Electrochemical Detection of Serotonin Using t-ZrO₂ Nanoparticles Modified Carbon Paste Electrode

Abstract

Synthesis of zirconium oxide (zirconia) (ZrO2) nanoparticles (ZNPs) through gel combustion technique as well as their structural and morphological characterization using XRD, SEM and TEM forms the central theme of this work. Along with structural and morphological characterization, an electrochemical detection of Serotonin (5-HT) is described using ZNPs Modified Carbon Paste Electrode (ZMCPE). The XRD results confirms that particles are well crystallized in tetragonal phase with average particle size of 35 nm. From SEM it can be observed that, the materials formed is porous in nature and the particles are seems to be uniform in size. HRTEM reveals that, the particles size in the order of 30–40 nm and the crystallinity was supported by SAED pattern of the ZNPs and these results are in close agreement with the results obtained through XRD. The Electrochemical detection of Serotonin (5-HT) was performed through cyclic voltammetric and differential pulse voltammetric method at different circumstances like concentration of the analyte, applied potentials and pH of the medium. The DPV experiments shows that ZMCPE displays high sensitivity for the quantification of serotonin (5-HT) in the range 10–50 μM and the limit of detection is 0.585 μM. The ZMCPE gives good reproducibility, high catalytic activity and sensitivity for the electrochemical quantification of Serotonin.

ZnO nanoparticles-copper metal-organic framework composite on 3D porous nickel foam: a novel electrochemical sensing platform to detect serotonin in blood serum

“…The listed literature explored the combined effect of metal oxide and one or more carbon-based materials. The synthesis strategies employed in some instances were timeconsuming [29,31], and the electrodes were rigid. In certain cases, use of screen-printed electrodes and carbon paste electrodes makes the sensor less sturdy and prone to mechanical damage [29,30,33].…”

Quantification of tramadol and serotonin by cobalt nickel tungstate in real biological samples to evaluate the effect of analgesic drugs on neurotransmitters

“…Serotonin, also known as 5-hydroxytryptamine (5-HT) 9 , is a monoamine neurotransmitter involved in various biological processes. It regulates sleep, enhances mood, and improves heart functioning and appetite 10 . 5-HT is a biomarker for depression and irritable bowel syndrome 11 .…”

Peppermint-Mediated Green Synthesis of Nano ZrO2 and Its Adsorptive Removal of Cobalt from Water

“…Zirconium oxide (ZrO 2 ) is a wide direct band gap semiconductor and considered a multifunctional material due to its unique physical and chemical properties, such as high thermal stability, excellent mechanical characteristics, non-toxicity, and adsorption ability. It was used in many scientific and technological fields, such as catalysis, adsorption, biology, optics, electronics, magnetism, and dental medicine [1][2][3][4][5][6][7][8].…”