Electrochemical detection of carcinoembryonic antigen

Gu, Xiaosong; She, Zhe; Ma, Tianxiao; Tian, Shu; Kraatz, Heinz‐Bernhard

doi:10.1016/j.bios.2017.12.014

Cited by 132 publications

(45 citation statements)

References 46 publications

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“…Gu et al [ 115 ] integrated ferrocene (Fc) derivative and AuNPs into their biosensor for CEA detection in order to increase the conductivity of the sensing surfaces and increase ferrocene loading. Firstly, AuNPs were reduced from chloroauric acid with trisodium citrate as a reducing agent, and subsequently, polyclonal secondary anti-CEA antibodies were immobilized onto their surface via physisorption.…”

Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

“…After CEA was affinity captured on the modified electrode, the sandwich configuration was completed by incubation with a signal probe. The developed biosensor exhibited LOD of approximately 0.01 ng/mL (a linear range up to 20 ng/mL), when detecting CEA using a SWV method with a good performance after storage for 3 weeks (91.8% of the original response) [ 115 ] (Approach 2).…”

Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Gajdošová

Lorencová

Kasák

et al. 2020

Sensors

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This comprehensive review paper describes recent advances made in the field of electrochemical nanobiosensors for the detection of breast cancer (BC) biomarkers such as specific genes, microRNA, proteins, circulating tumor cells, BC cell lines, and exosomes or exosome-derived biomarkers. Besides the description of key functional characteristics of electrochemical nanobiosensors, the reader can find basic statistic information about BC incidence and mortality, breast pathology, and current clinically used BC biomarkers. The final part of the review is focused on challenges that need to be addressed in order to apply electrochemical nanobiosensors in a clinical practice.

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Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Gajdošová

Lorencová

Kasák

et al. 2020

Sensors

View full text Add to dashboard Cite

show abstract

“…As one of the tumor biomarkers, the average CEA concentration in a healthy human is less than 5 μg L −1 , while serum CEA levels above 20 μg L −1 indicates the presence of cancer .…”

Section: Competition Effect: Self‐powered Carcinoembryonic Antigen (Cmentioning

confidence: 99%

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

Liu

et al. 2018

Electroanalysis

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The application of biofuel cells (BFCs) for the construction of self‐powered electrochemical biosensors has recently received enormous attention with exciting advancements. The principle of BFCs for electrochemical biosensing is that the BFCs’ power output which is directly extracted by the biological reactions with the help of biocatalysts is closely related to the analyte's concentration. Such unique feature makes BFCs based electrochemical biosensors with two‐electrode system to be operated without the need of any external power source, which provides a more effective way for the miniaturization and convenient construction of electrochemical biosensors than the traditional electrochemical biosensors with three‐electrode system. Following our previous reviews (Electroanalysis 2012, 24, 197–209; Electroanalysis 2015, 27, 1786–1801), the current review is focused on the recent development and advances in the construction of BFCs based self‐powered electrochemical biosensors which are reported in the years between 2015 and 2018, with a particular emphasis on their possible practical applications in the fields of medical diagnosis, environmental monitoring, food analysis and wearable devices. For these reported BFCs‐based self‐powered electrochemical biosensors, the design approaches are still within the scope of effects (i.e., substrate, inhibition, blocking, gene regulation, enzyme, co‐stabilization, competition, and hybrid effects) summarized by our previous reviews. The outlook, challenges and developing tendency of the future research for the construction of BFCs based self‐powered electrochemical biosensor are discussed in the end. We expect that the advanced electrochemical biosensors based on BFCs with the unique self‐powered capability will continue attracting increasing research interest and lead to new opportunities in various attractive applications related to analytical chemistry.

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“…The fabrication of an effective and efficient diagnostic tool for the detection of cancer and monitoring its progression during therapy is a vital task in biomedical analysis. The possibilities of such analysis in oncology have been enhanced by the discovery of tumor biomarkers such as alpha-fetoprotein, CA125, prostate-specific antigen, cytokeratin 19 fragment and carcinoembryonic antigen (CEA) to name a few [1,2].…”

Section: Introductionmentioning

confidence: 99%

An Exfoliated Graphite-Based Electrochemical Immunosensor on a Dendrimer/Carbon Nanodot Platform for the Detection of Carcinoembryonic Antigen Cancer Biomarker

2019

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An electrochemical immunosensor for the quantification of carcinoembryonic antigen (CEA) using a nanocomposite of polypropylene imine dendrimer (PPI) and carbon nanodots (CNDTs) on an exfoliated graphite electrode (EG) is reported. The carbon nanodots were prepared by pyrolysis of oats. The nanocomposites (PPI and CNDTs) were characterized using X-ray powder diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron microscopy (HRTEM) and scanning electron microscopy (SEM). The proposed immunosensor was prepared on an exfoliated graphite electrode sequentially by drop coating CNDTs, the electrodeposition of G2-PPI (generation 2 poly (propylene imine) dendrimer), the immobilization of anti-CEA on the modified electrode for 80 min at 35 °C, and dropping of bovine serum albumin (BSA) to minimize non-specific binding sites. Cyclic voltammetry was used to characterize each stage of the fabrication of the immunosensor. The proposed immunosensor detected CEA within a concentration range of 0.005 to 300 ng/mL with a detection limit of 0.00145 ng/mL by using differential pulse voltammetry (DPV). The immunosensor displayed good stability and was also selective in the presence of some interference species such as ascorbic acid, glucose, alpha-fetoprotein, prostate-specific antigen and human immunoglobulin. Furthermore, the fabricated immunosensor was applied in the quantification of CEA in a human serum sample, indicating its potential for real sample analysis.

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Electrochemical detection of carcinoembryonic antigen

Cited by 132 publications

References 46 publications

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Recent Advances in the Construction of Biofuel Cells Based Self‐powered Electrochemical Biosensors: A Review

An Exfoliated Graphite-Based Electrochemical Immunosensor on a Dendrimer/Carbon Nanodot Platform for the Detection of Carcinoembryonic Antigen Cancer Biomarker

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