Electrochemical Aspects of Mass Spectrometry: Atmospheric Pressure Ionization and Ambient Ionization for Bioanalysis

Yuill, Elizabeth M.; Baker, Lane A.

doi:10.1002/celc.201600751

Cited by 13 publications

(10 citation statements)

References 211 publications

(421 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[48][49][50] The combination of a microfluidic chip and MS (Chip-MS) has been demonstrated for rapid detection and the analysis of single-cell metabolites. 34,36,[51][52][53][54][55][56][57] We have developed multi-functional probes with submicrometer dimensions for single-cell operation including electric cell lysis, mRNA quantification, and electrochemical monitoring of reporter gene expression. For this purpose, the glass pipette probe was coated with Pt/Ti by sputtering deposition equipment, and subsequently insulated with parylene C (Fig.…”

Section: •1 Multi-functional Probesmentioning

confidence: 99%

Electrochemical Biosensing System for Single Cells, Cellular Aggregates and Microenvironments

Shiku

2018

ANAL. SCI.

View full text Add to dashboard Cite

Applications of electrochemical biosensing for surveying intact cells and tissues have been focus of attention. Two experimental approaches have been used when performing amperometric measurements on biological cells, the stylustype microelectrode probes and the electrode-integrated microdevices based on lithographic technologies. For the probe scanning approach, various types of microsensors were developed to monitor localized physical or chemical natures at a variety of surfaces in situ under wet conditions. Scanning electrochemical microscopy (SECM) has been applied for monitoring local oxygen, enzyme activity, and collection of transcripts. For the non-scanning type of approach, electrode array devices allow very rapid response, parallel monitoring, and multi-analyte assay. Sveral topics of on-chip-culture system were introduced especially concerning on gene expression monitoring by reporter system and reconstruction of in vivo-like nature by controlling microenvironments. Electrochemical reporter assay has been demonstrated to monitor the gene expression process of the gene-modified cultured cells. Long-term monitoring of cellular function of spheroids and three dimensionally-cultured cells were carried out by controlling microenvironments on the cellular chip.

show abstract

Section: •1 Multi-functional Probesmentioning

confidence: 99%

Electrochemical Biosensing System for Single Cells, Cellular Aggregates and Microenvironments

Shiku

2018

ANAL. SCI.

View full text Add to dashboard Cite

show abstract

“…Electrochemical reactions can be used to oxidize or reduce analytes so as to improve the ionization of analytes for mass spectrometric analysis. [13] The development of EC-MS coupling is synchronized with the advent of ion sources of mass spectrometers which often serve as a part of the interface between an EC cell and a mass spectrometer. The work regarding the coupling of EC and MS originated in the early 1970s, when Brukkenstein and Gadde [14] used a teflon membrane porous platinum electrode so that gaseous products of NO and N 2 O generated at different potentials could permeate the membrane for the following ionization by electron impact.…”

Section: Introductionmentioning

confidence: 99%

“…In this hyphenation, MS has often been used due to its high sensitivity and specificity for determination of electrochemical reactions, providing structural information unavailable from EC methods. Electrochemical reactions can be used to oxidize or reduce analytes so as to improve the ionization of analytes for mass spectrometric analysis [13] …”

Section: Introductionmentioning

confidence: 99%

Recent Advances of In‐Source Electrochemical Mass Spectrometry

et al. 2021

View full text Add to dashboard Cite

Hyphenation of electrochemistry (EC) and mass spectrometry has become a powerful tool to study redox processes. Approaches that can achieve this hyphenation include integrating chromatography/electrophoresis between electroinduced redox reactions and detection of products, coupling an EC flow cell to a mass spectrometer, and performing electrochemical reactions inside the ion source of a mass spectrometer. The first two approaches have been well reviewed elsewhere. This Minireview highlights the inherent electrochemical properties of many mass spectrometry ion sources and their roles in the coupling of electrochemistry and mass spectrometric analysis. Development of modified ion sources that allow the compatibility of electrochemistry with ionization processes is also surveyed. Applications of different in-source electrochemical devices are provided including intermediate capturing, bioanalytical studies, nanoparticle formation, electrosynthesis, and electrode imaging.

show abstract

“…In addition, by scanning the sampling area on the sample, the distribution of chemical components can be imaged. to comprehensive reviews of atmospheric pressure sampling ionization, [31][32][33] chemical measurements 34) , metabolite measurements 35) and medical measurements 36,37) .…”

Section: Introductionmentioning

confidence: 99%

Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication)

Otsuka

2021

Mass Spectrometry

View full text Add to dashboard Cite

A combination of direct liquid extraction using a small volume of solvent and electrospray ionization allows the rapid measurement of complex chemical components in biological samples and visualization of their distribution in tissue sections. This review describes the development of such techniques and their application to biological research since the first reports in the early 2000s. An overview of electrospray ionization, ion suppression in samples, and the acceleration of specific chemical reactions in charged droplets is also presented. Potential future applications for visualizing multimolecular environments in biological systems are discussed.

show abstract

Electrochemical Aspects of Mass Spectrometry: Atmospheric Pressure Ionization and Ambient Ionization for Bioanalysis

Cited by 13 publications

References 211 publications

Electrochemical Biosensing System for Single Cells, Cellular Aggregates and Microenvironments

Electrochemical Biosensing System for Single Cells, Cellular Aggregates and Microenvironments

Recent Advances of In‐Source Electrochemical Mass Spectrometry

Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication)

Contact Info

Product

Resources

About