Electrochemical determination of gatifloxacin, moxifloxacin and sparfloxacin fluoroquinolonic antibiotics on glassy carbon electrode in pharmaceutical formulations

Radi, Abd-Elgawad; Wahdan, Tarek; Anwar, Zeinab M.; Mostafa, Hend

doi:10.1002/dta.143

Cited by 30 publications

(25 citation statements)

References 29 publications

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“…The bactericidal action of Moxi results from trapping of enzymes on DNA and lethal release of doublestranded breaks, thereby inhibiting of cell replication [3]. Various analytical methods have been cited in literature for Moxi determinations including spectrophotometry, spectrofluorimetry, atomic absorption spectrometry, conductometry, voltammetry [4][5][6][7][8][9][10], high performance liquid chromatography-ultraviolet (HPLC-UV), HPLC-fluorescence(HPLC-Fl), capillary electrophoresis(CE), and HPLC-mass spectrometry (HPLC-MS) [4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

Idress¹,

Elbashir²,

Nur³

2017

Pharm Anal Acta

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Potentiometric determination of moxifloxacin (Moxi) by ion selective electrode based on ZnO nanorods incorporation with HPβ-CD as sensing ionophore and (KTFPB) potassium tetrakis-(3,5(triflouromethyl) phenyl borate ion as anionic site (additive) in polyvinyl chloride (PVC) membrane, without inner reference solution was developed. The sensor shows nearly nernstian response over a concentration range ( 5 × 10 -8 M to 1 × 10 -2 M) with a slope of 21.9 ± 0.16 mv decade -1 of concentration with a limit of detection (LOD) 0.127 μM. The electrode exhibits a fast dynamic response of 2 s for a period of 6 months without significant change in its characteristics with excellent stability and sensitivity toward inorganic species. The method is accurate and precise as indicated by the mean recoveries 99.5% with RSD less than 2%. The proposed method was successfully applied for the determination of Moxi in pure form and its pharmaceutical formulations.

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Section: Introductionmentioning

confidence: 99%

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

Idress¹,

Elbashir²,

Nur³

2017

Pharm Anal Acta

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“…Various methods cited in literature for its determinations involve, spectrophotometry [4,5], spectrofluorimetry [6], atomic absorption spectrometry [7], conductometry [7], voltammetry [8], high performance liquid chromatography- ultraviolet (HPLC-UV) [9-11], HPLC-fluorescence (HPLC-Fl) [12-14] capillary electrophoresis (CE) [15,16], and HPLC-mass spectrometry (HPLC-MS) [17,18]. However, most of these methods involve time-consuming procedures, derivatization and/ or sophisticated instruments.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors

Hefnawy

Homoda

Abounassif

et al. 2014

Chemistry Central Journal

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BackgroundThe construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials.ResultsThe sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10−2 - 4.0 × 10−6, 1 × 10−2 - 5.0 × 10−6, 1 × 10−2 - 5.0 × 10−6 M), with detection limits of 3 × 10−6, 4 × 10−6 and 4.0 × 10−6 M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively.ConclusionsThe proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.

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“…Several methods have been reported for the determination of fluoroquinolones either in pure forms, dosage forms, or biological fluids like chromatography [5–9], microchip electrophoresis [10], chiral counter-current chromatography [11], capillary zone electrophoresis [12], electrochemistry [13–15], atomic absorption spectrometry [16, 17], and spectrofluorimetry [18–21]. However, these methods are expensive and not available at most quality control laboratories.…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin Hydrochloride, and Enrofloxacin in Pharmaceutical Formulations Using Acid Dyes

Gouda

Amin

El-Sheikh

et al. 2014

Journal of Analytical Methods in Chemistry

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Simple, rapid, and extractive spectrophotometric methods were developed for the determination of some fluoroquinolones antibiotics: gemifloxacin mesylate (GMF), moxifloxacin hydrochloride (MXF), and enrofloxacin (ENF) in pure forms and pharmaceutical formulations. These methods are based on the formation of ion-pair complexes between the basic drugs and acid dyes, namely, bromocresol green (BCG), bromocresol purple (BCP), bromophenol blue (BPB), bromothymol blue (BTB), and methyl orange (MO) in acidic buffer solutions. The formed complexes were extracted with chloroform and measured at 420, 408, 416, 415, and 422 nm for BCG, BCP, BPB, BTB, and MO, respectively, for GMF; at 410, 415, 416, and 420 nm for BCP, BTB, BPB, and MO, respectively, for MXF; and at 419 and 414 nm for BCG and BTB, respectively, in case of ENF. The analytical parameters and their effects are investigated. Beer's law was obeyed in the ranges 1.0–30, 1.0–20, and 2.0–24 μg mL−1 for GMF, MXF, and ENF, respectively. The proposed methods have been applied successfully for the analysis of the studied drugs in pure forms and pharmaceutical formulations. Statistical comparison of the results with the reference methods showed excellent agreement and indicated no significant difference in accuracy and precision.

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Electrochemical determination of gatifloxacin, moxifloxacin and sparfloxacin fluoroquinolonic antibiotics on glassy carbon electrode in pharmaceutical formulations

Cited by 30 publications

References 29 publications

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

Potentiometric Determination of Moxifloxacin by ZnO Nanorodes Modified ion Selective Electrode

Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors

Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin Hydrochloride, and Enrofloxacin in Pharmaceutical Formulations Using Acid Dyes

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