Electrochemical determination of fumonisin B1 using a chemosensor with a recognition unit comprising molecularly imprinted polymer nanoparticles

Aptamer-Based Detection of Fumonisin B1: A Systematic Comparison with Conventional and Other Novel Methods

“…Despite the fact that the use of antibodies with electrochemical readouts was advantageous for achieving some of the lowest LODs for fumonisin B1, equivalent to 4.6e-7 and 3.7e-6 µg/L [101,109], these immunosensors were not included in the principal component analysis (PCA), as no assay time was reported in either case. Hence, as indicated in Figure 5, LC-MS [56,75], immunoassays with optical [99,107,135], Raman (due to its quick procedure) [140], fluorescent readouts [147] and electrochemical MIPs [191] were correlated to the combination of low LODs with short assay times. However, such statistical analysis did not show the advantages of aptamer-based methods, which was also observed on the correlation of short assay preparation times with LC-MS, immunologic and only three aptasensors [159,167,200].…”

“…Nevertheless, some sensors qualified as fast required overnight steps and long incubation times for the whole system arrangement, especially when the synthesis of nanoparticles and drying phases were required. Assay times below ten minutes were achieved through chromatographic, immunoassays, and some innovative methods, nonetheless the more sensitive assays were secured with aptamer-based biosensors [170,177,200], immunosensors with carbon nanotubes [101,109], and molecularly imprinted polymer nanoparticles (MIPs) [191], as indicated in Figures 4a and 4c.…”

“…In a similar approach, an iridium tin oxide (ITO) electrode modified with CdS quantum dots, chitosan (undefined characteristics) and graphene oxide worked as the UV polymerization area, in which the resulting MIPs were used for photoelectrochemical evaluation of FB1 levels as low as 4.7 ng/L [144]. The application of nanoMIPs in electrochemical measurements (EIS, DPV) allowed the achievement of LODs as low as 21.6 fg/L, which so far is the lowest value reported for FB1 [191]. On the other hand, capillary electrophoresis (CE) was initially reported in 1995 as a different technique with greater capability for the separation of FB1 to that from LC, where either its integration with MS detection or the quantification of fluorescent derivatives were utilized in the analysis of corn [192,193].…”

Electrochemical Biosensors in Food Safety: Challenges and Perspectives

“…Hence, this electrochemical immunosensing approach can be employed for a rapid detection of different mycotoxins present at the same in food. As a more recent example, we would like to introduce a sensitive and selective electrochemical sensor using molecularly imprinted polymer nanoparticles (nanoMIPs) for FB1 recognition [77]. It is an electrochemical sensor, not properly a biosensor, but the detection strategy is very interesting and effective.…”

Determination of sitagliptin in human plasma using a smart electrochemical sensor based on electroactive molecularly imprinted nanoparticles

“…Molecularly imprinted polymers (MIP) were employed successfully as biomimetic receptors in sensors for range of different targets [39][40][41] . These artificial receptors selectively bind the target analyte and give high sensitive response when immobilized on electrochemical detectors [42][43][44][45] . Nevertheless, there is still a plenty of room for improvement of device integration and fabrication.…”