Electrochemical determination of dopamine using a conductive polypyrrole/carbon-coated mesoporous silica composite electrode

Liu, Yu-Che; Hsu, Wei-Fang; Wu, Tzong‐Ming

doi:10.1007/s10800-019-01391-2

Cited by 11 publications

(4 citation statements)

References 40 publications

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“…The current response of the obtained 12-bilayer PABA/PSS film was obviously higher than that of bare FTO. It implied that the electro-oxidation current response of the modified electrode was due to the PANi derivative could catalyze the DA oxidation, and also exhibited the electron transfer kinetics for the DA redox [ 24 , 56 ]. At the surface of PABA/PSS electrode, with PABA as the last layer, as shown in Figure 8 a, the improvement of electrocatalytic activity could be probably due to the π–π interaction of the phenyl structures of DA and electroactive PABA [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…The common conducting polymers for electrochemical biosensors are polyaniline (PANi) [ 20 ], polypyrrole (PPy) [ 21 ], poly(3,4-ethylenedioxythiophene) (PEDOT) [ 22 ] and polythiophene (PTH) [ 23 ]. The electrochemical sensor based on PPy/carbon-coated mesoporous silica (PPy/C#SiO 2 ) nanocomposite-modified glassy carbon electrodes (GCEs) demonstrated highly specific DA detection in the presence of the interference species [ 24 ]. In addition, PEDOT/PANi-modified GCEs was successfully prepared for simultaneous determination of DA, uric acid (UA) and ascorbic acid (AA) [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

2021

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Dopamine (DA) is an important neurotransmitter which indicates the risk of several neurological diseases. The selective determination with low detection limit is necessary for early diagnosis and prevention of neurological diseases associated with abnormal concentration of DA. The purpose of this study is to fabricate a poly(3-aminobenzylamine)/poly(sodium 4-styrenesulfonate) (PABA/PSS) multilayer thin film for use as an electrochemical DA biosensor. The PABA was firstly synthesized using a chemical oxidation method of 3-aminobenzylamine (ABA) monomer with ammonium persulfate (APS) as an oxidant. For electrochemical biosensor, the PABA/PSS thin film was fabricated on fluorine doped tin oxide (FTO)-coated glass substrate using the layer-by-layer (LBL) self-assembly method. The optimized number of bilayers was achieved using SEM and cyclic voltammetry (CV) results. The electroactivity of the optimized LBL thin film toward detection of DA in neutral solution was studied by CV and amperometry. The PABA/PSS thin film showed good sensitivity for DA sensing with sensitivity of 6.922 nA.cm−2.µM−1 and linear range of 0.1–1.0 µM (R2 = 0.9934), with low detection limit of 0.0628 µM, long-term stability and good reproducibility. In addition, the selectivity of the PABA/PSS thin film for detection of DA under the common interferences (i.e., ascorbic acid, uric acid and glucose) was also presented. The prepared PABA/PSS thin film showed the powerful efficiency for future use as DA biosensor in real sample analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

2021

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“…PPy/C#SiO 2 nanocomposite was synthesized using a mixture of pyrrole and previous manufactured carbon-coated mesoporous SiO 2 composite (C#SiO 2 ) [ 91 ]. The deposition of PPy was confirmed using WAXD and FTIR.…”

Section: Electrochemical Sensors Based On Conducting Polymersmentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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Electrochemical sensors appear as low-cost, rapid, easy to use, and in situ devices for determination of diverse analytes in a liquid solution. In that context, conducting polymers are much-explored sensor building materials because of their semiconductivity, structural versatility, multiple synthetic pathways, and stability in environmental conditions. In this state-of-the-art review, synthetic processes, morphological characterization, and nanostructure formation are analyzed for relevant literature about electrochemical sensors based on conducting polymers for the determination of molecules that (i) have a fundamental role in the human body function regulation, and (ii) are considered as water emergent pollutants. Special focus is put on the different types of micro- and nanostructures generated for the polymer itself or the combination with different materials in a composite, and how the rough morphology of the conducting polymers based electrochemical sensors affect their limit of detection. Polypyrroles, polyanilines, and polythiophenes appear as the most recurrent conducting polymers for the construction of electrochemical sensors. These conducting polymers are usually built starting from bifunctional precursor monomers resulting in linear and branched polymer structures; however, opportunities for sensitivity enhancement in electrochemical sensors have been recently reported by using conjugated microporous polymers synthesized from multifunctional monomers.

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“…A core for the in situ chemical-oxidative polymerization of conductive polypyrrole was used by carbon-coated mesoporous SiO 2 nanoparticles. The modified nanocomposites showed large peak currents for the DA oxidation reaction, revealing a very small charge-transfer resistance, suggesting that the electrochemical performance of the nanocomposites was enhanced [123].…”

Section: Nanoparticlesmentioning

confidence: 99%

Technological advances in electrochemical biosensors for the detection of disease biomarkers

et al. 2021

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With an increasing focus on health in contemporary society, interest in the diagnosis, treatment, and prevention of diseases has grown rapidly. Accordingly, the demand for biosensors for the early diagnosis of disease is increasing. However, the measurement range of existing electrochemical sensors is relatively high, which is not suitable for early disease diagnosis, requiring the detection of small amounts of biocomponents. Various attempts have been made to overcome this and amplify the signal, including binding with various labeling molecules, such as DNA, enzymes, nanoparticles, and carbon materials. Efforts are also being made to increase the sensitivity of electrochemical sensors, and the combination of nanomaterials, materials, and biotechnology offers the potential to increase sensitivity in a variety of ways. Recent studies suggest that electrochemical sensors can be a powerful tool in providing comprehensive insights into the targeting and detection of disease-associated biomarkers. Significant advances in nanomaterial and biomolecule approaches for improved sensitivity have resulted in the development of electrochemical biosensors capable of detecting multiple biomarkers in real time in clinically relevant samples. In this review, we have discussed the recent studies on electrochemical sensors for detection of diseases such as diabetes, degenerative diseases, and cancer. Further, we have highlighted new technologies to improve sensitivity using various materials, including DNA, enzymes, nanoparticles, and carbon materials.

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Electrochemical determination of dopamine using a conductive polypyrrole/carbon-coated mesoporous silica composite electrode

Cited by 11 publications

References 40 publications

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

Electrochemical Dopamine Biosensor Based on Poly(3-aminobenzylamine) Layer-by-Layer Self-Assembled Multilayer Thin Film

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

Technological advances in electrochemical biosensors for the detection of disease biomarkers

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