Electrochemical behavior and square wave voltammetric determination of aristolochic acid-I

Abstract

Electroanalytical procedure for the determination of nephrotoxic aristolochic acid-I in the medicinal plant has been developed in the presence of potential interferences of lead and cadmium by square wave voltametry (SWV). Among the phosphate buffers of pH values at 5.0, 6.1, 6.5 and 7.0, the phosphate buffers of pH 6.1 yielded the most accurate analysis of AA-I in the presence of Pb2+ and Cd2+; Pb2+ was precipitated as Pb(HPO4) and did not appear in the SW voltammogram, while Cd2+ appeared at -0.564 V which was well resolved from AA-I at -0.416 V. When the Ip of AA-I was plotted vs. concentrations between 1.67 x 10(-8) M and 1.67 x 10(-6) M in the presence of Pb2+ and Cd2+, a linear calibration curve was obtained with a slope of 6 x 10(8) nA/M and a correlation coefficient of 0.9999. The present method was applied to determine AA in the dried natural products of Aristolochia contorta Bunge; Total AA in the dried root and the ripe fructus of Aristolochia contorta Bunge were found as 25 +/- 1 microg/g and 85 +/- 3 microg/g, respectively.

Glassy Carbon Electrode Modified via Molybdenum Disulfide Decorated Multiwalled Carbon Nanotubes for Sensitive Voltammetric Detection of Aristolochic Acids

“…In order to investigate the application for real samples, the MoS 2 @MWCNTs/GCE was performed to determine AAs in chinese herbal Asarum sieboldii via the standard addition method . To make the analytical sample, 5 g of dried root of Asarum sieboldii was extracted three times with 300 mL ethanol by ultrasonic methods, followed by filtration and vacuum drying at 80 °C.…”

“…Electrochemical technology exhibits the advantages of simple instruments, low test cost and time consumption, high sensitivity, linear range, and easy monitoring . However, there are few electrochemical methods that analyze AA‐I and AA‐II . The electrochemical quantification of AA‐I and AA‐II is conducted via cyclic voltammetry (CV) on conventional bulk electrodes with a low detection limit and narrow linear range .…”

“…Additionally, Kim et al. developed a square wave voltammetry (SWV) to determine AA‐I in a medicinal plant with the existence of lead and cadmium . However, the sensitivity and selectivity of the electrochemical methods should be improved for detecting AAs.…”

MoS2 nanosheets grown on bowl-shaped hollow carbon spheres as an efficient electrochemical sensor for ultrasensitive determination of nephrotoxic aristolochic acids in Chinese traditional herbs

“…Unlike the methods aforementioned, electrochemical detection is a fast, sensitive, and accurate approach for the quantitative analysis of AA. Commonly used assays for detecting small natural drug molecules, such as AA, include square-wave voltammetry (SWV), 13 and differential pulse voltammetry (DPV). 14,15 Studies on the use of electrochemical analyses for AA detection are scarce.…”

Gold nanoparticle-enhanced luminol/ferricyanide chemiluminescence system for aristolochic acid-I detection in medicinal plants and slimming products

“…Furthermore, the literature survey reported a spectroscopic technique based on fluorescence analysis for the detection of AA-I derived DNA adducts in renal tissues (13). Finally, an electrochemical detection method based on square wave voltammetry was introduced to detect AA-I in Chinese medicinal plants with a limit of detection of 1.6 × 10 −8 mol L −1 (14).…”