ZnO nanoparticles-copper metal-organic framework composite on 3D porous nickel foam: a novel electrochemical sensing platform to detect serotonin in blood serum

Abstract

Herein, we report a simple non-enzymatic electrochemical sensor for the detection of serotonin (5-HT) in blood serum using ZnO oxide nanoparticles-Copper metal-organic framework (MOF) composite on 3D porous nickel foam, namely, ZnO-Cu MOF/NF. The XRD analysis reveals the crystalline nature of synthesized Cu MOF and Wurtzite structure of ZnO nanoparticles, whereas SEM characterization confirms the high surface area of the composite nanostructures. Differential pulse voltammetry (DPV) analysis under optimal conditions yields a wide linear detection range of 1 ng/ml to 1 mg/ml to 5-HT concentrations and a LOD (signal to noise ratio = 3.3) of 0.49 ng/ml, which is well below the lowest physiological concentration of 5-HT. The sensitivity of the fabricated sensor is found to be 0.0606 mA/ng mL-1.cm2 , and it exhibited remarkable selectivity towards serotonin in the presence of various interferants, including dopamine and AA, which coexists in the real biological matrix. Further, successful determination of 5-HT is achieved in the simulated blood serum sample with a good recovery percentage from ~102.5 to ~99.25%. The synergistic combination of the excellent electrocatalytic properties and surface area of the constituent nanomaterials proves the overall efficacy of this novel platform shows immense potential to be used in developing versatile electrochemical sensors.

Ni–Fe layered double oxide on porous nickel foam: a rationalized approach to electrochemical sensing of Atrazine herbicide in water samples

“…This simple LDO-NF substrate was employed as an efficient platform for the detection of ATZ over a wide range from 0.1 fM to 0.5 mM with a LOD of 0.0876 fM ( σ value from calibration curve) and LOQ of 0.265 fM. It is noteworthy to mention that the calculated LOD value was found to be far less than the lowest concentration in the dynamic range of atrazine 34 thus corroborating the efficacy of the sensor for practical applications.…”

Binary Ni–Fe layered double hydroxide on flexible nickel foam for the wide-range voltammetric detection of fibrinogen in simulated body fluid

“…It eliminates the influence of capacitive currents, leading to high sensitivity and better detection limits. Therefore, electrode reactions can be analyzed more precisely [26]. The differential pulse voltammetric experimental conditions are given in table E1.…”

Synergistic integration of Ni-metal organic framework/SnS2 nanocomposite and nickel foam electrode for ultrasensitive and selective electrochemical detection of albumin in simulated human blood serum

“…Electrochemical sensing [12] on the other hand, stands out due to its label-free detection, real-time monitoring, simplicity, costeffectiveness, compatibility with biological samples, and miniaturization potential. It provides an effective and adaptable method for albumin detection in research and clinical settings [13].…”

“…Metal oxides, polymers, and 2D nanomaterials are commonly employed in the detection of albumin [14]. Among these, metal oxides like titanium dioxide (TiO 2 ) and zinc oxide (ZnO) are particularly favored due to their substantial surface area and catalytic properties [13]. However, they often come with drawbacks, such as limited selectivity and sensitivity, which can lead to interference from other biomolecules in the sample.…”