Electrochemical detection of DNA mismatches using a branch-shaped hierarchical SWNT-DNA nano-hybrid bioelectrode

Mirzapoor, Aboulfazl; Turner, Anthony P. F.; Tiwari, Ashutosh; Ranjbar, Bijan

doi:10.1016/j.msec.2019.109886

Cited by 12 publications

(5 citation statements)

References 53 publications

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“…This event can be monitored in a reagentless manner by tagging one end of the probe with a redox-active label. After the hybridization, the change in the redox current is measured to quantify the specific target DNA sequence. − Based on this approach, various electrochemical genosensors have been developed. − Peptide nucleic acids (PNAs) and locked nucleic acids (LNAs) offer improved hybridization properties over nucleic acids and have also been explored as biorecognition element …”

Section: Biorecognition Elements and Signal Transductionmentioning

confidence: 99%

Advances in Bioelectrode Design for Developing Electrochemical Biosensors

Kalita,

Gogoi,

Minteer

et al. 2023

ACS Meas. Sci. Au

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The critical performance factors such as selectivity, sensitivity, operational and storage stability, and response time of electrochemical biosensors are governed mainly by the function of their key component, the bioelectrode. Suitable design and fabrication strategies of the bioelectrode interface are essential for realizing the requisite performance of the biosensors for their practical utility. A multifaceted attempt to achieve this goal is visible from the vast literature exploring effective strategies for preparing, immobilizing, and stabilizing biorecognition elements on the electrode surface and efficient transduction of biochemical signals into electrical ones (i.e., current, voltage, and impedance) through the bioelectrode interface with the aid of advanced materials and techniques. The commercial success of biosensors in modern society is also increasingly influenced by their size (and hence portability), multiplexing capability, and coupling in the interface of the wireless communication technology, which facilitates quick data transfer and linked decision-making processes in real-time in different areas such as healthcare, agriculture, food, and environmental applications. Therefore, fabrication of the bioelectrode involves careful selection and control of several parameters, including biorecognition elements, electrode materials, shape and size of the electrode, detection principles, and various fabrication strategies, including microscale and printing technologies. This review discusses recent trends in bioelectrode designs and fabrications for developing electrochemical biosensors. The discussions have been delineated into the types of biorecognition elements and their immobilization strategies, signal transduction approaches, commonly used advanced materials for electrode fabrication and techniques for fabricating the bioelectrodes, and device integration with modern electronic communication technology for developing electrochemical biosensors of commercial interest.

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Section: Biorecognition Elements and Signal Transductionmentioning

confidence: 99%

Advances in Bioelectrode Design for Developing Electrochemical Biosensors

Kalita,

Gogoi,

Minteer

et al. 2023

ACS Meas. Sci. Au

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“…CNTs are excellent candidates for use as transducers in electrochemical sensors because of their combination of high electron mobility and electron localization on the CNT surface where they are strongly perturbed by their environment. Mirzapoor et al [ 113 ] synthesized branched CNT structures using two ssDNA sequences attached to the ends of CNTs via a linker DNA. They used this approach for label-free conductivity detection to identify mismatches in hybridized DNA.…”

Section: Non-metallic Conductors On Dna Nanostructuresmentioning

confidence: 99%

Bottom-Up Fabrication of DNA-Templated Electronic Nanomaterials and Their Characterization

et al. 2021

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Bottom-up fabrication using DNA is a promising approach for the creation of nanoarchitectures. Accordingly, nanomaterials with specific electronic, photonic, or other functions are precisely and programmably positioned on DNA nanostructures from a disordered collection of smaller parts. These self-assembled structures offer significant potential in many domains such as sensing, drug delivery, and electronic device manufacturing. This review describes recent progress in organizing nanoscale morphologies of metals, semiconductors, and carbon nanotubes using DNA templates. We describe common substrates, DNA templates, seeding, plating, nanomaterial placement, and methods for structural and electrical characterization. Finally, our outlook for DNA-enabled bottom-up nanofabrication of materials is presented.

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“…The limited surface area and weak interactions of PDA nanoparticles hamper their effectiveness as drug carriers due to the low loading capacity 9 and potential drug leakage. 10 "Carrierdrug" hybrid assembly could be defined as fabricating the nanostructures by direct combination of the carrier and drugs by reaching a certain equilibrium state of intermolecular interactions, 11,12 and such a strategy can take the advantage of exploring the possibility of enhancing the drug loading capability of PDA nanoparticles by loading cargos during the process of dopamine polymerization.…”

Section: Introductionmentioning

confidence: 99%