Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors

Abstract

BackgroundThe construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials.ResultsThe sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10−2 - 4.0 × 10−6, 1 × 10−2 - 5.0 × 10−6, 1 × 10−2 - 5.0 × 10−6 M), with detection limits of 3 × 10−6, 4 × 10−6 and 4.0 × 10−6 M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively.ConclusionsThe proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.

Crystal structure of N-(2-(2-oxoindolin-4-yl)ethyl)-N-propylpropan-1-aminium tetraphenylborate, C40H45BN2O

“…Sodium tetraphenylborate is used in inorganic and organometallic chemistry as a precipitating reagent [6]. It is also used for the formation of sensing material in polyvinyl chloride sensors [7][8][9][10].…”

Crystal structure of 1-(3-chloropropyl)piperidin-1-ium tetraphenylborate, C32H37BClN

“…Sodium tetraphenylborate is a popular precipitating reagent [5]. It is also used as association for construct of sensing material used in chemical sensors [6][7][8][9]. The title compound crystallizes with one cation N-(3-chloropropyl) piperidinum ion and anion tetraphenylborate in the asymmetric unit (cf.…”

Tetraphenylborate Salt of Bambuterol (Bambec®): Synthesis, Characterization and X-ray Structure of N-(2-(3,5-bis((dimethylcarbamoyl)oxy)phenyl)-2-hydroxyethyl)-2-methylpropan-2-aminium tetraphenylborate

“…Furthermore, tetraphenylborate recently was used as a precipitating agent for radioactive ion extraction [4]. It is also used as precipitating agent for formation of new active materials which were used as ion sensing material for some drug [5][6][7][8][9].…”