Electrochemical detection for flow analysis and liquid chromatography: present status and some roads to the future

Štulı́k, Karel

doi:10.1016/0003-2670(93)80188-q

Analytica Chimica Acta

1993

DOI: 10.1016/0003-2670(93)80188-q

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Electrochemical detection for flow analysis and liquid chromatography: present status and some roads to the future

Karel Štulı́k

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Cited by 19 publications

References 40 publications

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Determination of Buprenorphine in Pharmaceuticals and Human Urine by Adsorptive Stripping Voltammetry in Batch and Flow Systems

2000

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The adsorption of buprenorphine on carbon paste electrodes has been studied by cyclic (CV) and differential pulse voltammetry (DPV). By applying a simple electrode pretreatment good reproducibility of the current signal is obtained (RSD 0.85 %, n 6 in CV and RSD 0. 35 %, n 6 in DPV for a 5.0610 À7 M buprenorphine concentration in BR buffer pH 9.0). These methods permit a very sensitive (LD 2.0610 À8 M) and selective determination. They were applied to the quantitation of buprenorphine in human urine coming from subjects following buprenorphine treatment. The methodology was coupled to a¯ow system incorporating a thin-layer¯ow cell. A linear response was obtained in the concentration range comprised between 1.0610 À8 and 8.0610 À7 M. The application to the determination of this molecule in pharmaceuticals (vials and tablets) and human urine without any sample pretreatment is studied.

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Determination of Buprenorphine in Pharmaceuticals and Human Urine by Adsorptive Stripping Voltammetry in Batch and Flow Systems

2000

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Pneumolysin ELISA with Adsorptive Voltammetric Detection of Indigo in a Flow System

2001

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Sensitive electrochemical detection in a flow system is applied to the determination of pneumolysin by an ELISA procedure. Alkaline phosphatase is the enzyme used in the immunoassay and 3‐indoxyl phosphate acts as substrate. The attractive properties of the indigo electrochemical detection, product of the enzymatic hydrolysis, such as sensitive response by alternating current voltammetry, low potential detection and adsorption on carbon paste electrodes are exploited with analytical purposes. The flow system, provided with a sample aspiration mechanism, automates the methodology and decreases analysis time. Parameters related either to the electrochemical technique, to the flow system or to the enzymatic reaction are optimized. Calibration plots obtained under different conditions are reported.

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A conductometric detector for capillary separations

et al. 1996

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A simple electrochemical cell has been constructed for conductometric detection in capillary electrophoresis or HPLC. A platinum ring electrode Is chemically deposited at the capillary end and the other electrode, a platinum wire, is immersed, together with the capillary, in a vessel containing the running buffer or the mobile phase used. The cell has been tested on a model system and its operational parameters have been discussed. The measurement i:; very sensitive (a limit of determination of ca. 3 x M for potassium ions) and the detector response is rapid, comparable with that of the UV photometric detector. The dynamic range is wide (at least five concentration decades) but is nonlinear at high concentrations.

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Electrochemical detection for flow analysis and liquid chromatography: present status and some roads to the future

Cited by 19 publications

References 40 publications

Determination of Buprenorphine in Pharmaceuticals and Human Urine by Adsorptive Stripping Voltammetry in Batch and Flow Systems

Determination of Buprenorphine in Pharmaceuticals and Human Urine by Adsorptive Stripping Voltammetry in Batch and Flow Systems

Pneumolysin ELISA with Adsorptive Voltammetric Detection of Indigo in a Flow System

A conductometric detector for capillary separations

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