm−2∙mM−1 and 0.2–2.5 mM, respectively in acetate buffer (pH 4.45). Furthermore, the sensor design was deployed in the quantitation of NAC in pharmaceutical preparations, resulting in 89%–106% recovery.

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Electrochemical determination of N-acetyl cysteine in the presence of acetaminophen at multi-walled carbon nanotubes and nafion modified sensor

Cited by 34 publications

References 21 publications

Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

Voltammetric Detection of Levodopa and Benserazide at Polypyrrole and Single Walled Carbon Nanotube Based Electrode

Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

Exploitation of carbon surface functionality toward additive‐free formation of gold nanocuboids suitable for sensitive assay of N‐acetylcysteine in pharmaceutical formulations

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