Electrochemical biosensors based on dendrimers

Evtyugin, G. A.; Stoikova, E. E.

doi:10.1134/s1061934815050044

Cited by 13 publications

(7 citation statements)

References 83 publications

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“…Figure i shows the DPV for the reduction signal of MB with probe I after hybridization with target dsDNA (probe II). The highest MB reduction signal is observed with probe I alone, as MB has a strong affinity for free guanine bases and hence the greatest amount of MB accumulation occurs at this surface . An obvious decrease in the voltammetric peak current is observed after duplex formation (Figure i), as the interaction between MB and guanine residues of the probe has been prevented by hybrid formation on the electrode surface.…”

Section: Resultsmentioning

confidence: 96%

Layer-by-Layer-Assembled AuNPs-Decorated First-Generation Poly(amidoamine) Dendrimer with Reduced Graphene Oxide Core as Highly Sensitive Biosensing Platform with Controllable 3D Nanoarchitecture for Rapid Voltammetric Analysis of Ultratrace DNA Hybridization

Jayakumar

Camarada

Dharuman

et al. 2018

ACS Appl. Mater. Interfaces

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The structure and electrochemical properties of layer-by-layer-assembled gold nanoparticles (AuNPs)-decorated first-generation (G1) poly(amidoamine) dendrimer (PD) with reduced graphene oxide (rGO) core as a highly sensitive and label-free biosensing platform with a controllable three-dimensional (3D) nanoarchitecture for the rapid voltammetric analysis of DNA hybridization at ultratrace levels were characterized. Mercaptopropinoic acid (MPA) was self-assembled onto Au substrate, then GG1PD formed by the covalent functionalization between the amino terminals of G1PD and carboxyl terminals of rGO was covalently linked onto MPA, and finally AuNPs were decorated onto GG1PD by strong physicochemical interaction between AuNPs and -OH of rGO in GG1PD, which was characterized through different techniques and confirmed by computational calculation. This 3D controllable thin-film electrode was optimized and evaluated using [Fe(CN)] as the redox probe and employed to covalently immobilize thiol-functionalized single-stranded DNA as biorecognition element to form the DNA nanobiosensor, which achieved fast, ultrasensitive, and high-selective differential pulse voltammetric analysis of DNA hybridization in a linear range from 1 × 10 to 1 × 10 g m with a low detection limit of 9.07 × 10 g m. This work will open a new pathway for the controllable 3D nanoarchitecture of the layer-by-layer-assembled metal nanoparticles-functionalized lower-generation PD with two-dimensional layered nanomaterials as cores that can be employed as ultrasensitive and label-free nanobiodevices for the fast diagnosis of specific genome diseases in the field of biomedicine.

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Section: Resultsmentioning

confidence: 96%

Layer-by-Layer-Assembled AuNPs-Decorated First-Generation Poly(amidoamine) Dendrimer with Reduced Graphene Oxide Core as Highly Sensitive Biosensing Platform with Controllable 3D Nanoarchitecture for Rapid Voltammetric Analysis of Ultratrace DNA Hybridization

Jayakumar

Camarada

Dharuman

et al. 2018

ACS Appl. Mater. Interfaces

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“…Electrochemical biosensors measure change in current, voltage or conductance resulted from oxidation of analytes. Electrochemical biosensors are divided into conductimetric biosensors, potentiometric/voltametric biosensors and amperometric biosensors [87,88].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Polyphenol oxidase (PPO) based biosensors for detection of phenolic compounds: A Review

2017

J App Biol Biotech

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The present review summarizes the literature on applications and development of polyphenol oxidase-based biosensors for detection of phenolic compounds present in industrial waste waters. Phenolic compounds including phenol and its derivatives: bisphenol A, catechol, and cresol are widely used in industrial processes. These compounds cause toxicity to living organisms and can be bioaccumulated in environment and food chain. Global production of phenolic compounds is about 50,000 tons per annum. The presence of these compounds in air, water, and food poses toxicity risks to human health and environment. Monitoring of concentration of phenolic compounds is necessary to avoid the risks posed by these compounds. Conventional methods for the detection and quantification of these compounds include laboratory-based spectrophotometric and chromatographic methods. Biosensors can be an efficient alternative to conventional methods due to their inherent specificity, simplicity and quick responsiveness. Biosensors can play an important role to improve the quality of life. Polyphenol oxidasebased biosensors can potentially be applied to detect phenolic compounds in various biological and non-biological materials.

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“…Dendrimers are a unique class of monodisperse macromolecules that differ from other polymers by their well-ordered controllable structure and multifunctional periphery. The various structures of dendritic macromolecules as well as the possibility of direct modification of the external dendrimer layer and the internal space of dendrimers determine their numerous possible applications [1][2][3][4][5][6][7][8][9]. The knowledge accumulated to date on dendrimers makes it possible to implement a "from quantity to quality" approach, namely, from expanding the scope of the library of dendritic macromolecules with various chemical structures to the development of new dendrimer-based nanomaterials and discovery of their most promising application areas.…”

Section: Introductionmentioning

confidence: 99%

“…The results of the theoretical assessment of the density of polyphenylene dendrimers with "exploded" branching units (~0.03 g/cm 3 [13,23]) and calculated solvent accessible surface area of a single dendrimer as a structural element of the material [24] reveal the possibility of materials with a high specific surface area based on rigid-chain dendrimers. The specific surface area values obtained in the calculations depend on the generation number and decrease as the latter increases.…”

Section: Introductionmentioning

confidence: 99%

Porosity of Rigid Dendrimers in Bulk: Interdendrimer Interactions and Functionality as Key Factors

et al. 2021

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The porous structure of second- and third-generation polyphenylene-type dendrimers was investigated by adsorption of N2, Ar, and CO2 gases, scanning electron microscopy and small-angle X-ray spectroscopy. Rigid dendrimers in bulk are microporous and demonstrate a molecular sieve effect. When using CO2 as an adsorbate gas, the pore size varies from 0.6 to 0.9 nm. This is most likely due to the distances between dendrimer macromolecules or branches of neighboring dendrimers, whose packing is mostly realized due to intermolecular interactions, in particular, π–π interactions of aromatic fragments. Intermolecular interactions prevent the manifestation of the porosity potential inherent to the molecular 3D structure of third-generation dendrimers, while for the second generation, much higher porosity is observed. The maximum specific surface area for the second-generation dendrimers was 467 m2/g when measured by CO2 adsorption, indicating that shorter branches of these dendrimers do not provide dense packing. This implies that the possible universal method to create porous materials for all kinds of rigid dendrimers is by a placement of bulky substituents in their outer layer.

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Electrochemical biosensors based on dendrimers

Cited by 13 publications

References 83 publications

Layer-by-Layer-Assembled AuNPs-Decorated First-Generation Poly(amidoamine) Dendrimer with Reduced Graphene Oxide Core as Highly Sensitive Biosensing Platform with Controllable 3D Nanoarchitecture for Rapid Voltammetric Analysis of Ultratrace DNA Hybridization

Layer-by-Layer-Assembled AuNPs-Decorated First-Generation Poly(amidoamine) Dendrimer with Reduced Graphene Oxide Core as Highly Sensitive Biosensing Platform with Controllable 3D Nanoarchitecture for Rapid Voltammetric Analysis of Ultratrace DNA Hybridization

Polyphenol oxidase (PPO) based biosensors for detection of phenolic compounds: A Review

Porosity of Rigid Dendrimers in Bulk: Interdendrimer Interactions and Functionality as Key Factors

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