Electrochemical determination of 2,6-diisopropylphenol after high-performance liquid chromatography of extracts from serum

Eubel, R.A.; Wium, Cherylynn Angela; Hawtrey, A. O.; Coetzee, J. F.

doi:10.1016/s0378-4347(00)82513-x

Cited by 16 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The measurement of blood concentration of propofol was performed according to previously described methods [14]. For the measurement of propofol, acetnitrile and internal standard were added to a plasma sample and vortexed for 1 min.…”

Section: Methodsmentioning

confidence: 99%

Propofol Sedation for Endoscopic Procedures in Patients 90 Years of Age and Older

Horiuchi¹,

Nakayama

Tanaka³

et al. 2008

Digestion

View full text Add to dashboard Cite

Background and Aim: There are only a few studies on propofol sedation for very elderly patients. The present study was undertaken to evaluate the safety of propofol sedation in patients 90 years of age and older undergoing endoscopic procedures. Methods: We prospectively assessed endoscopic procedures for patients 90 years of age and older using propofol sedation. Endoscopic procedures, dosage used, respiratory depression, complications and 30-day mortality were evaluated. In a subset of the enrolled patients, the blood concentrations of propofol were measured. Results: All 241 patients completed endoscopic procedures. For esophagogastroduodenoscopy, percutaneous endoscopic gastrostomy, colonoscopy, and endoscopic retrograde cholangiopancreatography, the mean propofol doses used were 22, 24, 46 and 42 mg, respectively. Four patients required oxygen and 1 patient was treated by short periods of mask ventilation. There was no perforation, bleeding, pancreatitis or 30-day mortality. In diagnostic esophagogastroduodenoscopy, the level of sedation and propofol blood concentrations after administration of propofol (24 ± 6.8 mg) in patients 90 years of age and older corresponded to those of propofol (61 ± 13 mg) in middle-aged patients (control). Conclusion: Low-dose propofol sedation is safe and may be enough for patients 90 years of age and older undergoing endoscopic procedures.

show abstract

Section: Methodsmentioning

confidence: 99%

Propofol Sedation for Endoscopic Procedures in Patients 90 Years of Age and Older

Horiuchi¹,

Nakayama

Tanaka³

et al. 2008

Digestion

View full text Add to dashboard Cite

show abstract

“…The measurement of blood concentration of propofol was performed according to previously described methods [14, 15]. For the measurement of propofol, acetnitrile and internal standard added to a plasma sample and vortexed for 1 min.…”

Section: Methodsmentioning

confidence: 99%

Safety and Driving Ability following Low-Dose Propofol Sedation

Horiuchi¹,

Nakayama

Katsuyama

et al. 2008

Digestion

View full text Add to dashboard Cite

Background and Aim: Automobile driving is prohibited after midazolam sedation because of the slow recovery of psychomotor function. This study prospectively assessed the safety of low-dose propofol sedation (study 1) and compared driving ability following propofol and midazolam sedation (study 2). Methods: Study 1: We prospectively investigated bolus injection of a low-dose of propofol (40–80 mg for <70 years and 30 mg for ≥70 years) for diagnostic esophagogastroduodenoscopy (EGD). Respiratory depression, time to full recovery, and overall patient satisfaction were evaluated and blood concentrations of propofol were measured. Study 2: A subset of subjects undergoing diagnostic EGD were randomized to receive 40 mg of propofol (n = 30), 4 mg of midazolam (n = 30) or no sedation controls (n = 20), and the residual effects of each drug were tested using a driving simulator. The primary outcome measure was driving ability. The second outcome measures were overall patient satisfaction and complications. Results: Study 1: Only 1.1% of 12,031 healthy subjects developed transient oxygen desaturation. Full recovery was present in 97.5% 30 min after the procedure; 99.8% were willing to repeat the same procedure. The blood levels of propofol (40–80 mg) at 60 min were <100 ng/ml. Study 2: Driving ability recovered to the basal level within 60 min of propofol administration but not with 120 min with midazolam. There were no complications; overall patient satisfaction was similar between propofol and midazolam (8.9 vs. 8.5, p = 0.34). Conclusion: Low-dose propofol sedation was safe and recovery including driving ability was with 60 min.

show abstract

“…SPE with HLB cartridges compares favorably with previous methods of sample preparation. Liquid-liquid extraction of propofol, which is described in most previous reports [12][13][14][15][16], extracted many unrelated compounds along with propofol thus increasing the background for the detector. Reports describing SPE of propofol from plasma [6,8] utilized SPE by a reversed phase C18 cartridge, which has two disadvantages: (1) the overall recovery may be as low as 72% [8], and (2) reproducibility is variable, particularly if the cartridge runs dry during extraction.…”

Section: Recovery Of Propofolmentioning

confidence: 99%

“…Sample preparation prior to analysis by HPLC or GC requires either liquid-liquid or solid-phase extraction (SPE). Liquid-liquid extraction with various solvents, although frequently used [12][13][14][15][16], is tedious and time-consuming. Some methods show good recovery of propofol, but their sensitivity is constrained by interfering constituents of plasma.…”

Section: Introductionmentioning

confidence: 99%

A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection

Bajpai

Varshney

Seubert

et al. 2004

Journal of Chromatography B

View full text Add to dashboard Cite

Electrochemical determination of 2,6-diisopropylphenol after high-performance liquid chromatography of extracts from serum

Cited by 16 publications

References 3 publications

Propofol Sedation for Endoscopic Procedures in Patients 90 Years of Age and Older

Propofol Sedation for Endoscopic Procedures in Patients 90 Years of Age and Older

Safety and Driving Ability following Low-Dose Propofol Sedation

A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry detection

Contact Info

Product

Resources

About