Electrochemical Determination of Diclofenac Sodium in Aqueous Solution on Cu‐Doped Zeolite‐Expanded Graphite‐Epoxy Electrode

Abstract

The electrochemical oxidation and determination of diclofenac sodium (DCF) at Cu-doped zeolite-modified expanded graphite-epoxy composite (CuZEGE) electrode was evaluated for a new alternative of quantitative determination of sodium diclofenac in aqueous solutions. Cyclic voltammetry was used to characterize the electrochemical behaviour of the electrode in the presence of diclofenac sodium in a 0.1 M NaOH supporting electrolyte. This modified electrode exhibited electrocatalytic effect towards sodium diclofenac oxidation, allowing its determination in aqueous solution. The linear dependence of the current versus diclofenac concentration was obtained using cyclic voltammetry, chronoamperometry, differential-pulsed voltammetry. The limit of detection for DCF reached by direct analysis on CuZEGE is from 2 10 À5 to 3 10 À7 M in relation with used technique and the potential value. Substantial enhancement of the electroanalytical parameters, e.g. the limit of detection of 5 10 À8 M. for the determination of DCF at CuZEGE electrode was reached by applying a chemical preconcentration step prior to voltammetric quantification.

Gold nanoparticle/multi-walled carbon nanotube modified glassy carbon electrode as a sensitive voltammetric sensor for the determination of diclofenac sodium

“…In view of the prominence of DS in clinical applications, various efforts have been made for the determination of DS, including gas chromatography-mass spectrometry [19,20], liquid chromatography [21][22][23], liquid chromatography-tandem mass spectrometry [24], spectrophotometry [25][26][27][28][29], colorimetry [30], spectrofluorimetry [31], and voltammetry [32][33][34][35][36][37][38][39][40][41][42][43] in biological fluids.…”

Flow‐Injection Amperometric Method for Determination of Diclofenac in Pharmaceutical Formulations Using a Boron‐Doped Diamond Electrode

“…Several methods for the determination of DCF have been reported in the literature, such as high performance liquid chromatography (HPLC) with electrochemical or UV detection [5][6][7], spectrophotometry [8,9], spectrofluorometry [10,11], gas chromatography [12], capillary zone electrophoresis [13,14], and electrochemistry [15,3,[16][17][18][19][20][21]. In all electrochemical methods, modified electrodes were used due to the gradual passivation or contamination of unmodified solid working electrodes occurred during the DCF oxidation (adsorption of the electrochemically generated product).…”

Electrochemical Selective and Simultaneous Detection of Diclofenac and Ibuprofen in Aqueous Solution Using HKUST-1 Metal-Organic Framework-Carbon Nanofiber Composite Electrode

“…The procedure for the preparation of HKUST-CNF-epoxy composite electrode is similar to the one applied for the carbon nanofiber-epoxy composite electrode, which was already published elsewhere [8,22]. …”

“…In the past decades, the voltammetric and amperometric techniques have been used to quantitatively determine pharmaceuticals [6,7,8,9,10]. Taking into account that the key of the efficient electrochemical detection method is represented by the electrode material, various types of solid [11] and carbon-based [12] electrodes have been reported for the determination of pharmaceuticals.…”