Electrochemical behavior of superoxide anion radical towards quinones: a mechanistic approach

Muhammad, Haji; Hanif, Muddasir; Tahiri, Iftikhar Ahmad; Versiani, Muhammad Ali; Shah, Faheem; Khaliq, Obaid; Ali, Syed Tahir; Ahmed, Safeer

doi:10.1007/s11164-018-3496-8

Cited by 12 publications

(28 citation statements)

References 25 publications

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“…The 1 H and 13 C spectra of the isomer 2b can be divided into two regions; aromatic and aliphatic (Fig. S5, Fig.…”

Section: Results and Discussion Retrosynthetic Analysis And Strategy For Chlorinated Maprotiline Analoguementioning

confidence: 99%

“…S6). In the aromatic region a multiple region at δ 7.21-7.45 ppm assigned for the protons integrated for anthracene rings and this region exhibited in 13 C spectrum as peaks at δ 123.45-144.06 ppm. In the aliphatic portion, there are a triplet signal at δ 4.44 ppm with a coupling constant J 0.8 Hz assigned for the protons integrated for carbon 10 (C10) and doublet signal δ 4.72 ppm with a coupling constant J 0.8 Hz assigned for the protons integrated for carbon 9 (C9).…”

Section: Results and Discussion Retrosynthetic Analysis And Strategy For Chlorinated Maprotiline Analoguementioning

confidence: 99%

“…In the aliphatic portion, there are a triplet signal at δ 4.44 ppm with a coupling constant J 0.8 Hz assigned for the protons integrated for carbon 10 (C10) and doublet signal δ 4.72 ppm with a coupling constant J 0.8 Hz assigned for the protons integrated for carbon 9 (C9). These signals are corresponding to the peaks appeared at δ 43.69 and 45.20 ppm in 13 C spectrum respectively; these signals are considered one of the two markers indicating for DA cycloaddition adduct 2b (Fig. S5b).…”

Section: Results and Discussion Retrosynthetic Analysis And Strategy For Chlorinated Maprotiline Analoguementioning

confidence: 99%

“…Perkin Elmer 240 elemental analyzer was used to obtain infra-red (IR) spectrum. 1 H and 13 C-NMR spectra were recorded on either Joel 400 MHz or Bruker 500 MHz. Mass spectra (MS) and high resolution mass spectra (HRMS) data were obtained on a Q-Tof Premier UPLC-MS.…”

Section: Chemistry Protocolsmentioning

confidence: 99%

“…From biological point of view; 1,5-dichloroanthracene itself shows antioxidant activities through a proton transfer mechanism [13]. A variety of 1,5-dichloroanthracene-and anthraquinone-related derivatives proved to possess an anti-in ammatory activity with no signi cant cytotoxicity in human neutrophils [14] another anthracene analogues displayed potent anti-in ammatory activity against superoxide anion production and induced apoptosis, thus exerting antitumor activity [15].…”

Section: Introductionmentioning

confidence: 99%

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1,5-Dichloroethanoanthracene Derivatives as Antidepressant Maprotiline Analogues: Synthesis and DFT Computational Calculations

Sultan¹,

Pillai²,

Alzahrani³

2021

Preprint

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The chlorinated tetracyclic 1,5-dichloro-9,10-dihydro-9,10-ethanoanthracen-12-yl)-N-methylmethanamine 1, a maprotiline analogue, has been synthesized via reduction and Diels–Alder reaction followed by reductive amination of Aldehyde 2. Density Functional Theory calculations were performed to identify the possible isomers of the intermediate compound aldehyde 2, these calculations were in a good agreement with experimental result where aldehyde 2 could exist in three isomers with comparable energies. In addition, the side chain of this aldehyde 2 was extended via Wittig reaction to obtain the unsaturated ester 5 that subjected to selective olefinic catalytic hydrogenation to obtain the corresponding saturated ester 6. 1D-NMR (DEPT) and 2D-NMR (HSQC, DQF-COSY) techniques were recruited for structural elucidation in addition to HRMS.

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“…The 1 H and 13 C spectra of the isomer 2b can be divided into two regions; aromatic and aliphatic (Fig. S5, Fig.…”

Section: Results and Discussion Retrosynthetic Analysis And Strategy For Chlorinated Maprotiline Analoguementioning

confidence: 99%

Section: Results and Discussion Retrosynthetic Analysis And Strategy For Chlorinated Maprotiline Analoguementioning

confidence: 99%

Section: Results and Discussion Retrosynthetic Analysis And Strategy For Chlorinated Maprotiline Analoguementioning

confidence: 99%

Section: Chemistry Protocolsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

1,5-Dichloroethanoanthracene Derivatives as Antidepressant Maprotiline Analogues: Synthesis and DFT Computational Calculations

Sultan¹,

Pillai²,

Alzahrani³

2021

Preprint

View full text Add to dashboard Cite

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Reactivities of quercetin and metallo‐quercetin with superoxide anion radical and molecular oxygen

Lewis

Wallace

Peterson

et al. 2021

Electrochemical Science Adv

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This work describes the differential quenching of molecular oxygen and superoxide anion radical (O2˙–) by (metallo)‐quercetin (QCR) complexes. The in situ complexes were more reactive with molecular oxygen than preformed complexes. By adjusting the potential range, it was determined that Cu2+ complexes exhibited similar superoxide anion radical (O2˙–) quenching ability as free QCR. The Fe3+ complexes were less reactive than free QCR or Cu2+ complexes. The data indicate that metal ions significantly modulated reactivity of QCR with O2˙– or molecular oxygen, and may regulate antioxidant activity and reactive oxygen species levels in a complex biological setting.

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Electrochemical determination of antioxidant activity and HPLC profiling of some dry fruits

et al. 2019

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Electrochemical behavior of superoxide anion radical towards quinones: a mechanistic approach

Cited by 12 publications

References 25 publications

1,5-Dichloroethanoanthracene Derivatives as Antidepressant Maprotiline Analogues: Synthesis and DFT Computational Calculations

1,5-Dichloroethanoanthracene Derivatives as Antidepressant Maprotiline Analogues: Synthesis and DFT Computational Calculations

Reactivities of quercetin and metallo‐quercetin with superoxide anion radical and molecular oxygen

Electrochemical determination of antioxidant activity and HPLC profiling of some dry fruits

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