Electrochemical determination of antihypertensive drugs by employing costless and portable unmodified screen-printed electrodes

Khorshed, Ahmed A.; Khairy, Mohamed; Banks, Craig E.

doi:10.1016/j.talanta.2019.01.117

Cited by 33 publications

(13 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, drug analysis is of the greatest concern in analytical chemistry, especially in the pharmaceutical industry since it can help to select the dosage form by studying the stability of the active compound and to identify the impurities in pharmaceutical formulations [ 1 ]. However, analytical determinations of these compounds not only apply to the drugs manufacturing process but also to forensic science and for quantification of prohibited substances in doping [ 2 ] or drug abuse issues [ 3 ]. In addition, the growing demand for these compounds [ 4 ], together with the misuse that the population makes of them, cause wide pollution of waters and soils [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of an RP-HPLC-PDA Method for Determination of Paracetamol, Caffeine and Tramadol Hydrochloride in Pharmaceutical Formulations

et al. 2021

View full text Add to dashboard Cite

Paracetamol (acetaminophen) (PAR), caffeine (CAF) and tramadol hydrochloride (TRA) are important drugs widely used for many clinical purposes. Determination of their contents is of the paramount interest. In this respect, a quick, simple and sensitive isocratic RP-HPLC method with photodiode array detection was developed for the determination of paracetamol, caffeine and tramadol in pharmaceutical formulations. An improved sensitive procedure was also evolved for tramadol using a fluorescence detector system. A C18 column and a mobile phase constituted by methanol/phosphate were used. LODs were found to be 0.2 μg/mL, 0.1 μg/mL and 0.3 μg/mL for paracetamol, caffeine and tramadol hydrochloride, respectively, using photodiode-array detection. Alternatively, LOD for tramadol decreased to 0.1 μg/mL with the fluorescence detector. Other notable analytical figures of merit include the linear concentration ranges, 0.8–270 μg/mL, 0.4–250 μg/mL and 1.0–300 (0.2–40) μg/mL, for the same ordered analytes (including the fluorescence detector). The proposed method was successfully applied for the quantitative determination of the three drugs in tablet dosage forms.

show abstract

Section: Introductionmentioning

confidence: 99%

Development and Validation of an RP-HPLC-PDA Method for Determination of Paracetamol, Caffeine and Tramadol Hydrochloride in Pharmaceutical Formulations

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Surfactants also have protective effect against surface‐fouling and electro catalytic effect [17]. Especially the surfactant molecules are used to enhance the applicability of unmodified/bare glassy carbon electrode (GCE) in electrochemical methods [18].…”

Section: Introductionmentioning

confidence: 99%

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

et al. 2021

View full text Add to dashboard Cite

In this study, a differential pulse voltammetry method was designed for the simultaneous determination of etodolac and thiocolchicoside in a tablet dosage form. This method is a sensitive, costless and reproducible one initially designed for the simultaneous determination of etodolac and thiocolchicoside using bare/unmodified glassy carbon electrode in the presence of sodium dodecyl sulfate. At optimized conditions, the method showed linear responses with etodolac and thiocolchicoside concentration in the range of 1 μM to 80 μM. The limits of detection and quantification were calculated as 0.11 μM and 0.38 μM for etodolac and 0.20 μM and 0.67 μM for thiocolchicoside, respectively.

show abstract

“…The most important part of each voltammetric system is the working electrode (WE). For propranolol determination, different types of solid electrodes were used, e.g., glassy carbon electrode (GCE) [13,14], graphite electrode (GE) [15,16], carbon paste electrode (CPE) [17,18], boron doped diamond electrode (BDDE) [19], and screen printed electrode (SPE) [20,21]. A recent trend in electrochemical methods has focused on the modification of solid electrodes (GCE, CPE, GE, and SPE) in order to improve their performance.…”

Section: Introductionmentioning

confidence: 99%

A Novel Voltametric Measurements of Beta Blocker Drug Propranolol on Glassy Carbon Electrode Modified with Carbon Black Nanoparticles

et al. 2021

View full text Add to dashboard Cite

A new voltametric method for highly sensitive propranolol (PROP) determination was developed. A glassy carbon electrode modified with a hybrid material made of carbon black (CB) and Nafion was used as the working electrode. The preconcentration potential and time were optimized (550 mV and 15 s), as well as the supporting electrolyte (0.1 mol L−1 H2SO4). For 15 s preconcentration time, linearity was achieved in the range 0.5–3.5 μmol L−1 and for 120 s in 0.02–0.14 μmol L−1. Based on the conducted calibration (120 s preconcentration time) limit of detection (LOD) was calculated and was equal to 7 nmol L−1. To verify the usefulness of the developed method, propranolol determination was carried out in real samples (tablets and freeze-dried urine). Recoveries were calculated and were in the range 92–102%, suggesting that the method might be considered as accurate. The repeatability of the signal expressed as relative standard deviation (RSD) was equal to 1.5% (n = 9, PROP concentration 2.5 µmol L−1). The obtained results proved that the developed method for propranolol determination might be successfully applied in routine laboratory practice.

show abstract

Electrochemical determination of antihypertensive drugs by employing costless and portable unmodified screen-printed electrodes

Cited by 33 publications

References 66 publications

Development and Validation of an RP-HPLC-PDA Method for Determination of Paracetamol, Caffeine and Tramadol Hydrochloride in Pharmaceutical Formulations

Development and Validation of an RP-HPLC-PDA Method for Determination of Paracetamol, Caffeine and Tramadol Hydrochloride in Pharmaceutical Formulations

Electroanalytical Investigation and Simultaneous Determination of Etodolac and Thiocolchicoside at a Non‐modified Glassy Carbon Electrode in Anionic Surfactant Media

A Novel Voltametric Measurements of Beta Blocker Drug Propranolol on Glassy Carbon Electrode Modified with Carbon Black Nanoparticles

Contact Info

Product

Resources

About