Gold nanoparticle-enhanced luminol/ferricyanide chemiluminescence system for aristolochic acid-I detection in medicinal plants and slimming products

Oraby, Hesham F.; Alarfaj, Nawal A.; El‐Tohamy, Maha F.

doi:10.1080/17518253.2017.1330904

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…By comparison, a particle size in the range of 10–100 nm augments the CL reaction because of the catalytic enrichment and oxidation state changes involved in the electron transfer process. Under the condition of this study, the significant sharp CL signal obtained using the biogenic CeO 2 NPs suggests the active surface facilitation of oxidating luminol and the formation of superoxide intermediate radicals that enriched the CL signal [ 36 ]. Thus, the ultrasensitivity of the developed scheme supported the applicability of its usage in assessing and detecting different phenolic compounds in biological samples.…”

Section: Resultsmentioning

confidence: 99%

Maize Silk Biogenic Nanoceria (CeO2NPs) Enhanced Sequential Injection-Chemiluminescence Detection of Ferulic, Sinapic and p-Coumaric in Yellow Maize Kernels

Oraby

2022

Plants

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The current study demonstrated the capability of using maize silk as a green, simple, clean, safe, and cost-effective platform for the biosynthesis of cerium oxide (CeO2NPs). Several spectroscopic and microscopic analyses were employed to characterize the resulted biogenic nanoceria. When the concentration of the CeO2NPs was elevated from 25 to 100 ug mL−1, the CeO2NPs exhibited strong scavenging potential ranging from 60.21 to 75.11% and 56 to 77% for 1,1-diphenyl-2- picrylhydrazyl (DPPH•) and 2-2′-azino-bis(3-ethyl benzothiazoline-6-sulphonic acid) (ABTS) tests, respectively. The quantitative determination of ferulic, sinapic, and p-coumaric acids was carried out using an eco-friendly, cost-effective, and optimized ultrasensitive nanoceria enhanced sequential injection-chemiluminescence (SIA-CL) system. The highest amount was presented by the ferulic acid (1636 ± 2.61 ug/gdw), followed by p-coumaric acid (206 ± 1.12 ug/gdw) and sinapic acid (123 ± 2.15 ug/gdw). The intrinsic capabilities of the biogenic CeO2NPs in enhancing the developed system reveal its potential role in detecting phenolic compounds with great sensitivity.

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Section: Resultsmentioning

confidence: 99%

Maize Silk Biogenic Nanoceria (CeO2NPs) Enhanced Sequential Injection-Chemiluminescence Detection of Ferulic, Sinapic and p-Coumaric in Yellow Maize Kernels

Oraby

2022

Plants

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“…[1,2], a kind of Chinese herb. Moreover, these herbs can be used as raw materials of some drug homologous and healthy foods, and even dietary supplements [3][4][5]. However, it has been reported that AA showed toxicity to humans owing to carcinogenesis [2,[6][7][8], nephrotoxicity [9][10][11], and mutagenicity [9,12].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Anti-Aristolochic Acid I Monoclonal Antibody and Development of Chemiluminescent Immunoassay and Carbon Dot-Based Fluoroimmunoassay for Sensitive Detection of Aristolochic Acid I

Chen

Zhang

et al. 2021

Foods

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Aristolochic acid (AA) toxicity has been shown in humans regarding carcinogenesis, nephrotoxicity, and mutagenicity. Monitoring the AA content in drug homologous and healthy foods is necessary for the health of humans. In this study, a monoclonal antibody (mAb) with high sensitivity for aristolochic acid I (AA-I) was prepared. Based on the obtained mAb, a chemiluminescent immunoassay (CLEIA) against AA-I was developed, which showed the 50% decrease in the RLUmax (IC50) value of 1.8 ng/mL and the limit of detection (LOD) of 0.4 ng/mL. Carbon dots with red emission at 620 nm, namely rCDs, were synthesized and employed in conventional indirect competitive enzyme-linked immunosorbent assay (icELISA) to improve the assay sensitivity of a fluoroimmunoassay (FIA). Oxidized 3,3′′,5,5′′-tetramethylbenzidine dihydrochloride (oxTMB) can quench the emission of the rCDs through the inner-filter effect; therefore, the fluorescence intensity of rCDs can be regulated by the concentration of mAb. As a result, the assay sensitivity of FIA was improved by five-fold compared to CLEIA. A good relationship between the results of the proposed assays and the standard ultra-high performance liquid chromatography-triple quadrupole mass spectrometer (UPLC-QQQ-MS/MS) of real samples indicated good accuracy and practicability of CLEIA and FIA.

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“…A few typical methods are reported to detect AA‐I and AA‐II in aristolochia and related complex Chinese patent medicines such as thin chromatography , high‐performance liquid chromatography (HPLC) , and capillary electrophoresis (CE) . The HPLC methods for AAs detection are mainly based on different types of detectors such as a diode‐array detector , ultraviolet spectrum (UV) , mass spectrum (MS) , and fluorescence(FLD) detector due to the complex composition in target objects. Wang.…”

Section: Introductionmentioning

confidence: 99%

Glassy Carbon Electrode Modified via Molybdenum Disulfide Decorated Multiwalled Carbon Nanotubes for Sensitive Voltammetric Detection of Aristolochic Acids

Wang

Mamat

et al. 2019

Electroanalysis

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In this study, a molybdenum disulfide/multiwalled carbon nanotubes (MoS2@MWCNTs) nanocomposite was synthesized by employing a simple hydrothermal method. The flower‐like structure of the MoS2@MWCNTs was characterized via scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the load of crystalline MoS2 was verified via X‐ray diffraction (XRD) and energy‐dispersive spectroscopy (EDS). The as‐prepared MoS2@MWCNTs nanocomposite was used to modify glassy carbon electrode (GCE) as an electrochemical sensor for detecting aristolochic acids (AAs). With the optimized parameters, the proposed electrochemical sensor exhibited good sensitivity and a broad linear concentration range for detecting AAs from 0.2 to 10 μmol/L and 10 to 100 μmol/L, with the sensitivity of −3.10 μA/(μmol/L) and −0.91 μA/(μmol/L), respectively. The detection limit was also calculated as 0.06 μmol/L (S/N=3) based on the low background signal. Furthermore, the modified electrochemical sensor exhibited good selectivity, repeatability, reproducibility, and stability, thus showing potential application for detecting AA in chinese herbs with good mean recovery and accuracy. In other words, the MoS2@MWCNTs/GCE can be used as an excellent platform to detect AAs.

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Gold nanoparticle-enhanced luminol/ferricyanide chemiluminescence system for aristolochic acid-I detection in medicinal plants and slimming products

Cited by 16 publications

References 27 publications

Maize Silk Biogenic Nanoceria (CeO2NPs) Enhanced Sequential Injection-Chemiluminescence Detection of Ferulic, Sinapic and p-Coumaric in Yellow Maize Kernels

Maize Silk Biogenic Nanoceria (CeO2NPs) Enhanced Sequential Injection-Chemiluminescence Detection of Ferulic, Sinapic and p-Coumaric in Yellow Maize Kernels

Preparation of Anti-Aristolochic Acid I Monoclonal Antibody and Development of Chemiluminescent Immunoassay and Carbon Dot-Based Fluoroimmunoassay for Sensitive Detection of Aristolochic Acid I

Glassy Carbon Electrode Modified via Molybdenum Disulfide Decorated Multiwalled Carbon Nanotubes for Sensitive Voltammetric Detection of Aristolochic Acids

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