Electrochemical detection of Mycobacterium tuberculosis IS6110 gene fragments based on the gold nanocrystals with uniform morphology and highly exposed high-index facets and target DNA-induced recycling amplification

Application of surfactants in the electrochemical sensing and biosensing of biomolecules and drug molecules

“…This novel surfactantcarbon nanotube-based porous composite structure electrode signicantly improved the detection of dsDNA in a linear range of 4-150 mg mL −1 with a limit of detection (LOD) of 3.06 mg mL −1 . Yuanfeng et al 59 found that cetyltrimethylammonium chloride (CTAC) could form a mixed aqueous solution with potassium bromide and potassium iodide as a so template and synthesized gold nanocrystals by using ascorbic acid to reduce chloroauric acid, and the resulting gold nanocrystals had trioctahedral nanostructures with uniform morphology and highly exposed high-index facets. Using the gold nanocrystals as sensitive material, a novel biosensor for the detection of Mycobacterium tuberculosis IS6110 gene fragments had been fabricated.…”

Recent advances in airborne pathogen detection using optical and electrochemical biosensors

“…The IS6110 gene is found at various sites in the MTB genome. Thus, this gene sequence detection was helpful for MTB diagnosis, and the DPV-based electrochemical technique was widely used to monitor the IS6110 gene [ [124] , [125] , [126] , [127] ]. Arginine contained an active amino group (−NH 2 ), providing an excellent platform for hybridization between the probe DNA and target DNA.…”

“…Using MB as the redox signal developer in the DPV technique, up to 4.4 nM of the IS6110 gene was detected [ 125 ]. However, the proposed method has lower performance than the target DNA-induced recycling amplification and enzyme-assisted signal amplification-based strategies [ 126 , 127 ]. The culture-filtered protein (CFP-10) is also used as a biomarker to diagnose TB at an earlier stage [ [128] , [129] , [130] , [131] ].…”

Nanoparticle-Based Drug Delivery System: The Magic Bullet for the Treatment of Chronic Pulmonary Diseases

“…197 Curcumin Acetate/Monocrotaline, Poloxamer 188, Aloeemodin/pulmonary arterial hypertension, 115 Ciprofloxacin/ cholesterol, soy phosphatidylcholine/Pulmonary drug delivery, 79 Rifampicin, isoniazid, pyrazinamide, and streptomycin/ Starch, ATDs-loaded native starch and SNCs/M. Tuberculosis, 198 IS6110 gene/Chloroauric acid (HAuCl4), cetyltrimethylammonium chloride (CTAC), ascorbic acid, potassium bromide (KBr), potassium iodide (KI), 6-mercaptohexan-1-ol (MCH), thionine (Thi) and tris(2-carboxyethyl) phosphine hydro-chloride (TCEP)/MTB, 199 Rifampicin/ The results indicated that the absorption of insulin was enhanced, and the absorption-enhancing effect was concentrationdependent.…”

“…Curcumin Acetate/Monocrotaline, Poloxamer 188, Aloe-emodin/pulmonary arterial hypertension, Ciprofloxacin/cholesterol, soy phosphatidylcholine/Pulmonary drug delivery, Rifampicin, isoniazid, pyrazinamide, and streptomycin/Starch, ATDs-loaded native starch and SNCs/M. Tuberculosis, IS6110 gene/Chloroauric acid (HAuCl4), cetyltrimethylammonium chloride (CTAC), ascorbic acid, potassium bromide (KBr), potassium iodide (KI), 6-mercaptohexan-1-ol (MCH), thionine (Thi) and tris­(2-carboxyethyl) phosphine hydro- chloride (TCEP)/MTB, Rifampicin/Alginate-cellulose, honey, Calcium chloride dihydrate, sodium hydroxide, hydrogen peroxide and oxalic acid/MTB, Ultrasmall gadolinium oxide/Nitrate hexahydrate, diethylene glycol, diethylene glycol/Lung cancer are some of the recently investigated works to promote pulmonary drug delivery.…”