Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection

Xiong, Xiaolu; Zhu, Peng; Li, Shanshan; Jiang, Yujiu; Ma, Yurong; Shi, Qingfan; Zhang, Xu; Shu, Xi; Wang, Zhiwei; Sun, Linfeng; Han, Junfeng

doi:10.1007/s00604-022-05365-8

Cited by 11 publications

(5 citation statements)

References 47 publications

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“…Using topological materials, this study provides an effective method of developing biosensors that can be used for the determination of clinical markers and monitoring [40]. In another similar study by Xiong et al [41], a large-size Bi 2 Se 3 tape electrode (BTE) was prepared using a single crystal of 2 cm × 1 cm × 0.5 cm. For HIV-1 DNA electrochemical sensing, flexible BTE was explored as an efficient bioplatform for loading Au nanoparticles and probe DNA.…”

Section: Graphene-based Biosensorsmentioning

confidence: 99%

“…It was believed that Bi 2 Se 3 's intrinsic surface state facilitates electron transfer due to its outstanding performance. Hence, the BTE electrochemical biosensor platform showed great potential for the detection of DNA biomarkers in a sensitive manner [41]. An innovative approach to testing HIV is self-testing, which allows individuals to collect their own specimens, conduct tests, and interpret the results privately.…”

Section: Graphene-based Biosensorsmentioning

confidence: 99%

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Development of nanobiosensors for human immunodeficiency virus detection—a mini review

Mudenkattil

Girigoswami

Jayaprakash

et al. 2022

Exploration of Medicine

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Acquired immunodeficiency syndrome (AIDS) is a global disease caused by human immunodeficiency virus (HIV). About 50 million people have died worldwide due to HIV-1 infection alone. HIV is a primary sexually transmitted infection but can also spread via breastfeeding, blood transfer, organ transfer, etc. Early detection with the maintenance of the disease is the only way to reduce the spread and severity of the disease. There are many conventional techniques for the detection of the virus. Still, recently nano-based diagnostic method remains a little ahead of these techniques due to advancements in nanotechnology. Nanomaterial-based biosensors constitute a significant part of the discussion because of their high sensitivity and accuracy. Nanobiosensors like electronic nano biosensors, quantum dot (QD)-based biosensors, optical biosensors, electronic biosensors, electrochemiluminescence nanosensors, field-effect transistor (FET) biosensors, surface acoustic wave (SAW) biosensors, graphene-based biosensors, etc. have been widely used for detecting HIV in human blood samples. All these biosensors offer promising results in the detection of the virus. In this article, different types of nanobiosensors and their application in the field of diagnosis and maintenance of HIV was reviewed.

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Section: Graphene-based Biosensorsmentioning

confidence: 99%

Section: Graphene-based Biosensorsmentioning

confidence: 99%

Development of nanobiosensors for human immunodeficiency virus detection—a mini review

Mudenkattil

Girigoswami

Jayaprakash

et al. 2022

Exploration of Medicine

View full text Add to dashboard Cite

show abstract

“…30–36 The reported topological material Bi 2 Se 3 , as an electrochemical electrode, can provide a good microenvironment for the immobilization of biomolecules and promote electron transfer through the electrode/electrolyte interface, which improves the detection sensitivity of biosensors. 37–39 However, the reported Bi 2 Se 3 based biosensors were mainly composed of nanoparticles and nanosheets with many defects and boundaries, 40,41 which increased the nonspecific adsorption and decreased the repeatability and selectivity of the biosensors.…”

Section: Introductionmentioning

confidence: 99%

Topological insulator Bi₂Se₃ based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Zhu

Jiang

et al. 2023

J. Mater. Chem. B

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“…In particular, Bi 2 Se 3 has a single Dirac cone on its surface states, and the electrons on this unique topological surface state can realize high-speed and low-dissipation electron transmission. − Bi 2 Se 3 is a critical rival for HOPG, as the topological surface states ensure a 2D Dirac surface surrounding the bulk material, while in HOPG, it is only observed at the atomic monolayer (graphene) . These properties make Bi 2 Se 3 reliable for DNA assembly and sensitive biosensors. − However, research about the assembly behavior of DNA molecules on the Bi 2 Se 3 surface and biosensing application is scarce. − This is probably because the reported Bi 2 Se 3 nanoparticles and nanosheets synthesized by the solvothermal and hydrothermal methods − have many defects and boundaries.…”

Section: Introductionmentioning

confidence: 99%

“…Bi 2 Se 3 single crystals with a dimension of 2 × 1 × 0.5 cm 3 were synthesized by our lab. 53 Bi 2 Se 3 sheets were obtained by peeling off from single crystals.…”

Section: ■ Introductionmentioning

confidence: 99%

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor

et al. 2023

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Controlling the assembly of DNA in order on a suitable electrode surface is of great significance for biosensors and disease diagnosis, but it is full of challenges. In this work, we creatively assembled DNA on the surface of octadecylamine (ODA)-modified topological insulator (Tls) Bi 2 Se 3 and developed an electrochemical biosensor to detect biomarker DNA of coronavirus disease 2019 (COVID-19). A high-quality Bi 2 Se 3 sheet was obtained from a single crystal synthesized in our lab. A uniform ODA layer was coated in argon by chemical vapor deposition (CVD). We observed and analyzed the assembly and mechanism of single-strand DNA (ssDNA) and double-strand DNA (dsDNA) on the Bi 2 Se 3 surface through atomic force microscopy (AFM) and molecular dynamics (MD) simulations. The electrochemical signal revealed that the biosensor based on the DNA/ODA/Bi 2 Se 3 electrode has a wide linear detection range from 1.0 × 10 −12 to 1.0 × 10 −8 M, with the limit of detection as low as 5 × 10 −13 M. Bi 2 Se 3 has robust surface states and improves the electrochemical signal-to-noise ratio, while the uniform ODA layer guides high-density ordered DNA, enhancing the sensitivity of the biosensor. Our work demonstrates that the ordered DNA/ODA/Bi 2 Se 3 electrode surface has great application potential in the field of biosensing and disease diagnosis.

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Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection

Cited by 11 publications

References 47 publications

Development of nanobiosensors for human immunodeficiency virus detection—a mini review

Development of nanobiosensors for human immunodeficiency virus detection—a mini review

Topological insulator Bi₂Se₃ based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor

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Electrochemical biosensor based on topological insulator Bi2Se3 tape electrode for HIV-1 DNA detection

Cited by 11 publications

References 47 publications

Development of nanobiosensors for human immunodeficiency virus detection—a mini review

Development of nanobiosensors for human immunodeficiency virus detection—a mini review

Topological insulator Bi2Se3 based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Ordered Assembly of DNA on Topological Insulator Bi2Se3 and Octadecylamine for a Sensitive Biosensor

Contact Info

Product

Resources

About

Topological insulator Bi₂Se₃ based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor