Topological insulator Bi<sub>2</sub>Se<sub>3</sub> based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Wu, Yetong; Zhu, Peng; Jiang, Yujiu; Zhang, Xu; Wang, Zhiwei; Xie, Bingteng; Song, Tinglu; Zhang, Fulai; Luo, Aiqin; Li, Shanshan; Xiong, Xiaolu; Han, Junfeng

doi:10.1039/d2tb01760a

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…Therefore, early diagnosis and effective treatment of inflammation are needed to prevent long-term negative effects on the work and quality of life of patients. Proteins such as interferon-γ (IFN-γ) 87 , tumor necrosis factor-alpha (TNF-α) 88 , anti-cyclic citrullinated peptide antibody (anti-CCP) 89 , and eosinophilic cationic protein (ECP) 90 are biomarkers of inflammatory diseases such as autoimmune hepatitis, rheumatoid arthritis (RA), and allergic rhinitis (AR) and are used for diagnosis.…”

Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

“…Inflammatory cytokines such as TNF-α, IFN-γ and oncostatin M (OSM) have been found to be associated with many infectious and inflammatory diseases (such as RA, autoimmune hepatitis, and inflammatory bowel disease) 87 , 97 , 98 and can be used as markers for inflammatory disease detection. Pinto et al 88 developed a label-free ultrasensitive immunosensor for the detection of TNF-α.…”

Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

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Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology. Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects. Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology. However, the active centers of protein biomarkers are surrounded by a peptide matrix, which hinders charge transfer and results in insufficient sensor sensitivity. Therefore, electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors. In this review, we summarize recent reports of electrochemical biosensors for protein biomarker detection. We highlight the latest research on electrochemical protein biosensors for the detection of cancer, viral infectious diseases, inflammation, and other diseases. The corresponding sensitive materials, transducer structures, and detection principles associated with such biosensors are also addressed generally. Finally, we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

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Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

Section: Application Of Electrochemical Protein Sensors In the Detect...mentioning

confidence: 99%

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Guo,

Zhao,

Huang

et al. 2024

Microsyst Nanoeng

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“…In particular, Bi 2 Se 3 has a single Dirac cone on its surface states, and the electrons on this unique topological surface state can realize high-speed and low-dissipation electron transmission. − Bi 2 Se 3 is a critical rival for HOPG, as the topological surface states ensure a 2D Dirac surface surrounding the bulk material, while in HOPG, it is only observed at the atomic monolayer (graphene) . These properties make Bi 2 Se 3 reliable for DNA assembly and sensitive biosensors. − However, research about the assembly behavior of DNA molecules on the Bi 2 Se 3 surface and biosensing application is scarce. − This is probably because the reported Bi 2 Se 3 nanoparticles and nanosheets synthesized by the solvothermal and hydrothermal methods − have many defects and boundaries.…”

Section: Introductionmentioning

confidence: 99%

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor

et al. 2023

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Controlling the assembly of DNA in order on a suitable electrode surface is of great significance for biosensors and disease diagnosis, but it is full of challenges. In this work, we creatively assembled DNA on the surface of octadecylamine (ODA)-modified topological insulator (Tls) Bi 2 Se 3 and developed an electrochemical biosensor to detect biomarker DNA of coronavirus disease 2019 (COVID-19). A high-quality Bi 2 Se 3 sheet was obtained from a single crystal synthesized in our lab. A uniform ODA layer was coated in argon by chemical vapor deposition (CVD). We observed and analyzed the assembly and mechanism of single-strand DNA (ssDNA) and double-strand DNA (dsDNA) on the Bi 2 Se 3 surface through atomic force microscopy (AFM) and molecular dynamics (MD) simulations. The electrochemical signal revealed that the biosensor based on the DNA/ODA/Bi 2 Se 3 electrode has a wide linear detection range from 1.0 × 10 −12 to 1.0 × 10 −8 M, with the limit of detection as low as 5 × 10 −13 M. Bi 2 Se 3 has robust surface states and improves the electrochemical signal-to-noise ratio, while the uniform ODA layer guides high-density ordered DNA, enhancing the sensitivity of the biosensor. Our work demonstrates that the ordered DNA/ODA/Bi 2 Se 3 electrode surface has great application potential in the field of biosensing and disease diagnosis.

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Electrochemical biosensor for sensitive detection of SARS-CoV-2 gene fragments using Bi2Se3 topological insulator

Bai,

Jiang,

Tan

et al. 2024

Bioelectrochemistry

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Topological insulator Bi₂Se₃ based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Abstract: Interferon-γ (IFN-γ) is one of the crucial inflammatory cytokines as an early indicator of multiple diseases. A fast, simple, sensitive and reliable IFN-γ detection method is valuable for early diagnosis...

Cited by 5 publications

References 46 publications

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor

Electrochemical biosensor for sensitive detection of SARS-CoV-2 gene fragments using Bi2Se3 topological insulator

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Topological insulator Bi2Se3 based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Abstract: Interferon-γ (IFN-γ) is one of the crucial inflammatory cytokines as an early indicator of multiple diseases. A fast, simple, sensitive and reliable IFN-γ detection method is valuable for early diagnosis...

Cited by 5 publications

References 46 publications

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Electrochemical protein biosensors for disease marker detection: progress and opportunities

Ordered Assembly of DNA on Topological Insulator Bi2Se3 and Octadecylamine for a Sensitive Biosensor

Electrochemical biosensor for sensitive detection of SARS-CoV-2 gene fragments using Bi2Se3 topological insulator

Contact Info

Product

Resources

About

Topological insulator Bi₂Se₃ based electrochemical aptasensors for the application of sensitive detection of interferon-γ

Ordered Assembly of DNA on Topological Insulator Bi₂Se₃ and Octadecylamine for a Sensitive Biosensor