Electrochemical coupling of mono and dihalopyridines catalyzed by nickel complex in undivided cell

Synthetic Organic Electrochemical Methods Since 2000: On the Verge of a Renaissance

“…Electrochemical homocoupling of (hetero)aryl halides (such as 2-halopyridines) through this mechanism has been reported. 759,760 Cross-couplings between aryl halides and heteroaryl halides through similar mechanisms have also been reported. 761−764 Various nitrogen-rich heterocycles, which are challenging targets for conventional Suzuki coupling reaction, were shown to undergo electroreductive couplings in good yields (Figure 44F).…”

“…Electrochemical homocoupling of (hetero)aryl halides (such as 2-halopyridines) through this mechanism has been reported. 759,760 …”

Nickel-Catalyzed Reductive Cross-Couplings: New Opportunities for Carbon–Carbon Bond Formations through Photochemistry and Electrochemistry

“…Besides these achievements, the nickel-catalyzed electrochemical method was also applied to aryl-heteroarybond formation reactions. In this regard, Léonel and coworkers [99][100][101][102] reported several electroreductive nickelcatalyzed cross-coupling reactions of aryl halides and heteroaryls, such as 3-chloro-6-methoxypyridazines,…”

Dehydrogenative Synthesis of 2,2′‐Bipyridyls through Regioselective Pyridine Dimerization

“…[3] Moreover,w eh ave found that 2,2'-bipyridyls play ak ey role in CÀHf unctionalization reactions such as CÀHa rylation of 5-membered heteroaromatics [4a] and aromatic C À Himidation. [5] Although these methods are reliable and well-established, additional steps to prepare 2-halogenated pyridines are required and it is therefore usually an expensive and time-consuming process.M oreover,h alogenation of pyridine ring systems generally suffers from poor regioselectivity and requires harsh reaction conditions. [5] Although these methods are reliable and well-established, additional steps to prepare 2-halogenated pyridines are required and it is therefore usually an expensive and time-consuming process.M oreover,h alogenation of pyridine ring systems generally suffers from poor regioselectivity and requires harsh reaction conditions.…”